{"id":"https://openalex.org/W4362544404","doi":"https://doi.org/10.1158/1538-7445.am2023-4789","title":"Abstract 4789: Spin oscillating magnetic field sOMF of oncomagnetic device selectively kills glioma cancer cells by inducing oxidative stress and DNA damage","display_name":"Abstract 4789: Spin oscillating magnetic field sOMF of oncomagnetic device selectively kills glioma cancer cells by inducing oxidative stress and DNA damage","publication_year":2023,"publication_date":"2023-04-04","ids":{"openalex":"https://openalex.org/W4362544404","doi":"https://doi.org/10.1158/1538-7445.am2023-4789"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2023-4789","doi":"https://doi.org/10.1158/1538-7445.am2023-4789","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2023-4789","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082144268","display_name":"Shashank Hambarde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shashank Hambarde","raw_affiliation_strings":["1Houston Methodist Research Institute, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Houston Methodist Research Institute, Houston, TX","institution_ids":["https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028723719","display_name":"Arvind Pandey","orcid":"https://orcid.org/0000-0002-9942-5468","observed_orcids":["https://orcid.org/0000-0002-9942-5468"]},"institutions":[{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arvind Pandey","raw_affiliation_strings":["1Houston Methodist Research Institute, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Houston Methodist Research Institute, Houston, TX","institution_ids":["https://openalex.org/I4405286254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113572501","display_name":"David S. Baskin","orcid":"https://orcid.org/0000-0002-8076-382X","observed_orcids":["https://orcid.org/0000-0002-8076-382X"]},"institutions":[{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David S. Baskin","raw_affiliation_strings":["1Houston Methodist Research Institute, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Houston Methodist Research Institute, Houston, TX","institution_ids":["https://openalex.org/I4405286254"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057793256","display_name":"Santosh A. Helekar","orcid":"https://orcid.org/0000-0002-9264-0966","observed_orcids":["https://orcid.org/0000-0002-9264-0966"]},"institutions":[{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Santosh A. Helekar","raw_affiliation_strings":["1Houston Methodist Research Institute, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Houston Methodist Research Institute, Houston, TX","institution_ids":["https://openalex.org/I4405286254"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405286254"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"83","issue":"7_Supplement","first_page":"4789","last_page":"4789"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10874","display_name":"Electromagnetic Fields and Biological Effects","score":0.5946999788284302,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10874","display_name":"Electromagnetic Fields and Biological Effects","score":0.5946999788284302,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.37959998846054077,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12976","display_name":"Magnetic and Electromagnetic Effects","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9760000109672546},{"id":"https://openalex.org/keywords/diffuse-intrinsic-pontine-glioma","display_name":"diffuse intrinsic pontine glioma","score":0.9789999723434448},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7749999761581421},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.8500000238418579},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9419999718666077},{"id":"https://openalex.org/keywords/gamma-h2ax-foci","display_name":"\u03b3H2AX foci","score":0.8379999995231628},{"id":"https://openalex.org/keywords/53bp1-foci","display_name":"53BP1 foci","score":0.8539999723434448},{"id":"https://openalex.org/keywords/noninvasive-cancer-therapy","display_name":"noninvasive cancer therapy","score":0.6869999766349792},{"id":"https://openalex.org/keywords/clonogenic-survival","display_name":"clonogenic survival","score":0.6320000290870667},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.5210000276565552},{"id":"https://openalex.org/keywords/brain-tumor-treatment","display_name":"brain tumor therapy","score":0.39800000190734863},{"id":"https://openalex.org/keywords/recurrent-glioma","display_name":"recurrent glioma","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C117262875","wikidata":"https://www.wikidata.org/wiki/Q5135057","display_name":"Clonogenic