{"id":"https://openalex.org/W4362544239","doi":"https://doi.org/10.1158/1538-7445.am2023-3709","title":"Abstract 3709: Hyperglycemia induces metabolic reprogramming and promotes epithelial-mesenchymal transitions in pancreatic cancer: an in vitro and in vivo experiment","display_name":"Abstract 3709: Hyperglycemia induces metabolic reprogramming and promotes epithelial-mesenchymal transitions in pancreatic cancer: an in vitro and in vivo experiment","publication_year":2023,"publication_date":"2023-04-04","ids":{"openalex":"https://openalex.org/W4362544239","doi":"https://doi.org/10.1158/1538-7445.am2023-3709"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2023-3709","doi":"https://doi.org/10.1158/1538-7445.am2023-3709","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2023-3709","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100686089","display_name":"Zhao Liu","orcid":"https://orcid.org/0000-0003-2058-1562","observed_orcids":["https://orcid.org/0000-0003-2058-1562"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Zhao Liu","raw_affiliation_strings":["1Kumamoto Univ Graduate School of Medical Sci, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Kumamoto Univ Graduate School of Medical Sci, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017859885","display_name":"Hiromitsu Hayashi","orcid":"https://orcid.org/0000-0002-1832-4287","observed_orcids":["https://orcid.org/0000-0002-1832-4287"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromitsu Hayashi","raw_affiliation_strings":["1Kumamoto Univ Graduate School of Medical Sci, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Kumamoto Univ Graduate School of Medical Sci, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102835211","display_name":"Kazuki Matsumura","orcid":"https://orcid.org/0000-0002-6204-9147","observed_orcids":["https://orcid.org/0000-0002-6204-9147"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuki Matsumura","raw_affiliation_strings":["1Kumamoto Univ Graduate School of Medical Sci, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Kumamoto Univ Graduate School of Medical Sci, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047178433","display_name":"Yoko Ogata","orcid":"https://orcid.org/0009-0009-0271-9557","observed_orcids":["https://orcid.org/0009-0009-0271-9557"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoko Ogata","raw_affiliation_strings":["1Kumamoto Univ Graduate School of Medical Sci, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Kumamoto Univ Graduate School of Medical Sci, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031936902","display_name":"Hiroki Sato","orcid":"https://orcid.org/0000-0002-3346-5053","observed_orcids":["https://orcid.org/0000-0002-3346-5053"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Sato","raw_affiliation_strings":["1Kumamoto Univ Graduate School of Medical Sci, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Kumamoto Univ Graduate School of Medical Sci, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025411980","display_name":"Yuta Shiraishi","orcid":"https://orcid.org/0009-0008-4430-4977","observed_orcids":["https://orcid.org/0009-0008-4430-4977"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuta Shiraishi","raw_affiliation_strings":["1Kumamoto Univ Graduate School of Medical Sci, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Kumamoto Univ Graduate School of Medical Sci, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102340560","display_name":"Norio Uemura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norio Uemura","raw_affiliation_strings":["1Kumamoto Univ Graduate School of Medical Sci, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Kumamoto Univ Graduate School of Medical Sci, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089439603","display_name":"Tatsunori Miyata","orcid":"https://orcid.org/0000-0003-4749-4741","observed_orcids":["https://orcid.org/0000-0003-4749-4741"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsunori Miyata","raw_affiliation_strings":["1Kumamoto Univ Graduate School of Medical Sci, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Kumamoto Univ Graduate School of Medical Sci, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102264371","display_name":"Takaaki Higashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takaaki Higashi","raw_affiliation_strings":["1Kumamoto Univ Graduate School of Medical Sci, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Kumamoto Univ Graduate School of Medical Sci, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056749064","display_name":"Shigeki Nakagawa","orcid":"https://orcid.org/0000-0003-3994-4028","observed_orcids":["https://orcid.org/0000-0003-3994-4028"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeki