{"id":"https://openalex.org/W4362545322","doi":"https://doi.org/10.1158/1541-7786.c.6539668","title":"Data from The HER2- and Heregulin \u03b21 (HRG)\u2013Inducible TNFR Superfamily Member Fn14 Promotes HRG-Driven Breast Cancer Cell Migration, Invasion, and MMP9 Expression","display_name":"Data from The HER2- and Heregulin \u03b21 (HRG)\u2013Inducible TNFR Superfamily Member Fn14 Promotes HRG-Driven Breast Cancer Cell Migration, Invasion, and MMP9 Expression","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362545322","doi":"https://doi.org/10.1158/1541-7786.c.6539668"},"language":"en","primary_location":{"id":"doi:10.1158/1541-7786.c.6539668","doi":"https://doi.org/10.1158/1541-7786.c.6539668","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1541-7786.c.6539668","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1541-7786.c.6539668","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014074616","display_name":"Kaushal V. Asrani","orcid":"https://orcid.org/0000-0002-9777-5296","observed_orcids":["https://orcid.org/0000-0002-9777-5296"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kaushal Asrani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020136425","display_name":"Ruth A. Keri","orcid":"https://orcid.org/0000-0002-1640-3088","observed_orcids":["https://orcid.org/0000-0002-1640-3088"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruth A. Keri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059330249","display_name":"Rebeca Galisteo","orcid":"https://orcid.org/0000-0002-8534-4800","observed_orcids":["https://orcid.org/0000-0002-8534-4800"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rebeca Galisteo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050068409","display_name":"Sharron A.N. Brown","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sharron A.N. Brown","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108700277","display_name":"Sarah J. Morgan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarah J. Morgan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086791516","display_name":"Arundhati Ghosh","orcid":"https://orcid.org/0000-0002-7083-8744","observed_orcids":["https://orcid.org/0000-0002-7083-8744"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arundhati Ghosh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016790638","display_name":"Nhan L. Tran","orcid":"https://orcid.org/0000-0003-0908-9964","observed_orcids":["https://orcid.org/0000-0003-0908-9964"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nhan L. Tran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5032029297","display_name":"Jeffrey A. Winkles","orcid":"https://orcid.org/0000-0002-3305-1424","observed_orcids":["https://orcid.org/0000-0002-3305-1424"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey A. Winkles","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fn14","display_name":"Fn14","score":0.9419999718666077},{"id":"https://openalex.org/keywords/fibroblast-growth-factor-inducible-14","display_name":"fibroblast growth factor-inducible 14","score":0.9440000057220459},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.8999999761581421},{"id":"https://openalex.org/keywords/heregulin-beta1","display_name":"heregulin beta1","score":0.9020000100135803},{"id":"https://openalex.org/keywords/her3","display_name":"HER3","score":0.7559999823570251},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7350000143051147},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.7910000085830688},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8109999895095825},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.8169999718666077},{"id":"https://openalex.org/keywords/her2-her3-heterodimer","display_name":"HER2/HER3 heterodimer","score":0.7919999957084656},{"id":"https://openalex.org/keywords/lapatinib","display_name":"lapatinib","score":0.8209999799728394},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.6620000004768372},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.796999990940094},{"id":"https://openalex.org/keywords/tnf-receptor-superfamily","display_name":"TNF receptor superfamily","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6940513849258423},{"id":"https://openalex.org/C2777329042","wikidata":"https://www.wikidata.org/wiki/Q420323","display_name":"Lapatinib","level":5,"score":0.5898758172988892},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.553106963634491},{"id":"https://openalex.org/C111798993","wikidata":"https://www.wikidata.org/wiki/Q21117471","display_name":"Fibroblast activation