{"id":"https://openalex.org/W4362555607","doi":"https://doi.org/10.1158/2159-8290.22541321.v1","title":"Supplementary Figure from Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer","display_name":"Supplementary Figure from Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer","publication_year":2023,"publication_date":"2023-04-04","ids":{"openalex":"https://openalex.org/W4362555607","doi":"https://doi.org/10.1158/2159-8290.22541321.v1"},"language":"en","primary_location":{"id":"doi:10.1158/2159-8290.22541321.v1","doi":"https://doi.org/10.1158/2159-8290.22541321.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2159-8290.22541321.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_from_Ontogeny_and_Vulnerabilities_of_Drug-Tolerant_Persisters_in_HER2_sup_sup_Breast_Cancer/22541321/1/files/40004693.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_from_Ontogeny_and_Vulnerabilities_of_Drug-Tolerant_Persisters_in_HER2_sup_sup_Breast_Cancer/22541321/1/files/40004693.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048892148","display_name":"Chewei Anderson Chang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chewei Anderson Chang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016696800","display_name":"Jayu Jen","orcid":"https://orcid.org/0000-0002-0926-9984","observed_orcids":["https://orcid.org/0000-0002-0926-9984"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jayu Jen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0926-9984","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081219089","display_name":"Shaowen Jiang","orcid":"https://orcid.org/0000-0002-8934-0161","observed_orcids":["https://orcid.org/0000-0002-8934-0161"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shaowen Jiang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055913635","display_name":"Azin Sayad","orcid":"https://orcid.org/0009-0005-1169-6319","observed_orcids":["https://orcid.org/0009-0005-1169-6319"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Azin Sayad","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011450761","display_name":"Arvind Singh Mer","orcid":"https://orcid.org/0000-0001-8510-7963","observed_orcids":["https://orcid.org/0000-0001-8510-7963"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arvind Singh Mer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8510-7963","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081128613","display_name":"Kevin R. Brown","orcid":"https://orcid.org/0000-0002-5514-2538","observed_orcids":["https://orcid.org/0000-0002-5514-2538"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin R. Brown","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5514-2538","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003875583","display_name":"Allison M.L. Nixon","orcid":"https://orcid.org/0000-0002-5540-4534","observed_orcids":["https://orcid.org/0000-0002-5540-4534"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Allison M.L. Nixon","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5540-4534","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074169117","display_name":"Avantika Dhabaria","orcid":"https://orcid.org/0000-0002-0799-3223","observed_orcids":["https://orcid.org/0000-0002-0799-3223"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Avantika Dhabaria","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028204025","display_name":"Kwan Ho Tang","orcid":"https://orcid.org/0000-0001-7729-5159","observed_orcids":["https://orcid.org/0000-0001-7729-5159"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kwan Ho Tang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7729-5159","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048492884","display_name":"David Venet","orcid":"https://orcid.org/0000-0001-9038-5271","observed_orcids":["https://orcid.org/0000-0001-9038-5271"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Venet","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9038-5271","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057269336","display_name":"Christos P. Sotiriou","orcid":"https://orcid.org/0000-0002-5745-9977","observed_orcids":["https://orcid.org/0000-0002-5745-9977"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christos Sotiriou","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5745-9977","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006842710","display_name":"Jiehui Deng","orcid":"https://orcid.org/0000-0001-7986-8643","observed_orcids":["https://orcid.org/0000-0001-7986-8643"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiehui Deng","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7986-8643","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019034689","display_name":"Kwok\u2010Kin Wong","orcid":"https://orcid.org/0000-0001-6323-235X","observed_orcids":["https://orcid.org/0000-0001-6323-235X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kwok-kin Wong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035762260","display_name":"Sylvia Adams","orcid":"https://orcid.org/0000-0003-4737-1952","observed_orcids":["https://orcid.org/0000-0003-4737-1952"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sylvia Adams","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011391777","display_name":"Peter Meyn","orcid":"https://orcid.org/0009-0001-3436-7682","observed_orcids":["https://orcid.org/0009-0001-3436-7682"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Meyn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025018584","display_name":"Adriana Heguy","orcid":"https://orcid.org/0000-0002-2836-6683","observed_orcids":["https://orcid.org/0000-0002-2836-6683"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adriana Heguy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083464518","display_name":"Jane