{"id":"https://openalex.org/W4362544167","doi":"https://doi.org/10.1158/1538-7445.am2023-3702","title":"Abstract 3702: Serine promotes aggressive phenotype in renal cancer","display_name":"Abstract 3702: Serine promotes aggressive phenotype in renal cancer","publication_year":2023,"publication_date":"2023-04-04","ids":{"openalex":"https://openalex.org/W4362544167","doi":"https://doi.org/10.1158/1538-7445.am2023-3702"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2023-3702","doi":"https://doi.org/10.1158/1538-7445.am2023-3702","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2023-3702","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105123714","display_name":"Suman Karki","orcid":"https://orcid.org/0000-0003-4393-4041","observed_orcids":["https://orcid.org/0000-0003-4393-4041"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suman Karki","raw_affiliation_strings":["1University of Alabama at Birmingham, Birmingham, AL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Alabama at Birmingham, Birmingham, AL;","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017259077","display_name":"Anirban Kundu","orcid":"https://orcid.org/0000-0003-0621-9989","observed_orcids":["https://orcid.org/0000-0003-0621-9989"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anirban Kundu","raw_affiliation_strings":["1University of Alabama at Birmingham, Birmingham, AL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Alabama at Birmingham, Birmingham, AL;","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068776649","display_name":"Garrett J. Brinkley","orcid":"https://orcid.org/0000-0003-2622-3416","observed_orcids":["https://orcid.org/0000-0003-2622-3416"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Garret Brinkley","raw_affiliation_strings":["2Tulane University, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Tulane University, New Orleans, LA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049169540","display_name":"Hyeyoung Nam","orcid":"https://orcid.org/0000-0002-9964-728X","observed_orcids":["https://orcid.org/0000-0002-9964-728X"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hyeyoung Nam","raw_affiliation_strings":["1University of Alabama at Birmingham, Birmingham, AL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Alabama at Birmingham, Birmingham, AL;","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057499082","display_name":"Kayla F. Goliwas","orcid":"https://orcid.org/0000-0002-6930-6636","observed_orcids":["https://orcid.org/0000-0002-6930-6636"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kayla Goliwas","raw_affiliation_strings":["1University of Alabama at Birmingham, Birmingham, AL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Alabama at Birmingham, Birmingham, AL;","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005357486","display_name":"Jessy S. Deshane","orcid":"https://orcid.org/0000-0002-6761-5662","observed_orcids":["https://orcid.org/0000-0002-6761-5662"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessy Deshane","raw_affiliation_strings":["1University of Alabama at Birmingham, Birmingham, AL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Alabama at Birmingham, Birmingham, AL;","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086808449","display_name":"Sunil Sudarshan","orcid":"https://orcid.org/0000-0001-7257-6277","observed_orcids":["https://orcid.org/0000-0001-7257-6277"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunil Sudarshan","raw_affiliation_strings":["1University of Alabama at Birmingham, Birmingham, AL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Alabama at Birmingham, Birmingham, AL;","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"83","issue":"7_Supplement","first_page":"3702","last_page":"3702"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9023000001907349,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9023000001907349,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.040300000458955765,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serine","display_name":"serine","score":0.9739999771118164},{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.8410000205039978},{"id":"https://openalex.org/keywords/non-essential-amino-acids","display_name":"non-essential amino acids","score":0.9470000267028809},{"id":"https://openalex.org/keywords/glutamine","display_name":"glutamine","score":0.984000027179718},{"id":"https://openalex.org/keywords/tumor-cell-migration","display_name":"tumor cell migration","score":0.6520000100135803},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8619999885559082},{"id":"https://openalex.org/keywords/snail1","display_name":"SNAI1","score":0.8339999914169312},{"id":"https://openalex.org/keywords/integrated-stress-response","display_name":"integrated stress response","score":0.8899999856948853},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9010000228881836},{"id":"https://openalex.org/keywords/translational-reprogramming","display_name":"translational