protein, alpha","level":3,"score":0.536564290523529},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5167178511619568},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45785626769065857},{"id":"https://openalex.org/C185323287","wikidata":"https://www.wikidata.org/wiki/Q59252204","display_name":"Neuregulin","level":3,"score":0.4548540413379669},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.44794464111328125},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4345775246620178},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4344950318336487},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.33207494020462036},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3098086714744568},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2666376829147339},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.26096197962760925},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.17590856552124023},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1541-7786.c.6539668","doi":"https://doi.org/10.1158/1541-7786.c.6539668","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1541-7786.c.6539668","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1541-7786.c.6539668.v1","doi":"https://doi.org/10.1158/1541-7786.c.6539668.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.6539668.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1541-7786.c.6539668","doi":"https://doi.org/10.1158/1541-7786.c.6539668","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1541-7786.c.6539668","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2331534532","https://openalex.org/W7098102749","https://openalex.org/W2031687784","https://openalex.org/W4392700653","https://openalex.org/W2135009937","https://openalex.org/W7202427937","https://openalex.org/W2313596856","https://openalex.org/W2074857430","https://openalex.org/W2325994600","https://openalex.org/W7067115435"],"abstract_inverted_index":{"Abstract":[0],"HER2":[1,24,28,80,108,132,171,179,186],"overexpression":[2,29],"occurs":[3],"in":[4,71,86,91,110,158,161,170],"15%":[5],"to":[6],"20%":[7],"of":[8,37,63,97,102,127,142,229],"all":[9],"breast":[10,43,74,98,111,231],"cancers":[11],"and":[12,19,41,47,81,149,155,187,206,212,235],"is":[13],"associated":[14],"with":[15,130,182],"increased":[16,135],"metastatic":[17],"potential":[18],"poor":[20],"patient":[21],"survival.":[22],"Abnormal":[23],"activation,":[25],"either":[26],"through":[27],"or":[30,124,184],"heregulin":[31],"(HRG):HER3":[32],"binding,":[33],"elicits":[34],"the":[35,64,153],"formation":[36],"potent":[38],"HER2\u2013HER3":[39],"heterodimers":[40],"drives":[42],"cancer":[44,112,232],"cell":[45,203,209,233],"growth":[46,57],"metastasis.":[48],"In":[49,100],"a":[50,61,131],"previous":[51],"study,":[52],"we":[53,105],"found":[54,121],"that":[55,79,89,122,195,221],"fibroblast":[56],"factor-inducible":[58],"14":[59],"(Fn14),":[60],"member":[62],"TNF":[65],"receptor":[66],"superfamily,":[67],"was":[68],"frequently":[69],"overexpressed":[70],"human":[72],"HER2+":[73],"tumors.":[75],"We":[76,120,192],"report":[77,194],"here":[78],"Fn14":[82,117,136,147,159,168,222],"are":[83],"also":[84,193],"coexpressed":[85],"mammary":[87],"tumors":[88],"develop":[90],"two":[92],"different":[93],"transgenic":[94],"mouse":[95],"models":[96],"cancer.":[99],"consideration":[101],"these":[103,218],"findings,":[104],"investigated":[106],"whether":[107],"activation":[109],"cells":[113,129,144,163,174,199],"could":[114,175],"directly":[115],"induce":[116],"gene":[118],"expression.":[119,151,216],"transient":[123],"stable":[125],"transfection":[126],"MCF7":[128,143,162,198],"expression":[133,160,169],"plasmid":[134],"protein":[137,150],"levels.":[138],"Also,":[139],"HRG1-\u03b21":[140],"treatment":[141],"transiently":[145],"induced":[146],"mRNA":[148],"Both":[152],"HER2-":[154],"HRG1-\u03b21\u2013induced":[156],"increase":[157],"as":[164,166],"well":[165],"basal":[167,202],"gene-amplified":[172],"AU565":[173],"be":[176,224],"reduced":[177,201,207],"by":[178],"kinase":[180],"inhibition":[181],"lapatinib":[183],"combined":[185],"HER3":[188],"depletion":[189],"using":[190],"siRNA.":[191],"Fn14-depleted,":[196],"HER2-overexpressing":[197],"have":[200],"migration":[204,234],"capacity":[205],"HRG1-\u03b21\u2013stimulated":[208],"migration,":[210],"invasion,":[211],"matrix":[213],"metalloproteinase":[214],"(MMP)-9":[215],"Together,":[217],"results":[219],"indicate":[220],"may":[223],"an":[225],"important":[226],"downstream":[227],"regulator":[228],"HER2/HER3\u2013driven":[230],"invasion.":[236],"Mol":[237],"Cancer":[238],"Res;":[239],"11(4);":[240],"393\u2013404.":[241],"\u00a92013":[242],"AACR.":[243]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-06T00:00:00"}