{"id":"https://openalex.org/W4362540971","doi":"https://doi.org/10.1158/1538-7445.am2023-5777","title":"Abstract 5777: Race as a predictive confounder in the rate of transdifferentiation and drug response in human pancreatic acinar ductal metaplasia","display_name":"Abstract 5777: Race as a predictive confounder in the rate of transdifferentiation and drug response in human pancreatic acinar ductal metaplasia","publication_year":2023,"publication_date":"2023-04-04","ids":{"openalex":"https://openalex.org/W4362540971","doi":"https://doi.org/10.1158/1538-7445.am2023-5777"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2023-5777","doi":"https://doi.org/10.1158/1538-7445.am2023-5777","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2023-5777","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031572872","display_name":"Corey Melissa Perkins","orcid":"https://orcid.org/0000-0002-5669-4772","observed_orcids":["https://orcid.org/0000-0002-5669-4772"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Corey Melissa Perkins","raw_affiliation_strings":["1University of Florida, Gainesville, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Florida, Gainesville, FL;","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110253988","display_name":"Jinmai Jiang","orcid":"https://orcid.org/0000-0002-2418-6781","observed_orcids":["https://orcid.org/0000-0002-2418-6781"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinmai Jiang","raw_affiliation_strings":["1University of Florida, Gainesville, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Florida, Gainesville, FL;","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027556445","display_name":"Hesam Hakimjavadi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hesam Hakimjavadi","raw_affiliation_strings":["1University of Florida, Gainesville, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Florida, Gainesville, FL;","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013666609","display_name":"Jason Orr Brant","orcid":"https://orcid.org/0000-0002-9800-9251","observed_orcids":["https://orcid.org/0000-0002-9800-9251"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Brant","raw_affiliation_strings":["1University of Florida, Gainesville, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Florida, Gainesville, FL;","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101782682","display_name":"Zhongyue Zhang","orcid":"https://orcid.org/0000-0002-9585-8581","observed_orcids":["https://orcid.org/0000-0002-9585-8581"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhongyue Zhang","raw_affiliation_strings":["1University of Florida, Gainesville, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Florida, Gainesville, FL;","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100413485","display_name":"Ji\u2010Hyun Lee","orcid":"https://orcid.org/0000-0001-6420-5150","observed_orcids":["https://orcid.org/0000-0001-6420-5150","https://orcid.org/0000-0003-0450-2879"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ji-Hyun Lee","raw_affiliation_strings":["1University of Florida, Gainesville, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Florida, Gainesville, FL;","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088664042","display_name":"David Quashie","orcid":"https://orcid.org/0000-0003-2945-3823","observed_orcids":["https://orcid.org/0000-0003-2945-3823"]},"institutions":[{"id":"https://openalex.org/I8248082","display_name":"Florida Agricultural and Mechanical University","ror":"https://ror.org/00c4wc133","country_code":"US","type":"education","lineage":["https://openalex.org/I8248082"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Quashie","raw_affiliation_strings":["2Florida Agricultural & Mechanical University, Tallahassee, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Florida Agricultural & Mechanical University, Tallahassee, FL","institution_ids":["https://openalex.org/I8248082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057589620","display_name":"Yating Mao","orcid":"https://orcid.org/0009-0002-4907-6519","observed_orcids":["https://orcid.org/0009-0002-4907-6519"]},"institutions":[{"id":"https://openalex.org/I8248082","display_name":"Florida Agricultural and Mechanical University","ror":"https://ror.org/00c4wc133","country_code":"US","type":"education","lineage":["https://openalex.org/I8248082"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yating Mao","raw_affiliation_strings":["2Florida Agricultural & Mechanical University, Tallahassee, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Florida