{"id":"https://openalex.org/W4362546352","doi":"https://doi.org/10.1158/2159-8290.c.6549469.v1","title":"Data from Chemotherapy Induces Senescence-Like Resilient Cells Capable of Initiating AML Recurrence","display_name":"Data from Chemotherapy Induces Senescence-Like Resilient Cells Capable of Initiating AML Recurrence","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362546352","doi":"https://doi.org/10.1158/2159-8290.c.6549469.v1"},"language":"en","primary_location":{"id":"doi:10.1158/2159-8290.c.6549469.v1","doi":"https://doi.org/10.1158/2159-8290.c.6549469.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.c.6549469.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2159-8290.c.6549469.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059800716","display_name":"Cihangir Duy","orcid":"https://orcid.org/0000-0001-9150-9379","observed_orcids":["https://orcid.org/0000-0001-9150-9379"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cihangir Duy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100457509","display_name":"Meng Li","orcid":"https://orcid.org/0000-0002-8000-3003","observed_orcids":["https://orcid.org/0000-0002-8000-3003","https://orcid.org/0009-0005-4981-347X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meng Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030691616","display_name":"Matt R. Teater","orcid":"https://orcid.org/0000-0001-9415-1659","observed_orcids":["https://orcid.org/0000-0001-9415-1659"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matt Teater","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9415-1659","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000870253","display_name":"Cem Meydan","orcid":"https://orcid.org/0000-0002-0663-6216","observed_orcids":["https://orcid.org/0000-0002-0663-6216"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cem Meydan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0663-6216","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079337017","display_name":"Francine E. Garrett-Bakelman","orcid":"https://orcid.org/0000-0002-4771-628X","observed_orcids":["https://orcid.org/0000-0002-4771-628X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francine E. Garrett-Bakelman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4771-628X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073509401","display_name":"Tak C. Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tak C. Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080920057","display_name":"Christopher R. Chin","orcid":"https://orcid.org/0000-0002-2140-3197","observed_orcids":["https://orcid.org/0000-0002-2140-3197"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher R. Chin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2140-3197","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020704669","display_name":"Ceyda Durmaz","orcid":"https://orcid.org/0000-0002-7050-3653","observed_orcids":["https://orcid.org/0000-0002-7050-3653"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ceyda Durmaz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011196103","display_name":"Kimihito Cojin Kawabata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kimihito C. Kawabata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074250265","display_name":"Eugen Dhimolea","orcid":"https://orcid.org/0000-0002-8445-5509","observed_orcids":["https://orcid.org/0000-0002-8445-5509"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eugen Dhimolea","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012712111","display_name":"Constantine S. Mitsiades","orcid":"https://orcid.org/0000-0003-2321-8005","observed_orcids":["https://orcid.org/0000-0003-2321-8005"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Constantine S. Mitsiades","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089395073","display_name":"Hartmut D\u00f6hner","orcid":"https://orcid.org/0000-0003-2116-5536","observed_orcids":["https://orcid.org/0000-0003-2116-5536"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hartmut Doehner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040177912","display_name":"Richard J. D\u2019Andrea","orcid":"https://orcid.org/0000-0002-4915-4612","observed_orcids":["https://orcid.org/0000-0002-4915-4612"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard J. D'Andrea","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090207924","display_name":"Michael W. Becker","orcid":"https://orcid.org/0000-0001-9890-8815","observed_orcids":["https://orcid.org/0000-0001-9890-8815"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael W. Becker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079511754","display_name":"Elisabeth M. Paietta","orcid":"https://orcid.org/0000-0002-0561-5544","observed_orcids":["https://orcid.org/0000-0002-0561-5544"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elisabeth M. Paietta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085435765","display_name":"Christopher E. Mason","orcid":"https://orcid.org/0000-0002-1850-1642","observed_orcids":["https://orcid.org/0000-0002-1850-1642"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher E. Mason","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1850-1642","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032477226","display_name":"Martin P Carroll","orcid":"https://orcid.org/0000-0002-5622-3735","observed_orcids":["https://orcid.org/0000-0002-5622-3735"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin