{"id":"https://openalex.org/W4362541886","doi":"https://doi.org/10.1158/1541-7786.c.6541135","title":"Data from Novel Regulation of Integrin Trafficking by Rab11-FIP5 in Aggressive Prostate Cancer","display_name":"Data from Novel Regulation of Integrin Trafficking by Rab11-FIP5 in Aggressive Prostate Cancer","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362541886","doi":"https://doi.org/10.1158/1541-7786.c.6541135"},"language":"en","primary_location":{"id":"doi:10.1158/1541-7786.c.6541135","doi":"https://doi.org/10.1158/1541-7786.c.6541135","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.6541135","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1541-7786.c.6541135","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Lipsa Das","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lipsa Das","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000722084","display_name":"Jaime M.C. Gard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaime M.C. Gard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057794718","display_name":"Rytis Prekeris","orcid":"https://orcid.org/0000-0003-3393-1963","observed_orcids":["https://orcid.org/0000-0003-3393-1963"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rytis Prekeris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080916822","display_name":"Raymond B. Nagle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raymond B. Nagle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014047283","display_name":"Colm M. Morrissey","orcid":"https://orcid.org/0000-0003-1906-5333","observed_orcids":["https://orcid.org/0000-0003-1906-5333"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Colm Morrissey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060130342","display_name":"Beatrice S. Knudsen","orcid":"https://orcid.org/0000-0002-7589-7591","observed_orcids":["https://orcid.org/0000-0002-7589-7591"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Beatrice S. Knudsen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7589-7591","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039815523","display_name":"Cindy K. Miranti","orcid":"https://orcid.org/0000-0003-0668-6106","observed_orcids":["https://orcid.org/0000-0003-0668-6106"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cindy K. Miranti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5080838230","display_name":"Anne E. Cress","orcid":"https://orcid.org/0000-0001-6194-0061","observed_orcids":["https://orcid.org/0000-0001-6194-0061"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anne E. Cress","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6194-0061","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.5019999742507935,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.5019999742507935,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.49559998512268066,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/integrin-trafficking","display_name":"integrin trafficking","score":0.8370000123977661},{"id":"https://openalex.org/keywords/integrin-alpha6beta1","display_name":"alpha6beta1 integrin","score":0.972000002861023},{"id":"https://openalex.org/keywords/integrin-alpha3beta1","display_name":"alpha3beta1 integrin","score":0.9779999852180481},{"id":"https://openalex.org/keywords/laminin-binding-integrins","display_name":"laminin-binding integrins","score":0.9359999895095825},{"id":"https://openalex.org/keywords/endocytic-recycling","display_name":"endocytic recycling","score":0.9179999828338623},{"id":"https://openalex.org/keywords/prostate-cancer-metastasis","display_name":"prostate cancer metastasis","score":0.843999981880188},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cell-cell-contact","display_name":"cell-cell contact","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.6349611878395081},{"id":"https://openalex.org/C2779814568","wikidata":"https://www.wikidata.org/wiki/Q58345","display_name":"Laminin","level":3,"score":0.6336699724197388},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6076972484588623},{"id":"https://openalex.org/C79747257","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytic cycle","level":4,"score":0.5607845187187195},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.474787175655365},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4693865478038788},{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.44553542137145996},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.435441255569458},{"id":"https://openalex.org/C197462201","wikidata":"https://www.wikidata.org/wiki/Q2476074","display_name":"Cell surface receptor","level":3,"score":0.4216139316558838},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.41667473316192627},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41666731238365173},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39835020899772644},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.393058717250824},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3100053071975708},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.24078387022018433},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21270659565925598},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18877309560775757},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1656455397605896}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1541-7786.c.6541135","doi":"https://doi.org/10.1158/1541-7786.c.6541135","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.6541135","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1541-7786.c.6541135.v1","doi":"https://doi.org/10.1158/1541-7786.c.6541135.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1541-7786.c.6541135.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1541-7786.c.6541135","doi":"https://doi.org/10.1158/1541-7786.c.6541135","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.6541135","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2804792246","https://openalex.org/W2761006450","https://openalex.org/W4362529304","https://openalex.org/W4362529138","https://openalex.org/W2609235244","https://openalex.org/W4362486267","https://openalex.org/W4362529307","https://openalex.org/W1970304122","https://openalex.org/W2032617813","https://openalex.org/W2116504572"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"laminin-binding":[2,81],"integrins,":[3],"\u03b13\u03b21":[4,32,136],"and":[5,12,33,68,116,140],"\u03b16\u03b21,":[6],"are":[7,35],"needed":[8],"for":[9,64,74],"tumor":[10,45],"metastasis":[11],"their":[13],"surface":[14],"expression":[15],"is":[16,133],"regulated":[17],"by":[18,37],"endocytic":[19],"recycling.":[20],"\u03b21":[21],"integrins":[22],"share":[23],"the":[24,29,79,100,106],"Rab11":[25,52,107],"recycling":[26,108,122,139,151],"machinery,":[27],"but":[28],"trafficking":[30],"of":[31,96,103,111,120,159],"\u03b16\u03b21":[34,65,75,104,121,132,149],"distinct":[36,134],"an":[38,117,143],"unknown":[39],"mechanism.":[40],"Using":[41],"a":[42,61],"mouse":[43],"PDX":[44],"model":[46],"containing":[47],"human":[48],"metastatic":[49],"prostate":[50,160],"cancer,":[51],"family":[53],"interacting":[54],"protein":[55],"5":[56],"(Rab11-FIP5)":[57],"was":[58],"identified":[59],"as":[60],"lead":[62],"candidate":[63],"trafficking.":[66],"Rab11-FIP5":[67,97,138],"its":[69],"membrane-binding":[70],"domain":[71],"were":[72],"required":[73],"recycling,":[76],"without":[77],"affecting":[78],"other":[80],"integrin":[82,150],"(i.e.,":[83],"\u03b13\u03b21)":[84],"or":[85,93],"unrelated":[86],"membrane":[87],"receptors":[88],"like":[89],"CD44,":[90],"transferrin":[91],"receptor,":[92],"E-cadherin.":[94],"Depletion":[95],"resulted":[98],"in":[99,105,123,142],"intracellular":[101],"accumulation":[102],"compartment,":[109],"loss":[110,119],"cell":[112],"migration":[113,158],"on":[114],"laminin,":[115],"unexpected":[118,144],"cell\u2013cell":[124,145],"locations.":[125],"Taken":[126],"together,":[127],"these":[128],"data":[129],"demonstrate":[130],"that":[131],"from":[135],"via":[137],"recycles":[141],"location.":[146],"Implications:":[147],"Rab11-FIP5\u2013dependent":[148],"may":[152],"be":[153],"selectively":[154],"targeted":[155],"to":[156],"limit":[157],"cancer":[161],"cells":[162],"into":[163],"laminin-rich":[164],"tissues.":[165],"Mol":[166],"Cancer":[167],"Res;":[168],"16(8);":[169],"1319\u201331.":[170],"\u00a92018":[171],"AACR.":[172]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-06T00:00:00"}
