{"id":"https://openalex.org/W4362546079","doi":"https://doi.org/10.1158/2326-6066.c.6548762","title":"Data from Targeting CD20+ Aggressive B-cell Non\u2013Hodgkin Lymphoma by Anti-CD20 CAR mRNA-Modified Expanded Natural Killer Cells In Vitro and in NSG Mice","display_name":"Data from Targeting CD20+ Aggressive B-cell Non\u2013Hodgkin Lymphoma by Anti-CD20 CAR mRNA-Modified Expanded Natural Killer Cells In Vitro and in NSG Mice","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362546079","doi":"https://doi.org/10.1158/2326-6066.c.6548762"},"language":"en","primary_location":{"id":"doi:10.1158/2326-6066.c.6548762","doi":"https://doi.org/10.1158/2326-6066.c.6548762","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.c.6548762","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2326-6066.c.6548762","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111724951","display_name":"Yaya Chu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]},{"id":"https://openalex.org/I4210104060","display_name":"Maria Fareri Children's Hospital","ror":"https://ror.org/01gkp6p31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1321686444","https://openalex.org/I4210104060"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yaya Chu","raw_affiliation_strings":["Department of Pediatrics, Maria Fareri Children's Hospital, New York Medical College, Valhalla, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Maria Fareri Children's Hospital, New York Medical College, Valhalla, New York","institution_ids":["https://openalex.org/I181190671","https://openalex.org/I4210104060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109354308","display_name":"Jessica C. Hochberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]},{"id":"https://openalex.org/I4210104060","display_name":"Maria Fareri Children's Hospital","ror":"https://ror.org/01gkp6p31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1321686444","https://openalex.org/I4210104060"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Hochberg","raw_affiliation_strings":["Department of Pediatrics, Maria Fareri Children's Hospital, New York Medical College, Valhalla, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Maria Fareri Children's Hospital, New York Medical College, Valhalla, New York","institution_ids":["https://openalex.org/I181190671","https://openalex.org/I4210104060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049914171","display_name":"Ashlin Yahr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]},{"id":"https://openalex.org/I4210104060","display_name":"Maria Fareri Children's Hospital","ror":"https://ror.org/01gkp6p31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1321686444","https://openalex.org/I4210104060"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashlin Yahr","raw_affiliation_strings":["Department of Pediatrics, Maria Fareri Children's Hospital, New York Medical College, Valhalla, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Maria Fareri Children's Hospital, New York Medical College, Valhalla, New York","institution_ids":["https://openalex.org/I181190671","https://openalex.org/I4210104060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012947331","display_name":"Janet S Ayello","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]},{"id":"https://openalex.org/I4210104060","display_name":"Maria Fareri Children's Hospital","ror":"https://ror.org/01gkp6p31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1321686444","https://openalex.org/I4210104060"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet Ayello","raw_affiliation_strings":["Department of Pediatrics, Maria Fareri Children's Hospital, New York Medical College, Valhalla, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Maria Fareri Children's Hospital, New York Medical College, Valhalla, New York","institution_ids":["https://openalex.org/I181190671","https://openalex.org/I4210104060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075246827","display_name":"Carmella van de Ven","orcid":"https://orcid.org/0000-0001-7919-1089","observed_orcids":["https://orcid.org/0000-0001-7919-1089"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]},{"id":"https://openalex.org/I4210104060","display_name":"Maria Fareri Children's Hospital","ror":"https://ror.org/01gkp6p31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1321686444","https://openalex.org/I4210104060"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carmella van de Ven","raw_affiliation_strings":["Department of Pediatrics, Maria Fareri Children's Hospital, New York Medical College, Valhalla, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Maria Fareri Children's Hospital, New York Medical College, Valhalla, New York","institution_ids":["https://openalex.org/I181190671","https://openalex.org/I4210104060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077257353","display_name":"Matthew