{"id":"https://openalex.org/W4362545758","doi":"https://doi.org/10.1158/2326-6066.c.6548200.v1","title":"Data from Antigen-Specific Bacterial Vaccine Combined with Anti-PD-L1 Rescues Dysfunctional Endogenous T Cells to Reject Long-Established Cancer","display_name":"Data from Antigen-Specific Bacterial Vaccine Combined with Anti-PD-L1 Rescues Dysfunctional Endogenous T Cells to Reject Long-Established Cancer","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362545758","doi":"https://doi.org/10.1158/2326-6066.c.6548200.v1"},"language":"en","primary_location":{"id":"doi:10.1158/2326-6066.c.6548200.v1","doi":"https://doi.org/10.1158/2326-6066.c.6548200.v1","is_oa":true,"landing_page_url":"http://doi.org/10.1158/2326-6066.c.6548200.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://doi.org/10.1158/2326-6066.c.6548200.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102910163","display_name":"David C. Binder","orcid":"https://orcid.org/0000-0003-4400-5455","observed_orcids":["https://orcid.org/0000-0003-4400-5455"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"David C. Binder","raw_affiliation_strings":["Cancer Biology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029751531","display_name":"Boris Engels","orcid":"https://orcid.org/0000-0001-9682-2954","observed_orcids":["https://orcid.org/0000-0001-9682-2954"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Boris Engels","raw_affiliation_strings":["Departments of 3 Pathology,","Immunology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 3 Pathology,","institution_ids":[]},{"raw_affiliation_string":"Immunology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054951638","display_name":"Ainhoa Arina","orcid":"https://orcid.org/0000-0002-0585-7148","observed_orcids":["https://orcid.org/0000-0002-0585-7148"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ainhoa Arina","raw_affiliation_strings":["Departments of 3 Pathology,","Immunology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 3 Pathology,","institution_ids":[]},{"raw_affiliation_string":"Immunology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111502463","display_name":"Ping Yu","orcid":"https://orcid.org/0000-0002-6096-1933","observed_orcids":["https://orcid.org/0000-0002-6096-1933","https://orcid.org/0009-0000-7977-9472"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ping Yu","raw_affiliation_strings":["Departments of 3 Pathology,","Immunology,","Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 3 Pathology,","institution_ids":[]},{"raw_affiliation_string":"Immunology,","institution_ids":[]},{"raw_affiliation_string":"Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053650805","display_name":"James M. Slauch","orcid":"https://orcid.org/0000-0003-4634-9702","observed_orcids":["https://orcid.org/0000-0003-4634-9702"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James M. Slauch","raw_affiliation_strings":["Department of Microbi-ology, College of Medicine, University of Illinois, Urbana, Illinois;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbi-ology, College of Medicine, University of Illinois, Urbana, Illinois;","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035676180","display_name":"Yang\u2010Xin Fu","orcid":"https://orcid.org/0000-0001-8441-6617","observed_orcids":["https://orcid.org/0000-0001-8441-6617","https://orcid.org/0000-0002-4809-825X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yang-Xin Fu","raw_affiliation_strings":["Departments of 3 Pathology,","Immunology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 3 Pathology,","institution_ids":[]},{"raw_affiliation_string":"Immunology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038171309","display_name":"Theodore G Karrison","orcid":"https://orcid.org/0009-0009-8641-5111","observed_orcids":["https://orcid.org/0009-0009-8641-5111"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Theodore Karrison","raw_affiliation_strings":["Health Sciences, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Sciences, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076906514","display_name":"Byron Burnette","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Byron Burnette","raw_affiliation_strings":["Radiation Oncology, The University of Chicago, Chicago;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology, The University of Chicago, Chicago;","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110615244","display_name":"Christian Idel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Idel","raw_affiliation_strings":["Depart-ment of Otorhinolaryngology, University of L\u20ac ubeck, L\u20ac ubeck, Germany;","Departments of 3 Pathology,","Immunology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Depart-ment of Otorhinolaryngology, University of L\u20ac ubeck, L\u20ac