{"id":"https://openalex.org/W4362542002","doi":"https://doi.org/10.1158/1535-7163.c.6538162","title":"Data from ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity","display_name":"Data from ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362542002","doi":"https://doi.org/10.1158/1535-7163.c.6538162"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.c.6538162","doi":"https://doi.org/10.1158/1535-7163.c.6538162","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6538162","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1535-7163.c.6538162","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031503332","display_name":"Tim H. Holmstr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tim H. Holmstr\u00f6m","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110238605","display_name":"Anu\u2010Maarit Moilanen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anu-Maarit Moilanen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113636312","display_name":"Tarja Ikonen","orcid":"https://orcid.org/0000-0002-2018-6370","observed_orcids":["https://orcid.org/0000-0002-2018-6370"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tarja Ikonen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081474353","display_name":"Mari L. Bj\u00f6rkman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mari L. Bj\u00f6rkman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021313660","display_name":"Tero Linnanen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tero Linnanen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075892383","display_name":"Gerd Wohlfahrt","orcid":"https://orcid.org/0000-0003-0530-2000","observed_orcids":["https://orcid.org/0000-0003-0530-2000"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerd Wohlfahrt","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0530-2000","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Stefan Karlsson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefan Karlsson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082795809","display_name":"Riikka Oksala","orcid":"https://orcid.org/0000-0001-6256-562X","observed_orcids":["https://orcid.org/0000-0001-6256-562X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Riikka Oksala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051890127","display_name":"Timo Korjamo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timo Korjamo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039885523","display_name":"Susanta Samajdar","orcid":"https://orcid.org/0000-0002-3508-4801","observed_orcids":["https://orcid.org/0000-0002-3508-4801"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susanta Samajdar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Srinivasan Rajagopalan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Srinivasan Rajagopalan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024438197","display_name":"Shekar Chelur","orcid":"https://orcid.org/0000-0001-7017-4063","observed_orcids":["https://orcid.org/0000-0001-7017-4063"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shekar Chelur","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104270009","display_name":"Kishore Narayanan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kishore Narayanan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085141768","display_name":"Raghuveer K. Ramachandra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raghuveer K. Ramachandra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013156445","display_name":"Jiju Mani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiju Mani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Rashmi Nair","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rashmi Nair","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068629547","display_name":"Nagaraj M. Gowda","orcid":"https://orcid.org/0000-0002-1635-8272","observed_orcids":["https://orcid.org/0000-0002-1635-8272"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nagaraj Gowda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112906148","display_name":"Thomas Anthony","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Anthony","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012371044","display_name":"Samiulla Dhodheri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samiulla Dhodheri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066740338","display_name":"Subhendu Mukherjee","orcid":"https://orcid.org/0000-0002-4851-4428","observed_orcids":["https://orcid.org/0000-0002-4851-4428"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Subhendu Mukherjee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040205341","display_name":"Ravi K. Ujjinamatada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ravi K. Ujjinamatada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076134247","display_name":"Srinivas Nanduri","orcid":"https://orcid.org/0000-0002-6671-2022","observed_orcids":["https://orcid.org/0000-0002-6671-2022"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nanduri Srinivas","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6671-2022","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065784113","display_name":"Murali Ramachandra","orcid":"https://orcid.org/0000-0003-4039-1491","observed_orcids":["https://orcid.org/0000-0003-4039-1491"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Murali Ramachandra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5016359992","display_name":"Pekka J. Kallio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pekka J. Kallio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.6304000020027161,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.6304000020027161,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.36820000410079956,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fgfr-inhibitors","display_name":"FGFR