{"id":"https://openalex.org/W4362568059","doi":"https://doi.org/10.1158/1541-7786.c.6545058.v1","title":"Data from Stromal CAVIN1 Controls Prostate Cancer Microenvironment and Metastasis by Modulating Lipid Distribution and Inflammatory Signaling","display_name":"Data from Stromal CAVIN1 Controls Prostate Cancer Microenvironment and Metastasis by Modulating Lipid Distribution and Inflammatory Signaling","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362568059","doi":"https://doi.org/10.1158/1541-7786.c.6545058.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1541-7786.c.6545058.v1","doi":"https://doi.org/10.1158/1541-7786.c.6545058.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.6545058.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1541-7786.c.6545058.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067987111","display_name":"Jin\u2010Yih Low","orcid":"https://orcid.org/0000-0002-6058-7398","observed_orcids":["https://orcid.org/0000-0002-6058-7398"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jin-Yih Low","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033192114","display_name":"William Nathaniel Brennen","orcid":"https://orcid.org/0000-0001-9807-7433","observed_orcids":["https://orcid.org/0000-0001-9807-7433"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. Nathaniel Brennen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9807-7433","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028865365","display_name":"Alan Keith Meeker","orcid":"https://orcid.org/0000-0003-4601-6481","observed_orcids":["https://orcid.org/0000-0003-4601-6481"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alan K. Meeker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068795367","display_name":"Elina Ikonen","orcid":"https://orcid.org/0000-0001-8382-1135","observed_orcids":["https://orcid.org/0000-0001-8382-1135"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elina Ikonen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075645665","display_name":"Brian Wesley Simons","orcid":"https://orcid.org/0000-0003-0644-211X","observed_orcids":["https://orcid.org/0000-0003-0644-211X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian W. Simons","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5028508240","display_name":"Marikki Laiho","orcid":"https://orcid.org/0000-0002-5625-6430","observed_orcids":["https://orcid.org/0000-0002-5625-6430"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marikki Laiho","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.08950000256299973,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cavin-1","display_name":"cavin-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.765999972820282},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8659999966621399},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8389999866485596},{"id":"https://openalex.org/keywords/caveolae","display_name":"caveolae","score":0.7730000019073486},{"id":"https://openalex.org/keywords/lipid-uptake","display_name":"lipid uptake","score":0.6200000047683716},{"id":"https://openalex.org/keywords/lipid-droplets","display_name":"lipid droplets","score":0.8610000014305115},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.7379999756813049},{"id":"https://openalex.org/keywords/m2-macrophages","display_name":"M2 macrophages","score":0.8109999895095825},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cancer-associated-fibroblasts","display_name":"cancer-associated fibroblasts","score":0.8119999766349792},{"id":"https://openalex.org/keywords/tumor-cell-migration-and-invasion","display_name":"tumor cell migration and invasion","score":0.6710000038146973},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.8513585329055786},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.7125290036201477},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.7107623815536499},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7030352354049683},{"id":"https://openalex.org/C49866891","wikidata":"https://www.wikidata.org/wiki/Q1051872","display_name":"Caveolae","level":3,"score":0.6726742386817932},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6204096078872681},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.571052610874176},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5079663395881653},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.46740442514419556},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45300284028053284},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.423836886882782},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4222910404205322},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35456445813179016},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33948713541030884},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3199475109577179},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30879998207092285},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23334038257598877},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.23327693343162537},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1991192102432251},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1541-7786.c.6545058.v1","doi":"https://doi.org/10.1158/1541-7786.c.6545058.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.6545058.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1541-7786.c.6545058.v1","doi":"https://doi.org/10.1158/1541-7786.c.6545058.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.6545058.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3030956731","https://openalex.org/W1521827187","https://openalex.org/W1988671179","https://openalex.org/W2317337810","https://openalex.org/W2052307676","https://openalex.org/W1580852618","https://openalex.org/W2044446034","https://openalex.org/W3080896648","https://openalex.org/W29340505","https://openalex.org/W2153006061"],"abstract_inverted_index":{"Abstract":[0],"Lipid":[1],"uptake":[2,116],"occurs":[3],"through":[4],"caveolae,":[5],"plasma":[6],"membrane":[7],"invaginations":[8],"formed":[9],"by":[10,35,144,165],"caveolins":[11],"(CAV)":[12],"and":[13,22,27,41,44,52,79,98,110,117,126,148,171],"caveolae-associated":[14],"protein":[15],"1":[16],"(CAVIN1).":[17],"Genetic":[18],"alterations":[19],"of":[20,86],"CAV1N1":[21],"CAV1":[23],"modify":[24],"lipid":[25,72,95,115,146,169],"metabolism":[26,40],"underpin":[28],"lipodystrophy":[29],"syndromes.":[30],"Lipids":[31],"contribute":[32,139],"to":[33,38,62,128,140],"tumorigenesis":[34],"providing":[36],"fuel":[37],"cancer":[39,77,107,142,163],"supporting":[42],"growth":[43],"signaling.":[45],"Tumor":[46],"stroma":[47],"promotes":[48],"tumor":[49,152,167],"proliferation,":[50],"invasion,":[51],"metastasis,":[53],"but":[54],"how":[55],"stromal":[56,69,90,137,159],"lipids":[57],"influence":[58],"these":[59],"processes":[60],"remain":[61],"be":[63],"defined.":[64],"Here,":[65],"we":[66],"show":[67,83],"that":[68,84,136,158],"CAVIN1":[70,87,104,160],"regulates":[71],"abundance":[73],"in":[74,88,122,150],"the":[75,123,134,151],"prostate":[76,89,106,141,162],"microenvironment":[78],"suppresses":[80,161],"metastasis.":[81],"We":[82],"depletion":[85],"cells":[91,102,138],"markedly":[92],"reduces":[93],"their":[94],"droplet":[96],"accumulation":[97],"increases":[99],"inflammation.":[100],"Stromal":[101],"lacking":[103],"enhance":[105],"cell":[108],"migration":[109],"invasion.":[111],"Remarkably,":[112],"they":[113],"increase":[114],"M2":[118],"inflammatory":[119,172],"macrophage":[120],"infiltration":[121],"primary":[124],"tumors":[125],"metastasis":[127,164],"distant":[129],"sites.":[130],"Our":[131],"data":[132],"support":[133],"concept":[135],"aggressiveness":[143],"modulating":[145,166],"content":[147],"inflammation":[149],"microenvironment.":[153],"Implications:":[154],"This":[155],"study":[156],"showed":[157],"microenvironment,":[168],"content,":[170],"response.":[173]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-04-06T00:00:00"}
