{"id":"https://openalex.org/W4362545372","doi":"https://doi.org/10.1158/1541-7786.c.6539487","title":"Data from Bioactive Lipids S1P and C1P Are Prometastatic Factors in Human Rhabdomyosarcoma, and Their Tissue Levels Increase in Response to Radio/Chemotherapy","display_name":"Data from Bioactive Lipids S1P and C1P Are Prometastatic Factors in Human Rhabdomyosarcoma, and Their Tissue Levels Increase in Response to Radio/Chemotherapy","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362545372","doi":"https://doi.org/10.1158/1541-7786.c.6539487"},"language":"en","primary_location":{"id":"doi:10.1158/1541-7786.c.6539487","doi":"https://doi.org/10.1158/1541-7786.c.6539487","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.6539487","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1541-7786.c.6539487","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039200324","display_name":"Gabriela Schneider","orcid":"https://orcid.org/0000-0003-2088-8695","observed_orcids":["https://orcid.org/0000-0003-2088-8695"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriela Schneider","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007429066","display_name":"Ewa Bryndza","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ewa Bryndza","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065042621","display_name":"Ahmed Abdel\u2010Latif","orcid":"https://orcid.org/0000-0002-8178-7102","observed_orcids":["https://orcid.org/0000-0002-8178-7102"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ahmed Abdel-Latif","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026426787","display_name":"Janina Ratajczak","orcid":"https://orcid.org/0000-0001-8605-8892","observed_orcids":["https://orcid.org/0000-0001-8605-8892"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janina Ratajczak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062190931","display_name":"Magdalena A. Maj","orcid":"https://orcid.org/0000-0003-3511-3788","observed_orcids":["https://orcid.org/0000-0003-3511-3788"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Magdalena Maj","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037181676","display_name":"Maciej Tarnowski","orcid":"https://orcid.org/0000-0002-3869-5077","observed_orcids":["https://orcid.org/0000-0002-3869-5077"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maciej Tarnowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038463202","display_name":"Yuri M. Klyachkin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuri M. Klyachkin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109173471","display_name":"Peter J. Houghton","orcid":"https://orcid.org/0000-0002-2400-8184","observed_orcids":["https://orcid.org/0000-0002-2400-8184"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Houghton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060684279","display_name":"Andrew J. Morris","orcid":"https://orcid.org/0000-0003-1910-4865","observed_orcids":["https://orcid.org/0000-0003-1910-4865"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew J. Morris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011976652","display_name":"Axel Vater","orcid":"https://orcid.org/0000-0003-4166-982X","observed_orcids":["https://orcid.org/0000-0003-4166-982X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Axel Vater","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115588097","display_name":"Sven Klu\u00dfmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sven Klussmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008165057","display_name":"Magda Kucia","orcid":"https://orcid.org/0000-0002-9110-5048","observed_orcids":["https://orcid.org/0000-0002-9110-5048"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Magdalena Kucia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5060515541","display_name":"Mariusz Z. Ratajczak","orcid":"https://orcid.org/0000-0002-0071-0198","observed_orcids":["https://orcid.org/0000-0002-0071-0198","https://orcid.org/0000-0002-7255-4980"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mariusz Z. Ratajczak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rhabdomyosarcoma","display_name":"rhabdomyosarcoma","score":0.9139999747276306},{"id":"https://openalex.org/keywords/sphingosine-1-phosphate","display_name":"sphingosine-1-phosphate","score":0.9909999966621399},{"id":"https://openalex.org/keywords/ceramide-1-phosphate","display_name":"ceramide-1-phosphate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bioactive-lipids","display_name":"bioactive lipids","score":0.9810000061988831},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7519999742507935},{"id":"https://openalex.org/keywords/tumor-cell-motility","display_name":"tumor cell motility","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.9549999833106995},{"id":"https://openalex.org/keywords/sdf-1-cxcl12","display_name":"SDF-1/CXCL12","score":0.8460000157356262},{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.9559999704360962},{"id":"https://openalex.org/keywords/radiotherapy-complications","display_name":"radiotherapy complications","score":0.6909999847412109},{"id":"https://openalex.org/keywords/chemotherapy-side-effects","display_name":"chemotherapy side