Barth","orcid":"https://orcid.org/0000-0002-4735-5859","observed_orcids":["https://orcid.org/0000-0002-4735-5859"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Barth","raw_affiliation_strings":["Department of Pediatrics, State University of New York at Buffalo, Buffalo, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, State University of New York at Buffalo, Buffalo, New York","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110554446","display_name":"Myron Stefan Czuczman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Myron Czuczman","raw_affiliation_strings":["Depart-ment of Immunology, Roswell Park Cancer Institute, Buffalo, New York","Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depart-ment of Immunology, Roswell Park Cancer Institute, Buffalo, New York","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001697191","display_name":"Mitchell Stuart Cairo","orcid":"https://orcid.org/0000-0002-2075-434X","observed_orcids":["https://orcid.org/0000-0002-2075-434X"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]},{"id":"https://openalex.org/I4210104060","display_name":"Maria Fareri Children's Hospital","ror":"https://ror.org/01gkp6p31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1321686444","https://openalex.org/I4210104060"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mitchell S. Cairo","raw_affiliation_strings":["Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York","Department of Medicine, New York Medical College, Valhalla, New York","Department of Microbiology and Immunology, New York Medical College, Valhalla, New York","Department of Pathology, New York Medical College, Valhalla, New York","Department of Pediatrics, Maria Fareri Children's Hospital, New York Medical College, Valhalla, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York","institution_ids":["https://openalex.org/I181190671"]},{"raw_affiliation_string":"Department of Medicine, New York Medical College, Valhalla, New York","institution_ids":["https://openalex.org/I181190671"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, New York Medical College, Valhalla, New York","institution_ids":["https://openalex.org/I181190671"]},{"raw_affiliation_string":"Department of Pathology, New York Medical College, Valhalla, New York","institution_ids":["https://openalex.org/I181190671"]},{"raw_affiliation_string":"Department of Pediatrics, Maria Fareri Children's Hospital, New York Medical College, Valhalla, New York","institution_ids":["https://openalex.org/I181190671","https://openalex.org/I4210104060"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5001697191"],"corresponding_institution_ids":["https://openalex.org/I181190671","https://openalex.org/I4210104060"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.08839999884366989,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd20","display_name":"CD20","score":0.7609999775886536},{"id":"https://openalex.org/keywords/b-cell-non-hodgkin-lymphoma","display_name":"B-cell non-Hodgkin lymphoma","score":0.9580000042915344},{"id":"https://openalex.org/keywords/car-nk-cells","display_name":"CAR-NK cells","score":0.5709999799728394},{"id":"https://openalex.org/keywords/rituximab-resistance","display_name":"rituximab resistance","score":0.8330000042915344},{"id":"https://openalex.org/keywords/nk-cell-degranulation","display_name":"NK cell degranulation","score":0.6570000052452087},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.6980000138282776},{"id":"https://openalex.org/keywords/xenograft-tumor-model","display_name":"xenograft tumor model","score":0.6290000081062317},{"id":"https://openalex.org/keywords/relapsed-refractory-lymphoma","display_name":"relapsed/refractory lymphoma","score":0.8610000014305115},{"id":"https://openalex.org/keywords/adoptive-immunotherapy","display_name":"adoptive immunotherapy","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C16232356","wikidata":"https://www.wikidata.org/wiki/Q4215980","display_name":"Raji cell","level":3,"score":0.6901252269744873},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5468964576721191},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.5183392763137817},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3957299292087555},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.3839320242404938},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3003482222557068},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2820069193840027},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.20265868306159973}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/2326-6066.c.6548762","doi":"https://doi.org/10.1158/2326-6066.c.6548762","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.c.6548762","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/2326-6066.c.6548762.v1","doi":"https://doi.org/10.1158/2326-6066.c.6548762.