{"id":"https://openalex.org/W4362554464","doi":"https://doi.org/10.1158/2159-8290.22541682.v1","title":"Supplementary Figure 7 from A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability","display_name":"Supplementary Figure 7 from A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability","publication_year":2023,"publication_date":"2023-04-04","ids":{"openalex":"https://openalex.org/W4362554464","doi":"https://doi.org/10.1158/2159-8290.22541682.v1"},"language":"en","primary_location":{"id":"doi:10.1158/2159-8290.22541682.v1","doi":"https://doi.org/10.1158/2159-8290.22541682.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.22541682.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_7_from_A_Small_Molecule_Reacts_with_the_p53_Somatic_Mutant_Y220C_to_Rescue_Wild-type_Thermal_Stability/22541682/1/files/40005045.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_7_from_A_Small_Molecule_Reacts_with_the_p53_Somatic_Mutant_Y220C_to_Rescue_Wild-type_Thermal_Stability/22541682/1/files/40005045.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042019588","display_name":"Keelan Z. Guiley","orcid":"https://orcid.org/0000-0002-8149-4262","observed_orcids":["https://orcid.org/0000-0002-8149-4262"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keelan Z. Guiley","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8149-4262","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5079376363","display_name":"Kevan M. Shokat","orcid":"https://orcid.org/0000-0001-8590-7741","observed_orcids":["https://orcid.org/0000-0001-8590-7741"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevan M. Shokat","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8590-7741","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-molecules","display_name":"small molecules","score":0.5109999775886536},{"id":"https://openalex.org/keywords/thermal-stability","display_name":"thermal stability","score":0.722000002861023},{"id":"https://openalex.org/keywords/nutlin-3a","display_name":"Nutlin-3a","score":0.8939999938011169},{"id":"https://openalex.org/keywords/mdm2","display_name":"MDM2","score":0.7139999866485596},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9879999756813049},{"id":"https://openalex.org/keywords/p53-binding","display_name":"p53 binding","score":0.5419999957084656},{"id":"https://openalex.org/keywords/p53-targeted-therapy","display_name":"p53-targeted therapy","score":0.4880000054836273},{"id":"https://openalex.org/keywords/cancer-cell-viability","display_name":"tumor cell viability","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.6662031412124634},{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.6474822163581848},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6176518201828003},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6000059247016907},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.584039032459259},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4905092120170593},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4882078468799591},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4543038308620453},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.43014150857925415},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.42490458488464355},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3674194812774658},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35172998905181885},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2266697883605957},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22528108954429626}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/2159-8290.22541682.v1","doi":"https://doi.org/10.1158/2159-8290.22541682.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.22541682.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_7_from_A_Small_Molecule_Reacts_with_the_p53_Somatic_Mutant_Y220C_to_Rescue_Wild-type_Thermal_Stability/22541682/1/files/40005045.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22541682","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_7_from_A_Small_Molecule_Reacts_with_the_p53_Somatic_Mutant_Y220C_to_Rescue_Wild-type_Thermal_Stability/22541682","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/2159-8290.22541682.v1","doi":"https://doi.org/10.1158/2159-8290.22541682.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.22541682.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_7_from_A_Small_Molecule_Reacts_with_the_p53_Somatic_Mutant_Y220C_to_Rescue_Wild-type_Thermal_Stability/22541682/1/files/40005045.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4362554464.pdf","grobid_xml":"https://content.openalex.org/works/W4362554464.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4417194342","https://openalex.org/W4302009534","https://openalex.org/W4362546523","https://openalex.org/W1983374447","https://openalex.org/W2067026855","https://openalex.org/W4417194344","https://openalex.org/W4417194343","https://openalex.org/W4405039505","https://openalex.org/W4414403272","https://openalex.org/W7047533313"],"abstract_inverted_index":{"Supplementary":[0],"Figure":[1],"S7:":[2],"Extended":[3],"p53":[4,41,47,50,68],"Y220C":[5],"KG13":[6,25,62,76,87],"cellular":[7],"activity":[8],"(A)":[9],"Western":[10],"blot":[11],"for":[12,26,37,43,73,86,92],"isogenic":[13],"cell":[14],"panel":[15],"treated":[16,77],"with":[17],"10":[18,23],"\u03bcM":[19,24,75],"Nutlin-3a":[20,93],"constant":[21],"or":[22],"1":[27],"hr":[28],"at":[29,53],"28\u00b0C,":[30],"washed":[31],"out,":[32],"then":[33],"moved":[34],"to":[35,59],"37\u00b0C":[36],"8hr.":[38],"(B)":[39],"ChIP":[40,51],"enrichment":[42,52],"U2OS":[44],"cells":[45,66],"expressing":[46,67],"Y220C.":[48,69],"(C)":[49],"CDKN1A":[54],"and":[55,80],"MDM2":[56],"promoters":[57],"relative":[58],"IgG":[60],"following":[61],"treatment":[63],"in":[64],"H1299":[65],"(D)":[70],"RT-qPCR":[71],"results":[72],"25":[74],"NUGC-4,":[78],"NUGC-3,":[79],"BxPC-3\u00df":[81],"cells.":[82],"(E)":[83],"Viability":[84,90],"assay":[85,91],"treatment.":[88,94],"(F)":[89]},"counts_by_year":[],"updated_date":"2026-09-07T09:17:50.787605","created_date":"2023-04-06T00:00:00"}