ubeck, Germany;","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"Departments of 3 Pathology,","institution_ids":[]},{"raw_affiliation_string":"Immunology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100748391","display_name":"Ming Zhao","orcid":"https://orcid.org/0000-0002-4728-9206","observed_orcids":["https://orcid.org/0000-0002-4728-9206"]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming Zhao","raw_affiliation_strings":["AntiCancer, Inc.;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer, Inc.;","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040819666","display_name":"Robert M. Hoffman","orcid":"https://orcid.org/0000-0002-0049-0041","observed_orcids":["https://orcid.org/0000-0002-0049-0041"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Hoffman","raw_affiliation_strings":["AntiCancer, Inc.;","Department of Surgery, University of California San Diego, San Diego, California;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer, Inc.;","institution_ids":["https://openalex.org/I4210121314"]},{"raw_affiliation_string":"Department of Surgery, University of California San Diego, San Diego, California;","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011462362","display_name":"David H. Munn","orcid":"https://orcid.org/0000-0002-7711-2858","observed_orcids":["https://orcid.org/0000-0002-7711-2858"]},"institutions":[{"id":"https://openalex.org/I4210087454","display_name":"Augusta University Health","ror":"https://ror.org/007rawr89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David H. Munn","raw_affiliation_strings":["Georgia Health Sciences University Cancer Center, Augusta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgia Health Sciences University Cancer Center, Augusta, Georgia","institution_ids":["https://openalex.org/I4210087454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042304495","display_name":"Donald A. Rowley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald A. Rowley","raw_affiliation_strings":["Department of Pathology, The University of Chicago, Room G-304, MC 3008, 5841 South Maryland Avenue, Chicago, IL 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The University of Chicago, Room G-304, MC 3008, 5841 South Maryland Avenue, Chicago, IL 60637","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000018452","display_name":"Hans Wilhelm Schreiber","orcid":"https://orcid.org/0000-0002-1908-6233","observed_orcids":["https://orcid.org/0000-0002-1908-6233"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hans Schreiber","raw_affiliation_strings":["Cancer Biology and","Departments of 3 Pathology,","Immunology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology and","institution_ids":[]},{"raw_affiliation_string":"Departments of 3 Pathology,","institution_ids":[]},{"raw_affiliation_string":"Immunology,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5102910163"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.07850000262260437,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salmonella-typhimurium-a1-r","display_name":"Salmonella typhimurium A1-R","score":0.843999981880188},{"id":"https://openalex.org/keywords/pd-l1-inhibitors","display_name":"PD-L1 inhibitors","score":0.8669999837875366},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.6840000152587891},{"id":"https://openalex.org/keywords/cd8-t-cell-dysfunction","display_name":"CD8+ T cell dysfunction","score":0.7739999890327454},{"id":"https://openalex.org/keywords/tumor-specific-t-cells","display_name":"tumor-specific T cells","score":0.6980000138282776},{"id":"https://openalex.org/keywords/ctla-4-blockade","display_name":"CTLA-4 blockade","score":0.9160000085830688},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7990000247955322},{"id":"https://openalex.org/keywords/tumor-rejection","display_name":"tumor rejection","score":0.531000018119812},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6616392135620117},{"id":"https://openalex.org/C2776662205","wikidata":"https://www.wikidata.org/wiki/Q2459684","display_name":"Tumor antigen","level":4,"score":0.5785648822784424},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.573182225227356},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5494994521141052},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.48929473757743835},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47728410363197327},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.44992387294769287},{"id":"https://openalex.org/C2778326572","wikidata":"https://www.wikidata.org/wiki/Q7852668","display_name":"Tumor-infiltrating lymphocytes","level":4,"score":0.42426779866218567},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.416595458984375},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4105921983718872},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.356974720954895},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3482939600944519},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3415025472640991},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.34115666151046753},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10736066102981567},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08635362982749939}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2326-6066.c.6548200.v1","doi":"https://doi.org/10.1158/2326-6066.c.6548200.v1","is_oa":true,"landing_page_url":"http://doi.org/10.1158/2326-6066.c.6548200.