{"id":"https://openalex.org/W4362545833","doi":"https://doi.org/10.1158/2326-6066.c.6548507.v1","title":"Data from STING Contributes to Antiglioma Immunity via Triggering Type I IFN Signals in the Tumor Microenvironment","display_name":"Data from STING Contributes to Antiglioma Immunity via Triggering Type I IFN Signals in the Tumor Microenvironment","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362545833","doi":"https://doi.org/10.1158/2326-6066.c.6548507.v1"},"language":"en","primary_location":{"id":"doi:10.1158/2326-6066.c.6548507.v1","doi":"https://doi.org/10.1158/2326-6066.c.6548507.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.c.6548507.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2326-6066.c.6548507.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058301324","display_name":"Takayuki Ohkuri","orcid":"https://orcid.org/0000-0002-6889-7809","observed_orcids":["https://orcid.org/0000-0002-6889-7809"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takayuki Ohkuri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086791516","display_name":"Arundhati Ghosh","orcid":"https://orcid.org/0000-0002-7083-8744","observed_orcids":["https://orcid.org/0000-0002-7083-8744"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arundhati Ghosh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048137834","display_name":"Akemi Kosaka","orcid":"https://orcid.org/0000-0001-5599-3685","observed_orcids":["https://orcid.org/0000-0001-5599-3685"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akemi Kosaka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100586106","display_name":"Jianzhong Zhu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jianzhong Zhu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042121198","display_name":"Maki Ikeura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maki Ikeura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Michael David","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael David","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088924932","display_name":"Simon C. Watkins","orcid":"https://orcid.org/0000-0003-4092-1552","observed_orcids":["https://orcid.org/0000-0003-4092-1552","https://orcid.org/0000-0003-0825-0795"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simon C. Watkins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052471392","display_name":"Saumendra N. Sarkar","orcid":"https://orcid.org/0000-0002-2850-6121","observed_orcids":["https://orcid.org/0000-0002-2850-6121"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saumendra N. Sarkar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5058793243","display_name":"Hideho Okada","orcid":"https://orcid.org/0000-0003-0076-9920","observed_orcids":["https://orcid.org/0000-0003-0076-9920"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hideho Okada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.031199999153614044,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.017799999564886093,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sting","display_name":"STING","score":0.9909999966621399},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.7860000133514404},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8100000023841858},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8970000147819519},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.9549999833106995},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9710000157356262},{"id":"https://openalex.org/keywords/c-di-gmp","display_name":"c-di-GMP","score":0.8019999861717224},{"id":"https://openalex.org/keywords/sting-agonist","display_name":"STING agonist","score":0.9440000057220459},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.6629999876022339},{"id":"https://openalex.org/keywords/cxcl10","display_name":"CXCL10","score":0.8379999995231628},{"id":"https://openalex.org/keywords/ccl5","display_name":"RANTES","score":0.996999979019165},{"id":"https://openalex.org/keywords/t-cell-migration","display_name":"T cell migration","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cd11b-gr1-cells","display_name":"CD11b+Gr1+ cells","score":0.7409999966621399}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5378889441490173},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.48096147179603577},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.433488667011261},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.4249991774559021},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36013978719711304},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.35069239139556885},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.290061891078949},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21818044781684875}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2326-6066.c.6548507.v1","doi":"https://doi.org/10.1158/2326-6066.c.6548507.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.c.6548507.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2326-6066.c.6548507.v1","doi":"https://doi.org/10.1158/2326-6066.c.6548507.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.c.6548507.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7100682009","https://openalex.org/W2026830644","https://openalex.org/W2331128627","https://openalex.org/W1582666737","https://openalex.org/W2914556331","https://openalex.org/W4327609264","https://openalex.org/W4408448669","https://openalex.org/W2591862469","https://openalex.org/W4389244652","https://openalex.org/W4416446722"],"abstract_inverted_index":{"Abstract":[0],"Although":[1],"type":[2,19,45,61,126,163,206],"I":[3,20,46,62,127,164,207],"IFNs":[4,21,63],"play":[5],"critical":[6],"roles":[7],"in":[8,24,50,68,210],"antiviral":[9],"and":[10,31,49,83,105,112,119,136,168,170,189,214],"antitumor":[11,140,201],"activity,":[12,141],"it":[13],"remains":[14],"to":[15,200],"be":[16],"elucidated":[17],"how":[18],"are":[22,56,65],"produced":[23],"sterile":[25],"conditions":[26],"of":[27,44,60,72,87,95,133,139,146,157,187,198,205,219,225],"the":[28,57,155,174,211,223,230],"tumor":[29,212],"microenvironment":[30,213],"directly":[32],"affect":[33],"tumor-infiltrating":[34],"immune":[35],"cells.":[36,117],"Mouse":[37],"de":[38],"novo":[39],"gliomas":[40],"show":[41],"increased":[42,99,137,184],"expression":[43,85],"IFN":[47,73,128,165,208],"messages,":[48],"mice,":[51],"CD11b+":[52,100],"brain-infiltrating":[53],"leukocytes":[54],"(BIL)":[55],"main":[58],"source":[59],"that":[64,123],"induced":[66],"partially":[67],"a":[69,147,216],"STING":[70,148,199,220],"(stimulator":[71],"genes)-dependent":[74],"manner.":[75],"Consequently,":[76],"glioma-bearing":[77,158],"StingGt/Gt":[78,96],"mice":[79,97,159],"showed":[80,98,130],"shorter":[81],"survival":[82,156],"lower":[84],"levels":[86,138],"Ifns":[88],"compared":[89],"with":[90,161,178,232],"wild-type":[91],"mice.":[92],"Furthermore,":[93],"BILs":[94,188],"Gr-1+":[101],"immature":[102],"myeloid":[103],"suppressor":[104],"CD25+":[106],"Foxp3+":[107],"regulatory":[108,134],"T":[109,116,121],"cells":[110,122],"(Treg)":[111],"decreased":[113],"IFN\u03b3-producing":[114],"CD8+":[115,120],"CD4+":[118],"received":[124],"direct":[125],"signals":[129],"lesser":[131],"degrees":[132],"activity":[135],"respectively.":[142],"Finally,":[143],"intratumoral":[144],"administration":[145],"agonist":[149],"(cyclic":[150],"diguanylate":[151],"monophosphate;":[152],"c-di-GMP)":[153],"improved":[154],"associated":[160],"enhanced":[162],"signaling,":[166],"Cxcl10":[167],"Ccl5,":[169],"T-cell":[171],"migration":[172],"into":[173],"brain.":[175],"In":[176],"combination":[177,231],"subcutaneous":[179],"OVA":[180],"peptide":[181],"vaccination,":[182],"c-di-GMP":[183],"OVA-specific":[185],"cytotoxicity":[186],"prolonged":[190],"their":[191],"survival.":[192],"These":[193],"data":[194],"demonstrate":[195],"significant":[196],"contributions":[197],"immunity":[202],"via":[203],"enhancement":[204],"signaling":[209],"suggest":[215],"potential":[217],"use":[218],"agonists":[221],"for":[222],"development":[224],"effective":[226],"immunotherapy,":[227],"such":[228],"as":[229],"antigen-specific":[233],"vaccinations.":[234],"Cancer":[235],"Immunol":[236],"Res;":[237],"2(12);":[238],"1199\u2013208.":[239],"\u00a92014":[240],"AACR.":[241]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2023-04-06T00:00:00"}