{"id":"https://openalex.org/W4362568487","doi":"https://doi.org/10.1158/2159-8290.22536202.v1","title":"Supplementary Figures and Legends from Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation","display_name":"Supplementary Figures and Legends from Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362568487","doi":"https://doi.org/10.1158/2159-8290.22536202.v1"},"language":"en","primary_location":{"id":"doi:10.1158/2159-8290.22536202.v1","doi":"https://doi.org/10.1158/2159-8290.22536202.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.22536202.v1","pdf_url":"https://aacr.figshare.com/ndownloader/files/39999496","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/ndownloader/files/39999496","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101882060","display_name":"Zhimin Gu","orcid":"https://orcid.org/0000-0002-4772-0158","observed_orcids":["https://orcid.org/0000-0002-4772-0158"]},"institutions":[{"id":"https://openalex.org/I1297463080","display_name":"Children's Medical Center","ror":"https://ror.org/02ndk3y82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1297463080"]},{"id":"https://openalex.org/I4390039370","display_name":"Harold C. Simmons Comprehensive Cancer Center","ror":"https://ror.org/03cbz4r60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhimin Gu","raw_affiliation_strings":["Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I1297463080","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115604803","display_name":"Yuxuan Liu","orcid":"https://orcid.org/0009-0008-6732-7717","observed_orcids":["https://orcid.org/0009-0008-6732-7717"]},"institutions":[{"id":"https://openalex.org/I1297463080","display_name":"Children's Medical Center","ror":"https://ror.org/02ndk3y82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1297463080"]},{"id":"https://openalex.org/I4390039370","display_name":"Harold C. Simmons Comprehensive Cancer Center","ror":"https://ror.org/03cbz4r60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuxuan Liu","raw_affiliation_strings":["Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I1297463080","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100531728","display_name":"Feng Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1297463080","display_name":"Children's Medical Center","ror":"https://ror.org/02ndk3y82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1297463080"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Feng Cai","raw_affiliation_strings":["Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I1297463080","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035274487","display_name":"McKenzie Patrick","orcid":"https://orcid.org/0000-0001-5891-1649","observed_orcids":["https://orcid.org/0000-0001-5891-1649"]},"institutions":[{"id":"https://openalex.org/I1297463080","display_name":"Children's Medical Center","ror":"https://ror.org/02ndk3y82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1297463080"]},{"id":"https://openalex.org/I4390039370","display_name":"Harold C. Simmons Comprehensive Cancer Center","ror":"https://ror.org/03cbz4r60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"McKenzie Patrick","raw_affiliation_strings":["Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I1297463080","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071937290","display_name":"Jakub Zmajkovic","orcid":"https://orcid.org/0000-0001-7061-6538","observed_orcids":["https://orcid.org/0000-0001-7061-6538"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jakub Zmajkovic","raw_affiliation_strings":["Department of Biomedicine, University Hospital Basel, CH -4031 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, University Hospital Basel, CH -4031 Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110514919","display_name":"Hui Cao","orcid":"https://orcid.org/0009-0004-2594-1015","observed_orcids":["https://orcid.org/0009-0004-2594-1015"]},"institutions":[{"id":"https://openalex.org/I1297463080","display_name":"Children's Medical Center","ror":"https://ror.org/02ndk3y82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1297463080"]},{"id":"https://openalex.org/I4390039370","display_name":"Harold C. Simmons Comprehensive Cancer Center","ror":"https://ror.org/03cbz4r60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui Cao","raw_affiliation_strings":["Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I1297463080","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063984108","display_name":"Yuannyu Zhang","orcid":"https://orcid.org/0000-0002-7016-7557","observed_orcids":["https://orcid.org/0000-0002-7016-7557"]},"institutions":[{"id":"https://openalex.org/I1297463080","display_name":"Children's Medical Center","ror":"https://ror.org/02ndk3y82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1297463080"]},{"id":"https://openalex.org/I4390039370","display_name":"Harold C. Simmons Comprehensive Cancer Center","ror":"https://ror.org/03cbz4r60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuannyu Zhang","raw_affiliation_strings":["Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I1297463080","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048453026","display_name":"Alpaslan Tasdogan","orcid":"https://orcid.org/0000-0003-2543-852X","observed_orcids":["https://orcid.org/0000-0003-2543-852X"]},"institutions":[{"id":"https://openalex.org/I1297463080","display_name":"Children's Medical Center","ror":"https://ror.org/02ndk3y82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1297463080"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alpaslan Tasdogan","raw_affiliation_strings":["Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I1297463080","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079900226","display_name":"Mingyi Chen","orcid":"https://orcid.org/0000-0001-6754-0480","observed_orcids":["https://orcid.org/0000-0001-6754-0480"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mingyi