A. Skok","orcid":"https://orcid.org/0000-0002-4145-1516","observed_orcids":["https://orcid.org/0000-0002-4145-1516"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jane A. Skok","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4145-1516","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051845185","display_name":"Aristotelis Tsirigos","orcid":"https://orcid.org/0000-0002-7512-8477","observed_orcids":["https://orcid.org/0000-0002-7512-8477"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aristotelis Tsirigos","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7512-8477","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046586712","display_name":"Beatrix M. Ueberheide","orcid":"https://orcid.org/0000-0003-2512-0204","observed_orcids":["https://orcid.org/0000-0003-2512-0204"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Beatrix Ueberheide","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086112491","display_name":"Jason Moffat","orcid":"https://orcid.org/0000-0002-5663-8586","observed_orcids":["https://orcid.org/0000-0002-5663-8586"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason Moffat","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5663-8586","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022267407","display_name":"Abhyudai Singh","orcid":"https://orcid.org/0000-0002-1451-2838","observed_orcids":["https://orcid.org/0000-0002-1451-2838"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abhyudai Singh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010487226","display_name":"Benjamin Haibe\u2010Kains","orcid":"https://orcid.org/0000-0002-7684-0079","observed_orcids":["https://orcid.org/0000-0002-7684-0079"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benjamin Haibe-Kains","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7684-0079","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086130553","display_name":"Alireza Khodadadi\u2010Jamayran","orcid":"https://orcid.org/0000-0003-2495-7504","observed_orcids":["https://orcid.org/0000-0003-2495-7504"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alireza Khodadadi-Jamayran","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2495-7504","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5061899406","display_name":"Benjamin G. Neel","orcid":"https://orcid.org/0000-0002-9589-585X","observed_orcids":["https://orcid.org/0000-0002-9589-585X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benjamin G. Neel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.5708000063896179,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.5708000063896179,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.3400999903678894,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-tolerant-persisters","display_name":"drug-tolerant persisters","score":0.9419999718666077},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.9779999852180481},{"id":"https://openalex.org/keywords/ontogeny","display_name":"ontogeny","score":0.6970000267028809},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7580000162124634},{"id":"https://openalex.org/keywords/cancer-cell-vulnerability","display_name":"cancer cell vulnerability","score":0.3659999966621399},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C37291498","wikidata":"https://www.wikidata.org/wiki/Q193603","display_name":"Ontogeny","level":2,"score":0.7685986757278442},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6787024140357971},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5314468741416931},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4287067949771881},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37411051988601685},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3542966842651367},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3177162706851959},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3167586326599121},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2698482275009155}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/2159-8290.22541321.v1","doi":"https://doi.org/10.1158/2159-8290.22541321.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2159-8290.22541321.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_from_Ontogeny_and_Vulnerabilities_of_Drug-Tolerant_Persisters_in_HER2_sup_sup_Breast_Cancer/22541321/1/files/40004693.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22541321","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_from_Ontogeny_and_Vulnerabilities_of_Drug-Tolerant_Persisters_in_HER2_sup_sup_Breast_Cancer/22541321","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/2159-8290.22541321.v1","doi":"https://doi.org/10.1158/2159-8290.22541321.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2159-8290.22541321.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_from_Ontogeny_and_Vulnerabilities_of_Drug-Tolerant_Persisters_in_HER2_sup_sup_Breast_Cancer/22541321/1/files/40004693.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4362555607.pdf","grobid_xml":"https://content.openalex.org/works/W4362555607.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4200132645","https://openalex.org/W4362546501","https://openalex.org/W7127042254","https://openalex.org/W7127118078","https://openalex.org/W4296295654","https://openalex.org/W7155558414","https://openalex.org/W4408462690","https://openalex.org/W7164991101","https://openalex.org/W7165009912","https://openalex.org/W4408471134"],"abstract_inverted_index":{"Supplementary":[0],"Figure":[1],"from":[2],"Ontogeny":[3],"and":[4],"Vulnerabilities":[5],"of":[6],"Drug-Tolerant":[7],"Persisters":[8],"in":[9],"HER2+":[10],"Breast":[11],"Cancer":[12]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-04-06T00:00:00"}