Agricultural & Mechanical University, Tallahassee, FL","institution_ids":["https://openalex.org/I8248082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085539267","display_name":"Jamel Ali","orcid":"https://orcid.org/0000-0002-2997-1981","observed_orcids":["https://orcid.org/0000-0002-2997-1981"]},"institutions":[{"id":"https://openalex.org/I8248082","display_name":"Florida Agricultural and Mechanical University","ror":"https://ror.org/00c4wc133","country_code":"US","type":"education","lineage":["https://openalex.org/I8248082"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamel Ali","raw_affiliation_strings":["2Florida Agricultural & Mechanical University, Tallahassee, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Florida Agricultural & Mechanical University, Tallahassee, FL","institution_ids":["https://openalex.org/I8248082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100654651","display_name":"Sarah Kim","orcid":"https://orcid.org/0000-0002-9179-0735","observed_orcids":["https://orcid.org/0000-0002-9179-0735","https://orcid.org/0009-0000-4001-2899"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Kim","raw_affiliation_strings":["1University of Florida, Gainesville, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Florida, Gainesville, FL;","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090006240","display_name":"Martha Campbell\u2010Thompson","orcid":"https://orcid.org/0000-0001-6878-1235","observed_orcids":["https://orcid.org/0000-0001-6878-1235"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martha Campbell-Thompson","raw_affiliation_strings":["1University of Florida, Gainesville, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Florida, Gainesville, FL;","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001854674","display_name":"Thomas D. Schmittgen","orcid":"https://orcid.org/0000-0002-2812-8546","observed_orcids":["https://orcid.org/0000-0002-2812-8546"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Schmittgen","raw_affiliation_strings":["1University of Florida, Gainesville, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Florida, Gainesville, FL;","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"83","issue":"7_Supplement","first_page":"5777","last_page":"5777"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acinar-to-ductal-metaplasia","display_name":"acinar-to-ductal metaplasia","score":0.824999988079071},{"id":"https://openalex.org/keywords/pancreatic-acinar-cells","display_name":"pancreatic acinar cells","score":0.675000011920929},{"id":"https://openalex.org/keywords/transdifferentiation","display_name":"transdifferentiation","score":0.7269999980926514},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.8410000205039978},{"id":"https://openalex.org/keywords/black-patients","display_name":"Black patients","score":0.7350000143051147},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.8069999814033508},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.9509999752044678},{"id":"https://openalex.org/keywords/viscoelasticity","display_name":"viscoelasticity","score":0.9480000138282776},{"id":"https://openalex.org/keywords/drug-response","display_name":"drug response","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.643559455871582},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6306031346321106},{"id":"https://openalex.org/C60870556","wikidata":"https://www.wikidata.org/wiki/Q2300675","display_name":"Transdifferentiation","level":3,"score":0.6300885081291199},{"id":"https://openalex.org/C2778148616","wikidata":"https://www.wikidata.org/wiki/Q5311600","display_name":"Ductal cells","level":3,"score":0.6218172311782837},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49117276072502136},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4450682997703552},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.44040557742118835},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.34181463718414307},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34160226583480835},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.22989720106124878},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20495223999023438},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2023-5777","doi":"https://doi.org/10.1158/1538-7445.am2023-5777","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.am2023-5777","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8899999856948853}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4309108422","https://openalex.org/W3081716130","https://openalex.org/W4232598235","https://openalex.org/W