Chen","raw_affiliation_strings":["Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020716844","display_name":"Le Qi","orcid":"https://orcid.org/0000-0003-4832-2271","observed_orcids":["https://orcid.org/0000-0003-4832-2271"]},"institutions":[{"id":"https://openalex.org/I1297463080","display_name":"Children's Medical Center","ror":"https://ror.org/02ndk3y82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1297463080"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Le Qi","raw_affiliation_strings":["Children's Medical Center Research Institute , University of Texas Southwestern Medical Center , Dallas , TX 75390 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Medical Center Research Institute , University of Texas Southwestern Medical Center , Dallas , TX 75390 , USA","institution_ids":["https://openalex.org/I1297463080","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100352243","display_name":"Xin Liu","orcid":"https://orcid.org/0000-0002-5646-423X","observed_orcids":["https://orcid.org/0000-0002-5646-423X","https://orcid.org/0000-0003-0847-182X","https://orcid.org/0000-0003-3256-2940"]},"institutions":[{"id":"https://openalex.org/I1297463080","display_name":"Children's Medical Center","ror":"https://ror.org/02ndk3y82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1297463080"]},{"id":"https://openalex.org/I4390039370","display_name":"Harold C. Simmons Comprehensive Cancer Center","ror":"https://ror.org/03cbz4r60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin Liu","raw_affiliation_strings":["Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I1297463080","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070011755","display_name":"Kailong Li","orcid":"https://orcid.org/0000-0002-3311-5782","observed_orcids":["https://orcid.org/0000-0002-3311-5782","https://orcid.org/0009-0007-8891-9167"]},"institutions":[{"id":"https://openalex.org/I1297463080","display_name":"Children's Medical Center","ror":"https://ror.org/02ndk3y82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1297463080"]},{"id":"https://openalex.org/I4390039370","display_name":"Harold C. Simmons Comprehensive Cancer Center","ror":"https://ror.org/03cbz4r60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kailong Li","raw_affiliation_strings":["Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","Department of Pediatrics , Harold C. Simmons Comprehensive Cancer Center , and Hamon Center for Regenerative Science and Medicine , University of Texas Southwestern Medical Center , Dallas , TX 75390 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I1297463080","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Pediatrics , Harold C. Simmons Comprehensive Cancer Center , and Hamon Center for Regenerative Science and Medicine , University of Texas Southwestern Medical Center , Dallas , TX 75390 , USA","institution_ids":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013639146","display_name":"Junhua Lyu","orcid":"https://orcid.org/0000-0001-9617-0343","observed_orcids":["https://orcid.org/0000-0001-9617-0343"]},"institutions":[{"id":"https://openalex.org/I1297463080","display_name":"Children's Medical Center","ror":"https://ror.org/02ndk3y82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1297463080"]},{"id":"https://openalex.org/I4390039370","display_name":"Harold C. Simmons Comprehensive Cancer Center","ror":"https://ror.org/03cbz4r60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junhua Lyu","raw_affiliation_strings":["Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I1297463080","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048314789","display_name":"Kathryn E. Dickerson","orcid":"https://orcid.org/0000-0003-1220-2243","observed_orcids":["https://orcid.org/0000-0003-1220-2243"]},"institutions":[{"id":"https://openalex.org/I1297463080","display_name":"Children's Medical Center","ror":"https://ror.org/02ndk3y82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1297463080"]},{"id":"https://openalex.org/I4390039370","display_name":"Harold C. Simmons Comprehensive Cancer Center","ror":"https://ror.org/03cbz4r60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn E. Dickerson","raw_affiliation_strings":["Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"],"raw_orcid":"https://orcid.org/0000-0003-1220-2243","affiliations":[{"raw_affiliation_string":"Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I1297463080","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012895760","display_name":"Weina Chen","orcid":"https://orcid.org/0000-0001-5638-4371","observed_orcids":["https://orcid.org/0000-0001-5638-4371"]},"institutions":[{"id":"https://openalex.org/I1297463080","display_name":"Children's Medical Center","ror":"https://ror.org/02ndk3y82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1297463080"]},{"id":"https://openalex.org/I4390039370","display_name":"Harold C. Simmons Comprehensive Cancer Center","ror":"https://ror.org/03cbz4r60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weina Chen","raw_affiliation_strings":["Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I1297463080","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046311693","display_name":"Min Ni","orcid":"https://orcid.org/0000-0001-7180-3319","observed_orcids":["https://orcid.org/0000-0001-7180-3319"]},"institutions":[{"id":"https://openalex.org/I1297463080","display_name":"Children's Medical Center","ror":"https://ror.org/02ndk3y82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1297463080"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Ni","raw_affiliation_strings":["Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I1297463080","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001806074","display_name":"Matthew