assay","level":3,"score":0.6445627212524414},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6088159680366516},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6072256565093994},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.5668017268180847},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5150672793388367},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5150299072265625},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.47640979290008545},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.42120373249053955},{"id":"https://openalex.org/C2776231299","wikidata":"https://www.wikidata.org/wiki/Q245489","display_name":"Trolox","level":4,"score":0.4125620722770691},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.409856379032135},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.38090580701828003},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3644649386405945},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33083194494247437},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2657332420349121},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.13389965891838074},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07052871584892273},{"id":"https://openalex.org/C2993539680","wikidata":"https://www.wikidata.org/wiki/Q902552","display_name":"Antioxidant capacity","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2023-4789","doi":"https://doi.org/10.1158/1538-7445.am2023-4789","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2023-4789","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4309018004","https://openalex.org/W4408448142","https://openalex.org/W4416140270","https://openalex.org/W4404236827","https://openalex.org/W4362594001","https://openalex.org/W4221078373","https://openalex.org/W4297229187","https://openalex.org/W4388455335","https://openalex.org/W3197930904","https://openalex.org/W4308976881"],"abstract_inverted_index":{"Abstract":[0],"A":[1],"new":[2],"noninvasive":[3],"therapeutic":[4],"device":[5,13,45,62,296],"developed":[6,123],"in":[7,63,77,92,99,153,183,195,208],"our":[8],"laboratory":[9],"called":[10],"the":[11,43,48,51,68,139,158,238,258,313],"Oncomagnetic":[12],"provides":[14],"a":[15,119],"novel":[16],"approach":[17],"to":[18,129,157,225,252],"glioblastoma":[19],"(GBM)":[20],"treatment.":[21,85],"It":[22,36],"involves":[23],"repeated":[24],"stimulation":[25,121,246],"with":[26,87,118,261],"oscillating":[27,290],"magnetic":[28,291],"fields":[29],"(sOMF)":[30],"produced":[31,227],"by":[32,47,124,219,228,237,302],"spinning":[33],"permanent":[34],"magnets.":[35],"is":[37,268],"technologically":[38],"and":[39,56,109,141,168,173,186,214,306,325],"mechanistically":[40],"distinct":[41],"from":[42,271],"Optune\u00ae":[44,275],"approved":[46],"FDA":[49],"for":[50,131,203,274,316],"treatment":[52,117],"of":[53,60,70,84,161,171,211,265,294,312],"newly":[54],"diagnosed":[55],"recurrent":[57,72],"GBM.":[58],"Use":[59],"this":[61],"end-stage":[64],"GBM":[65,184,213],"patients":[66],"reversed":[67],"progression":[69],"their":[71,93],"tumor":[73,100],"causing":[74],">30%":[75],"reduction":[76,98],"its":[78],"contrast-enhanced":[79],"volume":[80],"within":[81],"4-6":[82],"weeks":[83],"Mice":[86],"implanted":[88],"mouse":[89],"glioma":[90,190,299],"cells":[91,155,185,192,301],"brains":[94],"also":[95],"showed":[96,176],"marked":[97],"size,":[101],"increased":[102,147],"survival":[103,222],"(p<":[104],"0.05,":[105],"n":[106],"=":[107],"10)":[108],"higher":[110],"DNA":[111,181,307],"damage":[112,182],"(\u03b3-H2AX":[113],"foci)":[114],"after":[115],"sOMF":[116,130,145,178,201,245,293],"whole-body":[120],"method":[122],"us.":[125],"Normal":[126],"mice":[127],"exposed":[128],"4":[132],"months":[133],"had":[134],"no":[135],"adverse":[136],"effects":[137],"on":[138],"brain":[140],"other":[142],"organs.":[143],"In-vitro,":[144],"markedly":[146],"reactive":[148],"oxygen":[149],"species":[150],"(ROS)":[151],"levels":[152],"cancer":[154,300],"leading":[156],"selective":[159],"death":[160],"these":[162],"cells,":[163],"while":[164],"sparing":[165],"normal":[166,196],"neurons":[167],"astrocytes.":[169],"Detection":[170],"\u03b3-H2AX":[172],"53BP1":[174],"foci":[175],"that":[177,226,244,267,272],"caused":[179],"significant":[180],"diffuse":[187],"intrinsic":[188],"pontine":[189],"(DIPG)":[191],"but":[193],"not":[194],"astroglial":[197],"SVGp12":[198],"cells.":[199],"Furthermore,":[200],"exposure":[202],"just":[204],"2":[205,229],"h":[206],"resulted":[207],">40%":[209],"loss":[210,234],"surviving":[212],"DIPG":[215],"cell":[216,221],"colonies":[217],"detected":[218],"clonogenic":[220],"assay,":[223],"similar":[224],"Gy":[230],"radiation":[231,255],"dose.":[232],"This":[233],"was":[235],"rescued":[236],"antioxidant":[239],"Trolox.":[240],"These":[241],"results":[242],"indicate":[243],"has":[247],"high":[248],"anticancer":[249],"potency":[250],"comparable":[251],"low":[253],"dose":[254],"therapy":[256],"at":[257],"cellular":[259],"level":[260],"an":[262],"underlying":[263],"mechanism":[264],"action":[266],"substantially":[269],"different":[270],"proposed":[273],"TTF.":[276],"Citation":[277],"Format:":[278],"Shashank":[279],"Hambarde,":[280],"Arvind":[281],"Pandey,":[282],"David":[283],"S.":[284],"Baskin,":[285],"Santosh":[286],"A.":[287],"Helekar.":[288],"Spin":[289],"field":[292],"oncomagnetic":[295],"selectively":[297],"kills":[298],"inducing":[303],"oxidative":[304],"stress":[305],"damage.":[308],"[abstract].":[309],"In:":[310],"Proceedings":[311],"American":[314],"Association":[315],"Cancer":[317,336],"Research":[318],"Annual":[319],"Meeting":[320],"2023;":[321],"Part":[322],"1":[323],"(Regular":[324],"Invited":[326],"Abstracts);":[327],"2023":[328],"Apr":[329],"14-19;":[330],"Orlando,":[331],"FL.":[332],"Philadelphia":[333],"(PA):":[334],"AACR;":[335],"Res":[337],"2023;83(7_Suppl):Abstract":[338],"nr":[339],"4789.":[340]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-06T00:00:00"}
