{"id":"https://openalex.org/W4362545351","doi":"https://doi.org/10.1158/1940-6207.c.6547307","title":"Data from ProDiet: A Phase II Randomized Placebo-controlled Trial of Green Tea Catechins and Lycopene in Men at Increased Risk of Prostate Cancer","display_name":"Data from ProDiet: A Phase II Randomized Placebo-controlled Trial of Green Tea Catechins and Lycopene in Men at Increased Risk of Prostate Cancer","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362545351","doi":"https://doi.org/10.1158/1940-6207.c.6547307"},"language":"en","primary_location":{"id":"doi:10.1158/1940-6207.c.6547307","doi":"https://doi.org/10.1158/1940-6207.c.6547307","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.c.6547307","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1940-6207.c.6547307","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"J. Athene Lane","orcid":"https://orcid.org/0000-0003-4581-9346","observed_orcids":["https://orcid.org/0000-0003-4581-9346"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Athene Lane","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4581-9346","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071130679","display_name":"Vanessa Er","orcid":"https://orcid.org/0000-0002-0649-1846","observed_orcids":["https://orcid.org/0000-0002-0649-1846"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vanessa Er","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040091822","display_name":"KERRY N. L. AVERY","orcid":"https://orcid.org/0000-0001-5477-2418","observed_orcids":["https://orcid.org/0000-0001-5477-2418"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kerry N.L. Avery","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5477-2418","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054114945","display_name":"Jeremy P. Horwood","orcid":"https://orcid.org/0000-0001-7092-4960","observed_orcids":["https://orcid.org/0000-0001-7092-4960"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeremy Horwood","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015484587","display_name":"Marie M. Cantwell","orcid":"https://orcid.org/0009-0000-4756-2172","observed_orcids":["https://orcid.org/0009-0000-4756-2172"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marie Cantwell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Gema P. Caro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gema P. Caro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062888766","display_name":"Alan Crozier","orcid":"https://orcid.org/0000-0001-7581-6782","observed_orcids":["https://orcid.org/0000-0001-7581-6782"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alan Crozier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013184354","display_name":"George Davey Smith","orcid":"https://orcid.org/0000-0002-1407-8314","observed_orcids":["https://orcid.org/0000-0002-1407-8314"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George Davey Smith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049636639","display_name":"Jenny Donovan","orcid":"https://orcid.org/0000-0002-6488-5472","observed_orcids":["https://orcid.org/0000-0002-6488-5472"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jenny L. Donovan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6488-5472","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036488573","display_name":"Liz Down","orcid":"https://orcid.org/0000-0002-2738-2710","observed_orcids":["https://orcid.org/0000-0002-2738-2710"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liz Down","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012694886","display_name":"Freddie Charles Hamdy","orcid":"https://orcid.org/0000-0003-2627-2154","observed_orcids":["https://orcid.org/0000-0003-2627-2154"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Freddie C. Hamdy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010429410","display_name":"David A Gillatt","orcid":"https://orcid.org/0000-0003-4581-9346","observed_orcids":["https://orcid.org/0000-0003-4581-9346"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Gillatt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054967084","display_name":"Jeff M.P. Holly","orcid":"https://orcid.org/0000-0003-0786-0305","observed_orcids":["https://orcid.org/0000-0003-0786-0305"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeff Holly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087023732","display_name":"Rhiannon C Macefield","orcid":"https://orcid.org/0000-0002-6606-5427","observed_orcids":["https://orcid.org/0000-0002-6606-5427"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rhiannon Macefield","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035680605","display_name":"Hilary Moody","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hilary Moody","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090783984","display_name":"David Edgar Neal","orcid":"https://orcid.org/0000-0002-6033-5086","observed_orcids":["https://orcid.org/0000-0002-6033-5086"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David E. Neal","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6033-5086","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023577572","display_name":"Eleanor I. Walsh","orcid":"https://orcid.org/0000-0001-7696-3661","observed_orcids":["https://orcid.org/0000-0001-7696-3661"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eleanor Walsh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065571043","display_name":"Richard Michael Martin","orcid":"https://orcid.org/0000-0002-7992-7719","observed_orcids":["https://orcid.org/0000-0002-7992-7719"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard M. Martin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7992-7719","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5078250568","display_name":"Chris Metcalfe","orcid":"https://orcid.org/0000-0001-8318-8907","observed_orcids":["https://orcid.org/0000-0001-8318-8907"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chris Metcalfe","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8318-8907","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.6054999828338623,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.6054999828338623,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11411","display_name":"Tea Polyphenols and Effects","score":0.09440000355243683,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.059300001710653305,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer-chemoprevention","display_name":"prostate