{"id":"https://openalex.org/W4362567690","doi":"https://doi.org/10.1158/1535-7163.c.6539268.v1","title":"Data from Covalent Targeting of Fibroblast Growth Factor Receptor Inhibits Metastatic Breast Cancer","display_name":"Data from Covalent Targeting of Fibroblast Growth Factor Receptor Inhibits Metastatic Breast Cancer","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362567690","doi":"https://doi.org/10.1158/1535-7163.c.6539268.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.c.6539268.v1","doi":"https://doi.org/10.1158/1535-7163.c.6539268.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6539268.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1535-7163.c.6539268.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061255878","display_name":"Wells S. Brown","orcid":"https://orcid.org/0000-0002-6979-9143","observed_orcids":["https://orcid.org/0000-0002-6979-9143"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wells S. Brown","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100428609","display_name":"Li Tan","orcid":"https://orcid.org/0000-0002-1199-9046","observed_orcids":["https://orcid.org/0000-0002-1199-9046"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li Tan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Andrew Smith","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Smith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022352605","display_name":"Nathanael S. Gray","orcid":"https://orcid.org/0000-0001-5354-7403","observed_orcids":["https://orcid.org/0000-0001-5354-7403"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nathanael S. Gray","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5090843213","display_name":"Michael K. Wendt","orcid":"https://orcid.org/0000-0002-3665-7413","observed_orcids":["https://orcid.org/0000-0002-3665-7413"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael K. Wendt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fgfr1","display_name":"FGFR1","score":0.8169999718666077},{"id":"https://openalex.org/keywords/integrin-beta3","display_name":"CD61","score":0.8989999890327454},{"id":"https://openalex.org/keywords/focal-adhesion-kinase","display_name":"focal adhesion kinase","score":0.8690000176429749},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9829999804496765},{"id":"https://openalex.org/keywords/fgf2-signaling","display_name":"FGF2 signaling","score":0.8270000219345093},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.972000002861023},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.8769999742507935},{"id":"https://openalex.org/keywords/basal-like-breast-cancer","display_name":"basal-like breast cancer","score":0.8330000042915344},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.7229999899864197},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C82867764","wikidata":"https://www.wikidata.org/wiki/Q24780051","display_name":"Fibroblast growth factor receptor","level":4,"score":0.8178064823150635},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6855154037475586},{"id":"https://openalex.org/C49418065","wikidata":"https://www.wikidata.org/wiki/Q14914258","display_name":"Fibroblast growth factor receptor 1","level":4,"score":0.6431557536125183},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.5434485077857971},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5423113107681274},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.4895237684249878},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.4774787425994873},{"id":"https://openalex.org/C151166631","wikidata":"https://www.wikidata.org/wiki/Q904514","display_name":"Focal adhesion","level":3,"score":0.4567315876483917},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4507380723953247},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4419858157634735},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42479410767555237},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.37479227781295776},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3735896646976471},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.325926274061203},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09619060158729553},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.c.6539268.v1","doi":"https://doi.org/10.1158/1535-7163.c.6539268.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6539268.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.c.6539268.v1","doi":"https://doi.org/10.1158/1535-7163.c.6539268.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6539268.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2472922625","https://openalex.org/W2887076082","https://openalex.org/W2002889122","https://openalex.org/W2160457467","https://openalex.org/W4392684221","https://openalex.org/W1969083290","https://openalex.org/W4396587751","https://openalex.org/W7128585958","https://openalex.org/W2013237511","https://openalex.org/W2806574611"],"abstract_inverted_index":{"Abstract":[0],"Therapeutic":[1],"targeting":[2,32,154],"of":[3,13,31,50,86,98,105,116,139,143,149,155,162,187,193,242,247],"late-stage":[4],"breast":[5,100,150,196,248],"cancer":[6,101,197],"is":[7,57],"limited":[8],"by":[9,23],"an":[10,51,75],"inadequate":[11],"understanding":[12],"how":[14],"tumor":[15],"cell":[16],"signaling":[17,92,111],"evolves":[18],"during":[19],"metastatic":[20,61,99,175],"progression":[21],"and":[22,42,79,93,132,199,227],"the":[24,113,146,160,191,204,208,240,243],"currently":[25,180],"available":[26,181],"small":[27,168],"molecule":[28],"inhibitors":[29],"capable":[30,138],"these":[33,123,229],"processes.":[34],"Herein,":[35],"we":[36,126],"demonstrate":[37,127,211],"that":[38,56,128,212,228],"both":[39],"\u03b23":[40,71,106,130],"integrin":[41,72,107],"fibroblast":[43,66],"growth":[44,67,192],"factor":[45],"receptor-1":[46],"(FGFR1)":[47],"are":[48],"part":[49],"epithelial\u2013mesenchymal":[52],"transition":[53],"(EMT)":[54],"program":[55],"required":[58],"to":[59,65,82,108,222],"facilitate":[60],"outgrowth":[62,97,176],"in":[63,159,215],"response":[64],"factor-2":[68],"(FGF2).":[69],"Mechanistically,":[70],"physically":[73],"disrupts":[74],"interaction":[76],"between":[77],"FGFR1":[78,87,213],"E-cadherin,":[80],"leading":[81],"a":[83,135,156],"dramatic":[84],"redistribution":[85],"subcellular":[88],"localization,":[89],"enhanced":[90],"FGF2":[91],"increased":[94],"three-dimensional":[95],"(3D)":[96],"cells.":[102],"This":[103],"ability":[104],"drive":[109,223],"FGFR":[110,182],"requires":[112],"enzymatic":[114],"activity":[115],"focal":[117],"adhesion":[118],"kinase":[119],"(FAK).":[120],"Consistent":[121],"with":[122,145,164,179,217],"mechanistic":[124],"data,":[125],"FGFR,":[129],"integrin,":[131],"FAK":[133],"constitute":[134],"molecular":[136],"signature":[137],"predicting":[140],"decreased":[141],"survival":[142],"patients":[144],"basal-like":[147],"subtype":[148],"cancer.":[151,249],"Importantly,":[152],"covalent":[153],"conserved":[157],"cysteine":[158],"P-loop":[161],"FGFR1\u20134":[163],"our":[165,236],"newly":[166],"developed":[167],"molecule,":[169],"FIIN-4,":[170],"more":[171],"effectively":[172,233],"blocks":[173],"3D":[174],"as":[177],"compared":[178],"inhibitors.":[183],"In":[184],"vivo":[185],"application":[186],"FIIN-4":[188],"potently":[189],"inhibited":[190],"metastatic,":[194],"patient-derived":[195],"xenografts":[198],"murine-derived":[200],"metastases":[201],"growing":[202],"within":[203],"pulmonary":[205],"microenvironment.":[206],"Overall,":[207],"current":[209],"studies":[210],"works":[214],"concert":[216],"other":[218],"EMT":[219],"effector":[220],"molecules":[221],"aberrant":[224],"downstream":[225],"signaling,":[226],"events":[230],"can":[231],"be":[232],"targeted":[234],"using":[235],"novel":[237],"therapeutics":[238],"for":[239],"treatment":[241],"most":[244],"aggressive":[245],"forms":[246],"Mol":[250],"Cancer":[251],"Ther;":[252],"15(9);":[253],"2096\u2013106.":[254],"\u00a92016":[255],"AACR.":[256]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2023-04-06T00:00:00"}