Nakagawa","raw_affiliation_strings":["1Kumamoto Univ Graduate School of Medical Sci, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Kumamoto Univ Graduate School of Medical Sci, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035573322","display_name":"Kosuke Mima","orcid":"https://orcid.org/0000-0002-4385-4984","observed_orcids":["https://orcid.org/0000-0002-4385-4984"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kosuke Mima","raw_affiliation_strings":["1Kumamoto Univ Graduate School of Medical Sci, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Kumamoto Univ Graduate School of Medical Sci, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065485846","display_name":"Katsunori Imai","orcid":"https://orcid.org/0000-0003-0549-1825","observed_orcids":["https://orcid.org/0000-0003-0549-1825"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsunori Imai","raw_affiliation_strings":["1Kumamoto Univ Graduate School of Medical Sci, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Kumamoto Univ Graduate School of Medical Sci, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113523976","display_name":"Hideo Baba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideo Baba","raw_affiliation_strings":["1Kumamoto Univ Graduate School of Medical Sci, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Kumamoto Univ Graduate School of Medical Sci, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I96036126"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"83","issue":"7_Supplement","first_page":"3709","last_page":"3709"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.7612000107765198,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.7612000107765198,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.1168999969959259,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.03440000116825104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8989999890327454},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":1.0},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.8809999823570251},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9620000123977661},{"id":"https://openalex.org/keywords/yap-taz","display_name":"YAP/TAZ","score":0.8370000123977661},{"id":"https://openalex.org/keywords/hedgehog-signaling","display_name":"Hedgehog signaling","score":0.9139999747276306},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.7419999837875366},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cancer-associated-fibroblasts","display_name":"cancer-associated fibroblasts","score":0.9369999766349792},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7870000004768372},{"id":"https://openalex.org/keywords/warburg-effect","display_name":"Warburg effect","score":0.8080000281333923},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.7760000228881836},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7820000052452087},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8209999799728394}],"concepts":[{"id":"https://openalex.org/C2779933373","wikidata":"https://www.wikidata.org/wiki/Q14886430","display_name":"GLI1","level":4,"score":0.7358611822128296},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.726503849029541},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.7247361540794373},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6345342397689819},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5346882343292236},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.5154691338539124},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.473191499710083},{"id":"https://openalex.org/C52124034","wikidata":"https://www.wikidata.org/wiki/Q557179","display_name":"Stroma","level":3,"score":0.4472252428531647},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.4421460032463074},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4313219487667084},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4146724343299866},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.36546069383621216},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34527236223220825},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3273797035217285},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.306021511554718},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26228731870651245},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2404506802558899},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.14493432641029358},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1368297040462494},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.11918440461158752},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.10252776741981506},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07516565918922424},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