cancer chemoprevention","score":0.9169999957084656},{"id":"https://openalex.org/keywords/green-tea-catechins","display_name":"green tea catechins","score":0.972000002861023},{"id":"https://openalex.org/keywords/epigallocatechin-gallate","display_name":"epigallocatechin gallate","score":0.9779999852180481},{"id":"https://openalex.org/keywords/lycopene","display_name":"lycopene","score":0.9929999709129333},{"id":"https://openalex.org/keywords/dietary-intervention","display_name":"dietary intervention","score":0.45100000500679016},{"id":"https://openalex.org/keywords/prostate-specific-antigen","display_name":"prostate-specific antigen","score":0.7680000066757202},{"id":"https://openalex.org/keywords/intervention-feasibility-and-acceptability","display_name":"intervention feasibility and acceptability","score":0.7039999961853027},{"id":"https://openalex.org/keywords/intervention-adherence","display_name":"intervention adherence","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C2780022147","wikidata":"https://www.wikidata.org/wiki/Q208130","display_name":"Lycopene","level":3,"score":0.9213874340057373},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7377611994743347},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7245066165924072},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.6425976753234863},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.607302725315094},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5055315494537354},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5037705302238464},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.4984104633331299},{"id":"https://openalex.org/C2777926168","wikidata":"https://www.wikidata.org/wiki/Q484083","display_name":"Green tea extract","level":3,"score":0.44945991039276123},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.41808170080184937},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3935156762599945},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2458740770816803},{"id":"https://openalex.org/C2992814287","wikidata":"https://www.wikidata.org/wiki/Q484083","display_name":"Green tea","level":2,"score":0.24184241890907288},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.1848989725112915},{"id":"https://openalex.org/C28781525","wikidata":"https://www.wikidata.org/wiki/Q191907","display_name":"Carotenoid","level":2,"score":0.1445058286190033},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07730355858802795},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1940-6207.c.6547307","doi":"https://doi.org/10.1158/1940-6207.c.6547307","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.c.6547307","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1940-6207.c.6547307.v1","doi":"https://doi.org/10.1158/1940-6207.c.6547307.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.c.6547307.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1940-6207.c.6547307","doi":"https://doi.org/10.1158/1940-6207.c.6547307","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.c.6547307","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2897590379","https://openalex.org/W4252392068","https://openalex.org/W1998184944","https://openalex.org/W2152588471","https://openalex.org/W2911962525","https://openalex.org/W2066275289","https://openalex.org/W2120276969","https://openalex.org/W2906602106","https://openalex.org/W2159916622","https://openalex.org/W2896581114"],"abstract_inverted_index":{"Abstract":[0],"Epidemiologic":[1],"studies":[2],"suggest":[3],"that":[4,238],"diet":[5,169],"can":[6],"alter":[7],"prostate":[8,29,46,232],"cancer":[9],"risk.":[10],"This":[11,234],"study":[12],"aimed":[13],"to":[14,54,129,227],"establish":[15],"the":[16,152,167,186,198,221],"feasibility":[17],"and":[18,58,76,96,117,132,156,190,215],"acceptability":[19,110],"of":[20,28,38,101,109,121,123,231],"dietary":[21],"modification":[22],"in":[23,151,166,184,185,197],"men":[24,126,219,228],"at":[25,103,229],"increased":[26],"risk":[27,230],"cancer.":[30,233],"Men":[31],"were":[32,93,134,213],"invited":[33],"with":[34,44,106,172,204],"a":[35,239],"PSA":[36],"level":[37],"2.0\u20132.95":[39],"ng/mL":[40,43],"or":[41,66,74,80,86],"3.0\u201319.95":[42],"negative":[45],"biopsies.":[47],"Randomization":[48],"(3":[49,63],"\u00d7":[50],"3":[51],"factorial":[52],"design)":[53],"daily":[55],"green":[56,60,199],"tea":[57,61,200],"lycopene:":[59],"drink":[62,201],"cups,":[64],"unblinded)":[65],"capsules":[67,81,206],"[blinded,":[68],"600":[69],"mg":[70,84],"flavan-3-ol":[71],"()-epigallocatechin-3-gallate":[72],"(EGCG)":[73],"placebo]":[75],"lycopene-rich":[77],"foods":[78],"(unblinded)":[79],"(blinded,":[82],"15":[83],"lycopene":[85,138,153],"placebo)":[87],"for":[88],"6":[89,104],"months.":[90],"Primary":[91],"endpoints":[92,108],"randomization":[94],"rates":[95],"intervention":[97,235],"adherence":[98],"(blinded":[99],"assessment":[100],"metabolites)":[102],"months":[105],"secondary":[107],"(from":[111],"interviews),":[112],"safety,":[113],"weight,":[114],"blood":[115],"pressure,":[116],"PSA.":[118],"A":[119],"total":[120],"133":[122],"469":[124],"(28.4%)":[125],"approached":[127],"agreed":[128],"be":[130],"randomized":[131],"132":[133],"followed-up":[135],"(99.2%).":[136],"Mean":[137],"was":[139,177],"1.28":[140],"[95%":[141],"confidence":[142],"intervals":[143],"(CI),":[144],"1.09\u20131.50,":[145],"P":[146,161,208],"=":[147],"0.003]":[148],"times":[149,164],"higher":[150,165,183,196],"capsule":[154,188],"group":[155,170,189,202],"1.42":[157],"(95%":[158,180,193],"CI,":[159,181,194],"1.21\u20131.66;":[160],"<":[162,209],"0.001)":[163],"lycopene-enriched":[168],"compared":[171,203],"placebo":[173,205],"capsules.":[174,222],"Median":[175],"EGCG":[176],"10.7":[178],"nmol/L":[179,192],"7.0\u201332.0)":[182],"active":[187],"20.0":[191],"0.0\u201319.0)":[195],"(both":[207],"0.001).":[210],"All":[211],"interventions":[212],"acceptable":[214,226],"well":[216],"tolerated":[217],"although":[218],"preferred":[220],"Dietary":[223],"prevention":[224],"is":[225,243],"trial":[236,242],"demonstrates":[237],"chemoprevention":[240],"clinical":[241],"feasible.":[244],"Cancer":[245],"Prev":[246],"Res;":[247],"11(11);":[248],"687\u201396.":[249],"\u00a92018":[250],"AACR.":[251]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2023-04-06T00:00:00"}