Carroll","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5019770989","display_name":"Ari M. Melnick","orcid":"https://orcid.org/0000-0002-8074-2287","observed_orcids":["https://orcid.org/0000-0002-8074-2287"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ari M. Melnick","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8074-2287","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.03720000013709068,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/relapsed-aml","display_name":"relapsed AML","score":0.8159999847412109},{"id":"https://openalex.org/keywords/chemotherapy-induced-senescence","display_name":"chemotherapy-induced senescence","score":0.9049999713897705},{"id":"https://openalex.org/keywords/leukemia-stem-cells","display_name":"leukemia stem cells","score":0.9120000004768372},{"id":"https://openalex.org/keywords/attenuated-total-reflectance","display_name":"ATR","score":0.625},{"id":"https://openalex.org/keywords/atr-inhibitors","display_name":"ATR inhibitors","score":0.9599999785423279},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.6830000281333923},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.7310000061988831},{"id":"https://openalex.org/keywords/engraftment-potential","display_name":"engraftment potential","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.836577296257019},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6180118918418884},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5567566156387329},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5514024496078491},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5347719788551331},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5289506912231445},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5043295621871948},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.495585560798645},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.44970935583114624},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3283883035182953},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.23866888880729675},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1749870777130127},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13023117184638977}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2159-8290.c.6549469.v1","doi":"https://doi.org/10.1158/2159-8290.c.6549469.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.c.6549469.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2159-8290.c.6549469.v1","doi":"https://doi.org/10.1158/2159-8290.c.6549469.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.c.6549469.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2592007767","https://openalex.org/W2026862129","https://openalex.org/W582905479","https://openalex.org/W2080599553","https://openalex.org/W2996239022","https://openalex.org/W2791511901","https://openalex.org/W2900494214","https://openalex.org/W2990397977","https://openalex.org/W2364732766","https://openalex.org/W1980883331"],"abstract_inverted_index":{"Abstract":[0],"Patients":[1],"with":[2,52,79,147,164],"acute":[3],"myeloid":[4],"leukemia":[5,57,67],"(AML)":[6],"frequently":[7],"relapse":[8,120,159,175],"after":[9,157],"chemotherapy,":[10,158],"yet":[11],"the":[12,174,180,209],"mechanism":[13,176],"by":[14,43,112,123],"which":[15,196],"AML":[16,27,107,119,140,178,197],"reemerges":[17],"is":[18,41,121,168,206],"not":[19],"fully":[20],"understood.":[21],"Herein,":[22],"we":[23,116,189],"show":[24],"that":[25,118,128],"primary":[26],"cells":[28,69,108,141,198],"enter":[29],"a":[30,124,191],"senescence-like":[31,81,98,125,192],"phenotype":[32,99,127,194],"following":[33],"chemotherapy":[34],"in":[35,38,70,73,161,177,208],"vitro":[36,71],"and":[37,47,56,72,75,88,92,104,179,201],"vivo.":[39],"This":[40,83,204,211],"accompanied":[42],"induction":[44],"of":[45,54,66,106,131,182],"senescence/inflammatory":[46],"embryonic":[48],"diapause":[49],"transcriptional":[50],"programs,":[51],"downregulation":[53],"MYC":[55],"stem":[58,68,133,149],"cell":[59,134,150],"genes.":[60],"Single-cell":[61],"RNA":[62],"sequencing":[63],"suggested":[64],"depletion":[65],"vivo,":[74],"enrichment":[76],"for":[77],"subpopulations":[78],"distinct":[80],"cells.":[82],"senescence":[84],"effect":[85],"was":[86,100,109],"transient":[87],"conferred":[89],"superior":[90],"colony-forming":[91],"engraftment":[93],"potential.":[94,151],"Entry":[95],"into":[96],"this":[97],"dependent":[101],"on":[102],"ATR,":[103],"persistence":[105],"severely":[110],"impaired":[111],"ATR":[113],"inhibitors.":[114],"Altogether,":[115],"propose":[117],"facilitated":[122],"resilience":[126,193],"occurs":[129,160],"regardless":[130],"their":[132],"status.":[135],"Upon":[136],"recovery,":[137],"these":[138],"post-senescence":[139],"give":[142],"rise":[143],"to":[144,172,185],"relapsed":[145],"AMLs":[146],"increased":[148],"Significance:":[152],"Despite":[153],"entering":[154],"complete":[155],"remission":[156],"many":[162],"patients":[163],"AML.":[165],"Thus,":[166],"there":[167],"an":[169],"urgent":[170],"need":[171],"understand":[173],"development":[181],"targeted":[183],"treatments":[184],"improve":[186],"outcome.":[187],"Here,":[188],"identified":[190],"through":[195],"can":[199],"survive":[200],"repopulate":[202],"leukemia.":[203],"article":[205],"highlighted":[207],"In":[210],"Issue":[212],"feature,":[213],"p.":[214],"1307":[215]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