reprogramming","score":0.949999988079071},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7960000038146973}],"concepts":[{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6465676426887512},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5666719675064087},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5110656023025513},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5065726041793823},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.49718573689460754},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.4850274920463562},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.4499012231826782},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.4483918249607086},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.43675458431243896},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4269421398639679},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4133874177932739},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3103950619697571},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2799226939678192},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26406580209732056},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2321547567844391},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17267534136772156},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.16788536310195923},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.07928448915481567}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2023-3702","doi":"https://doi.org/10.1158/1538-7445.am2023-3702","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2023-3702","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4385837053","https://openalex.org/W4385837061","https://openalex.org/W4405514725","https://openalex.org/W3201403209","https://openalex.org/W4293770053","https://openalex.org/W4415985297","https://openalex.org/W4411078142","https://openalex.org/W4385837109","https://openalex.org/W4393218271","https://openalex.org/W2914788991"],"abstract_inverted_index":{"Abstract":[0],"Tumor":[1],"cells":[2,22],"are":[3,23,93],"known":[4],"to":[5,11,97,158,172,197],"have":[6],"increased":[7],"demand":[8],"for":[9,111,184,236],"nutrients":[10,19],"support":[12,98],"proliferation.":[13],"Among":[14],"the":[15,29,54,75,81,104,112,115,124,132,140,151,173,233],"most":[16],"highly":[17],"utilized":[18],"by":[20,200],"tumor":[21,35,190],"nonessential":[24],"amino":[25],"acids":[26],"(NEAAs).":[27],"While":[28],"role":[30,40,76,125],"of":[31,57,77,83,106,114,126,134,144,160,232],"NEAAs":[32,78,108,129],"in":[33,41,79,101,130,147,187,226],"supporting":[34,42,131,188],"growth":[36],"is":[37,50,67,109],"well-established,":[38],"their":[39],"aggressive":[43,99,165,189,224],"phenotypes":[44,100,191],"such":[45,61],"as":[46,62],"migration":[47,82],"and":[48,91,95,163,192,245],"invasion":[49],"poorly":[51],"understood.":[52],"Yet,":[53],"major":[55],"cause":[56],"morbidity":[58],"from":[59],"malignancies":[60],"renal":[63,227],"cell":[64],"carcinoma":[65],"(RCC)":[66],"metastasis.":[68],"Through":[69],"an":[70],"unbiased":[71],"approach,":[72],"we":[73],"assayed":[74],"promoting":[80],"RCC":[84],"cells.":[85],"We":[86],"demonstrate":[87],"that":[88,138,156],"exogenous":[89],"serine":[90],"glutamine":[92],"essential":[94],"sufficient":[96],"RCC.":[102],"Moreover,":[103],"availability":[105,141,203],"both":[107],"critical":[110],"expression":[113,162],"proinvasive":[116],"transcription":[117],"factor":[118],"SNAIL.":[119],"Our":[120,167],"data":[121],"converge":[122],"on":[123],"these":[127],"two":[128],"translation":[133],"this":[135],"factor.":[136],"Perturbations":[137],"limit":[139],"and/or":[142,204],"synthesis":[143],"either":[145],"result":[146],"translational":[148],"reprogramming":[149],"through":[150],"integrated":[152],"stress":[153],"response":[154],"(ISR)":[155],"leads":[157],"loss":[159],"SNAIL1":[161],"attenuates":[164],"phenotypes.":[166],"findings":[168],"associate":[169],"nutrient":[170],"status":[171],"ISR":[174],"including":[175],"ER":[176],"stress.":[177],"Collectively,":[178],"our":[179],"study":[180],"highlights":[181],"new":[182],"insights":[183],"NEAA":[185,202],"metabolism":[186],"could":[193],"reveal":[194],"novel":[195],"approaches":[196],"mitigate":[198],"metastasis":[199],"targeting":[201],"utilization.":[205],"Citation":[206],"Format:":[207],"Suman":[208],"Karki,":[209],"Anirban":[210],"Kundu,":[211],"Garret":[212],"Brinkley,":[213],"Hyeyoung":[214],"Nam,":[215],"Kayla":[216],"Goliwas,":[217],"Jessy":[218],"Deshane,":[219],"Sunil":[220],"Sudarshan.":[221],"Serine":[222],"promotes":[223],"phenotype":[225],"cancer.":[228],"[abstract].":[229],"In:":[230],"Proceedings":[231],"American":[234],"Association":[235],"Cancer":[237,256],"Research":[238],"Annual":[239],"Meeting":[240],"2023;":[241],"Part":[242],"1":[243],"(Regular":[244],"Invited":[246],"Abstracts);":[247],"2023":[248],"Apr":[249],"14-19;":[250],"Orlando,":[251],"FL.":[252],"Philadelphia":[253],"(PA):":[254],"AACR;":[255],"Res":[257],"2023;83(7_Suppl):Abstract":[258],"nr":[259],"3702.":[260]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2023-04-06T00:00:00"}