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.c.6548762.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2326-6066.c.6548762","doi":"https://doi.org/10.1158/2326-6066.c.6548762","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.c.6548762","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W6326026","https://openalex.org/W15360658","https://openalex.org/W1647534619","https://openalex.org/W1963522404","https://openalex.org/W1974184061","https://openalex.org/W1974816245","https://openalex.org/W1996408493","https://openalex.org/W2000871066","https://openalex.org/W2003911607","https://openalex.org/W2010607826","https://openalex.org/W2020646453","https://openalex.org/W2022069273","https://openalex.org/W2030381404","https://openalex.org/W2037633167","https://openalex.org/W2040478897","https://openalex.org/W2043843485","https://openalex.org/W2045820059","https://openalex.org/W2047846334","https://openalex.org/W2050529097","https://openalex.org/W2058015212","https://openalex.org/W2070120246","https://openalex.org/W2072063278","https://openalex.org/W2073300038","https://openalex.org/W2077362224","https://openalex.org/W2078519876","https://openalex.org/W2084825289","https://openalex.org/W2105400883","https://openalex.org/W2105557870","https://openalex.org/W2106263807","https://openalex.org/W2120344463","https://openalex.org/W2124982785","https://openalex.org/W2130011407","https://openalex.org/W2130338247","https://openalex.org/W2139399500","https://openalex.org/W2139539910","https://openalex.org/W2143561528","https://openalex.org/W2146313292","https://openalex.org/W2146494327","https://openalex.org/W2147068163","https://openalex.org/W2155127143","https://openalex.org/W2168753477","https://openalex.org/W2264636885","https://openalex.org/W2323613689"],"related_works":["https://openalex.org/W2027053879","https://openalex.org/W2980206906","https://openalex.org/W2980472035","https://openalex.org/W1979500942","https://openalex.org/W2515046620","https://openalex.org/W3193783001","https://openalex.org/W2565537694","https://openalex.org/W2023405922","https://openalex.org/W2967649956","https://openalex.org/W3212705830"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"prognosis":[2],"is":[3,23],"very":[4],"dismal":[5],"for":[6,206],"patients":[7,29,208],"with":[8,30,70,144,156,178,199,209],"relapsed":[9],"CD20+":[10,32,54,74,120,211],"B-cell":[11],"non-Hodgkin":[12],"lymphoma":[13],"(B-NHL).":[14],"Facilitating":[15],"the":[16,131,136,145,149,157,161,181,184],"development":[17],"of":[18,41,180],"alternative":[19],"novel":[20],"therapeutic":[21,204],"strategies":[22],"required":[24],"to":[25,119],"improve":[26],"outcomes":[27],"in":[28,56,59,66,114,117,135,148,153],"recurrent/refractory":[31],"B-NHL.":[33],"In":[34,123],"this":[35],"study,":[36],"we":[37],"investigated":[38],"functional":[39],"activities":[40],"anti-CD20":[42,200],"CAR-modified,":[43],"expanded":[44],"peripheral":[45],"blood":[46],"NK":[47],"cells":[48],"(exPBNK)":[49],"following":[50],"mRNA":[51],"nucleofection":[52],"against":[53,73,99],"B-NHL":[55],"vitro":[57,67],"and":[58,81,87,102,107,125,152,173,183],"vivo.":[60],"CAR+":[61,115,137],"exPBNK":[62,72,116],"had":[63,165],"significantly":[64,141,166],"enhanced":[65,113],"cytotoxicity,":[68],"compared":[69,143,177],"CAR\u2212":[71,158,185],"Ramos":[75],"(P":[76,89,170,188],"<":[77,90,171,189],"0.05),":[78],"Daudi,":[79],"Raji,":[80],"two":[82],"rituximab-resistant":[83],"cell":[84],"lines,":[85],"Raji-2R":[86],"Raji-4RH":[88],"0.001).":[91],"As":[92],"expected,":[93],"there":[94],"was":[95],"no":[96],"significant":[97],"difference":[98],"CD20\u2212":[100],"RS4;11":[101],"Jurkat":[103],"cells.":[104],"CD107a":[105],"degranulation":[106],"intracellular":[108],"IFN\u03b3":[109],"production":[110],"were":[111,140],"also":[112],"response":[118],"B-NHL\u2013specific":[121],"stimulation.":[122],"Raji-Luc":[124],"Raji-2R-Luc":[126],"xenografted":[127],"NOD/SCID/\u03b3-chain\u2212/\u2212":[128],"(NSG)":[129],"mice,":[130],"luciferase":[132],"signals":[133,146],"measured":[134,147],"exPBNK-treated":[138,163,186],"group":[139],"reduced,":[142],"untreated":[150,182],"mice":[151,154,164,187],"treated":[155],"exPBNK.":[159],"Furthermore,":[160],"CAR":[162,201],"extended":[167],"survival":[168],"time":[169],"0.001)":[172],"reduced":[174],"tumor":[175],"size,":[176],"those":[179],"0.05).":[190],"These":[191],"preclinical":[192],"data":[193],"suggest":[194],"that":[195],"ex":[196],"vivo\u2013exPBNK":[197],"modified":[198],"may":[202],"have":[203],"potential":[205],"treating":[207],"poor-risk":[210],"hematologic":[212],"malignancies.":[213],"Cancer":[214],"Immunol":[215],"Res;":[216],"3(4);":[217],"333\u201344.":[218],"\u00a92014":[219],"AACR.":[220]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-04-06T00:00:00"}