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2326-6066.c.6548200.v1","doi":"https://doi.org/10.1158/2326-6066.c.6548200.v1","is_oa":true,"landing_page_url":"http://doi.org/10.1158/2326-6066.c.6548200.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1576543020","https://openalex.org/W1816486083","https://openalex.org/W1979507175","https://openalex.org/W1983143892","https://openalex.org/W1983664228","https://openalex.org/W1998994531","https://openalex.org/W2016789384","https://openalex.org/W2023357108","https://openalex.org/W2033048068","https://openalex.org/W2053353274","https://openalex.org/W2057893793","https://openalex.org/W2070748533","https://openalex.org/W2076948707","https://openalex.org/W2084323507","https://openalex.org/W2087304127","https://openalex.org/W2094366129","https://openalex.org/W2096825083","https://openalex.org/W2097855813","https://openalex.org/W2101653483","https://openalex.org/W2102575291","https://openalex.org/W2108052503","https://openalex.org/W2109664742","https://openalex.org/W2112016055","https://openalex.org/W2113537295","https://openalex.org/W2115241901","https://openalex.org/W2115525561","https://openalex.org/W2130011407","https://openalex.org/W2131577873","https://openalex.org/W2135339053","https://openalex.org/W2137776620","https://openalex.org/W2139551778","https://openalex.org/W2145303132","https://openalex.org/W2150565980","https://openalex.org/W2159124392","https://openalex.org/W2160834915","https://openalex.org/W2166329890","https://openalex.org/W2169161650","https://openalex.org/W4238423864","https://openalex.org/W4238570296","https://openalex.org/W4246098669"],"related_works":["https://openalex.org/W2108712362","https://openalex.org/W3173556444","https://openalex.org/W2534772180","https://openalex.org/W2118378412","https://openalex.org/W1495788311","https://openalex.org/W2955170235","https://openalex.org/W2111217091","https://openalex.org/W2476999556","https://openalex.org/W4362546118","https://openalex.org/W4400214309"],"abstract_inverted_index":{"Abstract":[0],"Immunogenic":[1],"tumors":[2,49,61],"grow":[3],"progressively":[4],"even":[5],"when":[6],"heavily":[7],"infiltrated":[8],"by":[9],"CD8+":[10,18,34,83,128,152,175],"T":[11,35,129,153,176],"cells.":[12],"We":[13,53],"investigated":[14],"how":[15],"to":[16,67,106,170],"rescue":[17,171],"T-cell":[19,84],"function":[20,95],"in":[21,89,98,112,138,157],"long-established":[22,116],"immunogenic":[23,117,181],"melanomas":[24],"that":[25,37],"contained":[26],"a":[27,73,133,165],"high":[28,134],"percentage":[29],"of":[30,115,126,136,150],"endogenous":[31,81,173],"PD-1+":[32],"tumor-specific":[33,57,82,127,151,174],"cells":[36,130,154,177],"were":[38],"dysfunctional.":[39],"Treatment":[40,101],"with":[41,102,121,144],"\u03b1PD-L1\u2013":[42],"and":[43,71,93,110,155,178],"\u03b1CTLA-4\u2013blocking":[44],"antibodies":[45],"did":[46],"not":[47],"prevent":[48],"from":[50],"progressing":[51],"rapidly.":[52],"then":[54],"tested":[55],"exogenous":[56],"antigen":[58,69],"delivery":[59],"into":[60],"using":[62],"Salmonella":[63],"Typhimurium":[64],"A1-R":[65,78,104,143],"(A1-R)":[66],"increase":[68],"levels":[70],"generate":[72],"proinflammatory":[74],"tumor":[75,159],"microenvironment.":[76],"Antigen-producing":[77],"rescued":[79],"the":[80,90,99,124,139,148],"response:":[85],"Proliferation":[86],"was":[87,96],"induced":[88],"lymphoid":[91],"organs":[92],"effector":[94],"recovered":[97],"tumor.":[100,140],"antigen-producing":[103,122,142],"led":[105],"improved":[107],"mouse":[108],"survival":[109],"resulted":[111,156],"32%":[113],"rejection":[114],"melanomas.":[118],"Following":[119],"treatment":[120],"A1-R,":[123],"majority":[125],"still":[131],"expressed":[132],"level":[135],"PD-1":[137],"Combining":[141],"\u03b1PD-L1-blocking":[145],"antibody":[146],"enhanced":[147],"expansion":[149],"80%":[158],"rejection.":[160],"Collectively,":[161],"these":[162],"data":[163],"show":[164],"powerful":[166],"new":[167],"therapeutic":[168],"approach":[169],"dysfunctional":[172],"eradicate":[179],"advanced":[180],"tumors.":[182],"Cancer":[183],"Immunol":[184],"Res;":[185],"1(2);":[186],"123\u201333.":[187],"\u00a92013":[188],"AACR.":[189]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2023-04-06T00:00:00"}