2023-3709","doi":"https://doi.org/10.1158/1538-7445.am2023-3709","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2023-3709","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4312019962","https://openalex.org/W4364322878","https://openalex.org/W2463277323","https://openalex.org/W2774679832","https://openalex.org/W3160286385","https://openalex.org/W2332007133","https://openalex.org/W2999726307","https://openalex.org/W3127859676","https://openalex.org/W2898650303","https://openalex.org/W4388140867"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Pancreatic":[2],"cancer":[3],"is":[4,18,135],"a":[5,19,86,183,216,252],"serious":[6],"life-threatening":[7],"disease":[8],"due":[9],"to":[10],"its":[11],"highly":[12,239],"invasive":[13,240],"and":[14,51,74,100,115,144,158,182,193,219,241,291,301,321],"metastatic":[15,242],"potential.":[16],"Hyperglycemia":[17,78,146,211,229,287],"well-known":[20],"initial":[21,232],"symptom":[22,233],"in":[23,32,56,67,72,75,104,164,191,194,206,227,256,295,299,302],"patients":[24],"with":[25,122,175,202],"pancreatic":[26,296],"ductal":[27],"adenocarcinoma":[28],"(PDAC).":[29],"Metabolic":[30],"reprogramming":[31,84,214,290],"cancer,":[33],"described":[34],"as":[35,230],"the":[36,49,223,236,309],"Warburg":[37],"effect,":[38],"can":[39],"induce":[40,212],"epithelial-mesenchymal":[41,293],"transition":[42],"(EMT).":[43],"In":[44,106],"this":[45],"study,":[46],"we":[47],"elucidate":[48],"biological":[50],"clinical":[52],"impact":[53,61],"of":[54,62,149,169,238,308],"hyperglycemia":[55,63,108],"PDAC":[57,68,117,134,208,257],"progression.":[58],"Methods:":[59],"Biological":[60],"on":[64],"malignant":[65],"behavior":[66],"was":[69,199],"examined":[70],"by":[71,81,97,111,137,160,244],"vitro":[73,192,300],"vivoexperiment.":[76],"Results:":[77],"promoted":[79],"EMT":[80,221],"inducing":[82,245],"metabolic":[83,213,289],"into":[85,119,215],"glycolytic":[87,217],"phenotype":[88,218],"via":[89,222],"yes-associated":[90],"protein":[91],"(YAP)/PDZ-binding":[92],"motif":[93],"(TAZ)":[94],"overexpression,":[95,247],"accompanied":[96],"GLUT1":[98],"overexpression":[99,198],"enhanced":[101,109],"phosphorylation":[102],"Akt":[103],"PDAC.":[105,228],"addition,":[107],"chemoresistance":[110],"upregulating":[112],"ABCB1":[113],"expression,":[114],"triggered":[116],"switch":[118],"pure-basal-like":[120],"subtype":[121],"activated":[123],"Hedgehog":[124],"pathway":[125],"(GLI1":[126],"high,":[127],"GATA6":[128],"low":[129],"expression)":[130],"through":[131],"YAP/TAZ":[132,162,176,197,246,249],"overexpression.":[133],"characterized":[136],"abundant":[138],"stroma":[139],"that":[140],"harbors":[141],"tumor-promoting":[142],"properties":[143],"chemoresistance.":[145],"promotes":[147,292],"production":[148],"collagen":[150],"fiber-related":[151],"proteins":[152],"(fibronectin,":[153],"fibroblast":[154],"activation":[155],"protein,":[156],"COL1A1,":[157],"COL11A1)":[159],"stimulating":[161],"expression":[163],"cancer-associated":[165],"fibroblasts":[166],"(CAFs).":[167],"Knockdown":[168],"YAP":[170],"and/or":[171],"TAZ":[172],"or":[173],"treatment":[174],"inhibitor":[177],"(K975)":[178],"abolished":[179],"EMT,":[180],"chemoresistance,":[181],"favorable":[184],"tumor":[185],"microenvironment":[186],"even":[187],"under":[188],"hyperglycemic":[189],"conditions":[190],"vivo.":[195],"Indeed,":[196],"significantly":[200],"associated":[201],"worse":[203],"prognostic":[204],"outcomes":[205],"human":[207],"patients.":[209,258],"Conclusion:":[210],"promote":[220],"YAP/TAZ-Hedgehog":[224],"signaling":[225],"axis":[226],"an":[231,298],"may":[234],"be":[235,251],"cause":[237],"potential":[243],"while":[248],"could":[250],"novel":[253],"therapeutic":[254],"target":[255],"Citation":[259],"Format:":[260],"Zhao":[261],"Liu,":[262],"Hiromitsu":[263],"Hayashi,":[264],"Kazuki":[265],"Matsumura,":[266],"Yoko":[267],"Ogata,":[268],"Hiroki":[269],"Sato,":[270],"Yuta":[271],"Shiraishi,":[272],"Norio":[273],"Uemura,":[274],"Tatsunori":[275],"Miyata,":[276],"Takaaki":[277],"Higashi,":[278],"Shigeki":[279],"Nakagawa,":[280],"Kosuke":[281],"Mima,":[282],"Katsunori":[283],"Imai,":[284],"Hideo":[285],"Baba.":[286],"induces":[288],"transitions":[294],"cancer:":[297],"vivo":[303],"experiment.":[304],"[abstract].":[305],"In:":[306],"Proceedings":[307],"American":[310],"Association":[311],"for":[312],"Cancer":[313,332],"Research":[314],"Annual":[315],"Meeting":[316],"2023;":[317],"Part":[318],"1":[319],"(Regular":[320],"Invited":[322],"Abstracts);":[323],"2023":[324],"Apr":[325],"14-19;":[326],"Orlando,":[327],"FL.":[328],"Philadelphia":[329],"(PA):":[330],"AACR;":[331],"Res":[333],"2023;83(7_Suppl):Abstract":[334],"nr":[335],"3709.":[336]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2023-04-06T00:00:00"}