7222879929","https://openalex.org/W4417202113","https://openalex.org/W7222881362","https://openalex.org/W4389239991","https://openalex.org/W4205431246","https://openalex.org/W3107998767","https://openalex.org/W7166575608"],"abstract_inverted_index":{"Abstract":[0],"Pancreatic":[1],"diseases":[2],"(chronic":[3],"pancreatitis,":[4],"type":[5],"2":[6],"diabetes,":[7],"pancreatic":[8,33,49,66,115,268,318],"cancer)":[9],"disproportionately":[10,104],"affect":[11],"the":[12,29,71,84,103,106,123,127,145,152,156,160,170,178,190,206,240,265,309,326],"Black/African":[13],"American":[14,327],"(AA)":[15],"community":[16],"in":[17,95,114,126,131,138,159,186,204,257,308,316],"comparison":[18],"to":[19,25,43,60,69,168,225,243,252],"non-White":[20],"Hispanics":[21],"and":[22,108,260,273,313,338],"Whites.":[23],"Acinar":[24],"ductal":[26,38,50,320],"metaplasia":[27],"(ADM),":[28],"process":[30,207],"by":[31,230,263,271],"which":[32,100,181,210],"acinar":[34,67,319],"cells":[35,68],"transdifferentiate":[36],"into":[37],"epithelial":[39],"cells,":[40],"is":[41,88,242],"believed":[42],"be":[44],"an":[45,232,254],"initiating":[46],"event":[47],"of":[48,73,86,129,144,162,177,208,267,311,325],"adenocarcinoma.":[51],"Our":[52],"lab":[53],"has":[54,211],"developed":[55],"a":[56,183,199,219,305],"3D":[57],"organoid":[58],"assay":[59],"display":[61],"ADM":[62,87,130,179,233],"using":[63],"primary,":[64],"human":[65,246,317],"study":[70,169],"rate":[72,85,310],"transdifferentiation":[74,312],"amongst":[75],"these":[76,249],"three":[77,250],"different":[78],"races.":[79],"Preliminary":[80],"data":[81],"shows":[82,182],"that":[83,149],"occurring":[89],"significantly":[90],"faster":[91],"(p":[92,222],"<":[93,223],"0.05)":[94,224],"Blacks/AAs":[96,187,217],"(White=16,":[97],"Hispanic=11,":[98],"Black/AA=5),":[99],"may":[101],"explain":[102],"behind":[105],"incidence":[107],"mortality":[109],"rates":[110],"for":[111,189,329],"this":[112],"race":[113,150,259],"cancer.":[116],"A":[117],"sigmoid":[118],"Emax":[119],"function":[120],"best":[121],"captured":[122],"longitudinal":[124],"changes":[125],"percentage":[128,161],"nonlinear":[132],"mixed":[133],"effects":[134],"modeling":[135],"analysis":[136,141],"performed":[137],"Monolix.":[139],"Covariate":[140],"on":[142],"top":[143],"selected":[146],"model":[147],"demonstrated":[148],"was":[151],"only":[153],"covariate":[154],"affecting":[155],"individual":[157],"trajectories":[158],"ADM.":[163],"We":[164],"additionally":[165],"use":[166],"nanoparticles":[167],"biomechanical":[171],"properties":[172],"(I.e.,":[173],"viscoelasticity,":[174],"storage":[175],"modulus)":[176],"microenvironment":[180,185],"stiffer":[184],"than":[188],"other":[191],"races":[192,251],"(White=4,Hispanic=4,":[193],"Black/AA=1).":[194],"Furthermore,":[195],"we":[196],"have":[197],"used":[198],"histone":[200],"deacetylase":[201],"(HDAC)":[202],"inhibitor":[203],"reversing":[205],"ADM,":[209],"consequently":[212],"shown":[213],"race-related":[214],"outcomes,":[215],"with":[216],"displaying":[218],"significant":[220],"chemoresistance":[221],"HDAC":[226],"treatment":[227],"(White=6,Hispanic=6,":[228],"Black/AA=3)":[229],"utilizing":[231],"reversal":[234,262],"index":[235],"(ADMRI).":[236],"Through":[237],"further":[238],"analysis,":[239],"plan":[241],"continue":[244],"procuring":[245],"samples":[247],"from":[248],"isolate":[253],"ADM-specific":[255],"biomarker":[256],"relation":[258],"drug":[261,314],"studying":[264],"expression/activity":[266],"associated":[269],"genes":[270],"bulk-RNA":[272],"single-cell":[274],"sequencing.":[275],"Citation":[276],"Format:":[277],"Corey":[278],"Melissa":[279],"Perkins,":[280],"Jinmai":[281],"Jiang,":[282],"Hesam":[283],"Hakimjavadi,":[284],"Jason":[285],"Brant,":[286],"Zhongyue":[287],"Zhang,":[288],"Ji-Hyun":[289],"Lee,":[290],"David":[291],"Quashie,":[292],"Yating":[293],"Mao,":[294],"Jamel":[295],"Ali,":[296],"Sarah":[297],"Kim,":[298],"Martha":[299],"Campbell-Thompson,":[300],"Thomas":[301],"Schmittgen.":[302],"Race":[303],"as":[304],"predictive":[306],"confounder":[307],"response":[315],"metaplasia.":[321],"[abstract].":[322],"In:":[323],"Proceedings":[324],"Association":[328],"Cancer":[330,349],"Research":[331],"Annual":[332],"Meeting":[333],"2023;":[334],"Part":[335],"1":[336],"(Regular":[337],"Invited":[339],"Abstracts);":[340],"2023":[341],"Apr":[342],"14-19;":[343],"Orlando,":[344],"FL.":[345],"Philadelphia":[346],"(PA):":[347],"AACR;":[348],"Res":[350],"2023;83(7_Suppl):Abstract":[351],"nr":[352],"5777.":[353]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2023-04-06T00:00:00"}