effects","score":0.972000002861023},{"id":"https://openalex.org/keywords/spiegelmers","display_name":"Spiegelmers","score":0.902999997138977},{"id":"https://openalex.org/keywords/gamma-irradiation","display_name":"gamma irradiation","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C2780844630","wikidata":"https://www.wikidata.org/wiki/Q1898141","display_name":"Rhabdomyosarcoma","level":3,"score":0.6195708513259888},{"id":"https://openalex.org/C2776996007","wikidata":"https://www.wikidata.org/wiki/Q2399112","display_name":"Hepatocyte growth factor","level":3,"score":0.6017819046974182},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.571888267993927},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5021584033966064},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4650638699531555},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.44882306456565857},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.44427913427352905},{"id":"https://openalex.org/C2776596873","wikidata":"https://www.wikidata.org/wiki/Q418267","display_name":"Sphingosine-1-phosphate","level":4,"score":0.43931084871292114},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.41594937443733215},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.41289377212524414},{"id":"https://openalex.org/C2778703144","wikidata":"https://www.wikidata.org/wiki/Q46298","display_name":"Sphingosine","level":3,"score":0.40272653102874756},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36421269178390503},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3548191785812378},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33979126811027527},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19012239575386047},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.16148406267166138},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14116990566253662},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12990158796310425},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08312425017356873},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1541-7786.c.6539487","doi":"https://doi.org/10.1158/1541-7786.c.6539487","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.6539487","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1541-7786.c.6539487.v1","doi":"https://doi.org/10.1158/1541-7786.c.6539487.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.6539487.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1541-7786.c.6539487","doi":"https://doi.org/10.1158/1541-7786.c.6539487","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.6539487","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2150541225","https://openalex.org/W4300619177","https://openalex.org/W2563556257","https://openalex.org/W4362493620","https://openalex.org/W2146256698","https://openalex.org/W2609022571","https://openalex.org/W4362639143","https://openalex.org/W2150691476","https://openalex.org/W3193952483","https://openalex.org/W2596025630"],"abstract_inverted_index":{"Abstract":[0],"Evidence":[1],"suggests":[2],"that":[3,18,91,119,140,150],"bioactive":[4,20,51,151],"lipids":[5,152],"may":[6],"regulate":[7],"pathophysiologic":[8],"functions":[9],"such":[10,74],"as":[11,75],"cancer":[12],"cell":[13],"metastasis.":[14],"Therefore,":[15],"we":[16,117],"determined":[17],"the":[19,30,64,92,120,136,164],"lipid":[21],"chemoattractants":[22],"sphingosine-1-phosphate":[23],"(S1P)":[24],"and":[25,34,59,96,161],"ceramide-1-phosphate":[26],"(C1P)":[27],"strongly":[28],"enhanced":[29],"in":[31,56,67,100,125,133,157],"vitro":[32],"motility":[33],"adhesion":[35],"of":[36,94,122,159,168],"human":[37],"rhabdomyosarcoma":[38],"(RMS)":[39],"cells.":[40],"Importantly,":[41],"this":[42],"effect":[43],"was":[44],"observed":[45,66],"at":[46],"physiologic":[47],"concentrations":[48],"for":[49],"both":[50],"lipids,":[52],"which":[53,107],"are":[54],"present":[55,88],"biologic":[57],"fluids,":[58],"were":[60,98],"much":[61],"stronger":[62],"than":[63],"effects":[65,167],"response":[68,126],"to":[69,114,127,163],"known":[70],"RMS":[71,123,160],"prometastatic":[72,111,173],"factors":[73],"stromal":[76],"derived":[77],"factors-1":[78],"(SDF-1/CXCL12)":[79],"or":[80,105],"hepatocyte":[81],"growth":[82],"factor/scatter":[83],"factor":[84],"(HGF/SF).":[85],"We":[86],"also":[87],"novel":[89],"evidence":[90],"levels":[93],"S1P":[95,128],"C1P":[97],"increased":[99],"several":[101],"organs":[102],"after":[103],"\u03b3-irradiation":[104],"chemotherapy,":[106],"indicates":[108],"an":[109],"unwanted":[110,165],"environment":[112],"related":[113],"treatment.":[115],"Critically,":[116],"found":[118],"metastasis":[121],"cells":[124],"can":[129],"be":[130],"effectively":[131],"inhibited":[132],"vivo":[134],"with":[135],"S1P-specific":[137],"binder":[138],"NOX-S93":[139],"is":[141],"based":[142],"on":[143],"a":[144,154,172],"high-affinity":[145],"Spiegelmer.":[146],"These":[147],"data":[148],"indicate":[149],"play":[153],"vital":[155],"role":[156],"dissemination":[158],"contribute":[162],"side":[166],"radio/chemotherapy":[169],"by":[170],"creating":[171],"microenvironment.":[174],"Mol":[175],"Cancer":[176],"Res;":[177],"11(7);":[178],"793\u2013807.":[179],"\u00a92013":[180],"AACR.":[181]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-06T00:00:00"}