E. Merritt","orcid":"https://orcid.org/0000-0003-4617-9651","observed_orcids":["https://orcid.org/0000-0003-4617-9651"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew E. Merritt","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida"],"raw_orcid":"https://orcid.org/0000-0003-4617-9651","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079548260","display_name":"Sean J. Morrison","orcid":"https://orcid.org/0000-0003-1587-8329","observed_orcids":["https://orcid.org/0000-0003-1587-8329"]},"institutions":[{"id":"https://openalex.org/I1297463080","display_name":"Children's Medical Center","ror":"https://ror.org/02ndk3y82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1297463080"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean J. Morrison","raw_affiliation_strings":["Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I1297463080","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050358937","display_name":"Radek C. Skoda","orcid":"https://orcid.org/0000-0002-3626-9496","observed_orcids":["https://orcid.org/0000-0002-3626-9496"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Radek C. Skoda","raw_affiliation_strings":["Department of Biomedicine, University Hospital Basel, CH -4031 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, University Hospital Basel, CH -4031 Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013924501","display_name":"Ralph J. DeBerardinis","orcid":"https://orcid.org/0000-0002-2705-7432","observed_orcids":["https://orcid.org/0000-0002-2705-7432"]},"institutions":[{"id":"https://openalex.org/I1297463080","display_name":"Children's Medical Center","ror":"https://ror.org/02ndk3y82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1297463080"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph J. DeBerardinis","raw_affiliation_strings":["Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I1297463080","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088119941","display_name":"Jian Xu","orcid":"https://orcid.org/0000-0003-1988-7337","observed_orcids":["https://orcid.org/0000-0003-1988-7337"]},"institutions":[{"id":"https://openalex.org/I1297463080","display_name":"Children's Medical Center","ror":"https://ror.org/02ndk3y82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1297463080"]},{"id":"https://openalex.org/I4390039370","display_name":"Harold C. Simmons Comprehensive Cancer Center","ror":"https://ror.org/03cbz4r60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jian Xu","raw_affiliation_strings":["Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"],"raw_orcid":"https://orcid.org/0000-0003-1988-7337","affiliations":[{"raw_affiliation_string":"Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I1297463080","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5088119941"],"corresponding_institution_ids":["https://openalex.org/I1297463080","https://openalex.org/I4390039370","https://openalex.org/I867280407"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.36039999127388,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.36039999127388,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.1671999990940094,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.14550000429153442,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ezh2","display_name":"EZH2","score":0.9890000224113464},{"id":"https://openalex.org/keywords/branched-chain-amino-acid-metabolism","display_name":"branched-chain amino acid metabolism","score":0.9390000104904175},{"id":"https://openalex.org/keywords/leukemic-transformation","display_name":"leukemic transformation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/epigenetic-reprogramming","display_name":"epigenetic reprogramming","score":0.7129999995231628},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.41600000858306885}],"concepts":[{"id":"https://openalex.org/C204241405","wikidata":"https://www.wikidata.org/wiki/Q461499","display_name":"Transformation (genetics)","level":3,"score":0.7172185182571411},{"id":"https://openalex.org/C50171091","wikidata":"https://www.wikidata.org/wiki/Q17917770","display_name":"EZH2","level":4,"score":0.46634310483932495},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3579155206680298},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21343371272087097},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.10064774751663208},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05352070927619934}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/2159-8290.22536202.v1","doi":"https://doi.org/10.1158/2159-8290.22536202.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.22536202.v1","pdf_url":"https://aacr.figshare.com/ndownloader/files/39999496","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22536202","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figures_and_Legends_from_Loss_of_EZH2_Reprograms_BCAA_Metabolism_to_Drive_Leukemic_Transformation/22536202","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/2159-8290.22536202.v1","doi":"https://doi.org/10.1158/2159-8290.22536202.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.22536202.v1","pdf_url":"https://aacr.figshare.com/ndownloader/files/39999496","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4362568487.pdf","grobid_xml":"https://content.openalex.org/works/W4362568487.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4362567155","https://openalex.org/W4362567393","https://openalex.org/W4362568220","https://openalex.org/W4362566997","https://openalex.org/W4362567602","https://openalex.org/W4362568319","https://openalex.org/W2950184715","https://openalex.org/W2888639563","https://openalex.org/W4243408293","https://openalex.org/W2972198904"],"abstract_inverted_index":{"Supplementary":[0],"Figures":[1],"and":[2],"Legends":[3],"combined":[4],"file":[5],"contains":[6],"14":[7],"supplementary":[8],"figures":[9]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-04-06T00:00:00"}