inhibitors","score":0.7839999794960022},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.9580000042915344},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.8920000195503235},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8119999766349792},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.6840000152587891},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9409999847412109},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9869999885559082},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8029999732971191},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.7080000042915344},{"id":"https://openalex.org/keywords/kinase-inhibitor-selectivity","display_name":"kinase selectivity","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C2779193416","wikidata":"https://www.wikidata.org/wiki/Q3240226","display_name":"Syngenic","level":3,"score":0.8400291204452515},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6979785561561584},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5860726833343506},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5842964053153992},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5670403242111206},{"id":"https://openalex.org/C2776056115","wikidata":"https://www.wikidata.org/wiki/Q574834","display_name":"Angiogenesis inhibitor","level":3,"score":0.4691399931907654},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4603436291217804},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.437975138425827},{"id":"https://openalex.org/C82867764","wikidata":"https://www.wikidata.org/wiki/Q24780051","display_name":"Fibroblast growth factor receptor","level":4,"score":0.42482346296310425},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.3928992748260498},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3552664518356323},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3456721603870392},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3380517363548279},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16368982195854187},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1535-7163.c.6538162","doi":"https://doi.org/10.1158/1535-7163.c.6538162","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6538162","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1535-7163.c.6538162.v1","doi":"https://doi.org/10.1158/1535-7163.c.6538162.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6538162.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.c.6538162","doi":"https://doi.org/10.1158/1535-7163.c.6538162","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6538162","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2897182820","https://openalex.org/W1419085830","https://openalex.org/W1976715358","https://openalex.org/W4411576066","https://openalex.org/W2314425995","https://openalex.org/W4392726030","https://openalex.org/W2256390731","https://openalex.org/W2161730969","https://openalex.org/W2142702787","https://openalex.org/W2025170362"],"abstract_inverted_index":{"Abstract":[0],"Alterations":[1],"in":[2,17,65,100,108,129,143,149,165,177,187,196,236],"the":[3,7,12,77,101,178,188,197],"gene":[4],"encoding":[5],"for":[6,226],"FGFR":[8,29,40,60,78,90,228,238],"and":[9,24,30,37,73,79,91,96,148,204,210,213,229,233,239],"upregulation":[10],"of":[11,39,52,76,199,216],"VEGFR":[13,31,55,80,92,230],"are":[14,63],"found":[15],"often":[16],"cancer,":[18],"which":[19],"correlate":[20],"with":[21,97,122,184],"disease":[22],"progression":[23],"unfavorable":[25],"survival.":[26],"In":[27,82,111,136,158,220],"addition,":[28,159],"signaling":[32,41],"synergistically":[33],"promote":[34],"tumor":[35,163,189],"angiogenesis,":[36],"activation":[38,215],"has":[42],"been":[43],"described":[44],"as":[45,125,191],"functional":[46],"compensatory":[47],"angiogenic":[48,151],"signal":[49],"following":[50],"development":[51],"resistance":[53],"to":[54],"inhibition.":[56],"Several":[57],"selective":[58],"small-molecule":[59],"kinase":[61,231],"inhibitors":[62],"currently":[64],"clinical":[66],"development.":[67],"ODM-203":[68,88,114,138,160,222],"is":[69],"a":[70,166],"novel,":[71],"selective,":[72],"equipotent":[74,224],"inhibitor":[75],"families.":[81],"this":[83],"report":[84],"we":[85],"show":[86],"that":[87],"inhibits":[89,115,127,161],"family":[93],"kinases":[94],"selectively":[95],"equal":[98],"potency":[99,124],"low":[102],"nanomolar":[103],"range":[104],"(IC50":[105,119,133],"6\u201335":[106],"nmol/L)":[107,121],"biochemical":[109],"assays.":[110],"cellular":[112],"assays,":[113],"VEGFR-induced":[116],"tube":[117],"formation":[118],"33":[120],"similar":[123,155],"it":[126],"proliferation":[128],"FGFR-dependent":[130,145],"cell":[131],"lines":[132],"50\u2013150":[134],"nmol/L).":[135],"vivo,":[137],"shows":[139,223],"strong":[140],"antitumor":[141,175,234],"activity":[142,176,225,235],"both":[144,227,237],"xenograft":[146,152],"models":[147],"an":[150],"model":[153,181],"at":[154],"well-tolerated":[156],"doses.":[157],"metastatic":[162],"growth":[164],"highly":[167],"angiogenesis-dependent":[168],"kidney":[169],"capsule":[170],"syngenic":[171,180],"model.":[172],"Interestingly,":[173],"potent":[174],"subcutaneous":[179],"correlated":[182],"well":[183],"immune":[185,200],"modulation":[186],"microenvironment":[190],"indicated":[192],"by":[193],"marked":[194],"decrease":[195],"expression":[198],"check":[201],"points":[202],"PD-1":[203],"PD-L1":[205],"on":[206],"CD8":[207,217],"T":[208,218],"cells":[209],"NK":[211],"cells,":[212],"increased":[214],"cells.":[219],"summary,":[221],"families":[232],"angigogenesis":[240],"models.":[241]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-04-06T00:00:00"}