{"id":"https://openalex.org/W4362540732","doi":"https://doi.org/10.1158/2767-9764.22544142","title":"Supplementary Figure 1 from Resolving the Heterogeneous Tumor-Centric Cellular Neighborhood through Multiplexed, Spatial Paracrine Interactions in the Setting of Immune Checkpoint Blockade","display_name":"Supplementary Figure 1 from Resolving the Heterogeneous Tumor-Centric Cellular Neighborhood through Multiplexed, Spatial Paracrine Interactions in the Setting of Immune Checkpoint Blockade","publication_year":2023,"publication_date":"2023-04-04","ids":{"openalex":"https://openalex.org/W4362540732","doi":"https://doi.org/10.1158/2767-9764.22544142"},"language":"en","primary_location":{"id":"doi:10.1158/2767-9764.22544142","doi":"https://doi.org/10.1158/2767-9764.22544142","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.22544142","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_Resolving_the_Heterogeneous_Tumor-Centric_Cellular_Neighborhood_through_Multiplexed_Spatial_Paracrine_Interactions_in_the_Setting_of_Immune_Checkpoint_Blockade/22544142/1/files/40007565.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_Resolving_the_Heterogeneous_Tumor-Centric_Cellular_Neighborhood_through_Multiplexed_Spatial_Paracrine_Interactions_in_the_Setting_of_Immune_Checkpoint_Blockade/22544142/1/files/40007565.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081845545","display_name":"Rachel L.G. Maus","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rachel L.G. Maus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085479273","display_name":"Alexey A. Leontovich","orcid":"https://orcid.org/0009-0002-2014-8996","observed_orcids":["https://orcid.org/0009-0002-2014-8996"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexey A. Leontovich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004159840","display_name":"Raymond M. Moore","orcid":"https://orcid.org/0000-0003-4196-1804","observed_orcids":["https://orcid.org/0000-0003-4196-1804"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raymond M. Moore","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050705116","display_name":"Laura R. E. Becher","orcid":"https://orcid.org/0000-0003-3967-921X","observed_orcids":["https://orcid.org/0000-0003-3967-921X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura Becher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054678780","display_name":"Wendy Kay Nevala","orcid":"https://orcid.org/0009-0004-2256-6715","observed_orcids":["https://orcid.org/0009-0004-2256-6715"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wendy K. Nevala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010963221","display_name":"Thomas James Flotte","orcid":"https://orcid.org/0000-0001-5691-8249","observed_orcids":["https://orcid.org/0000-0001-5691-8249"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas J. Flotte","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Ruifeng Guo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruifeng Guo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061034401","display_name":"Jill M. Schimke","orcid":"https://orcid.org/0000-0001-8844-4391","observed_orcids":["https://orcid.org/0000-0001-8844-4391"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jill M. Schimke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023569036","display_name":"Betty A. Dicke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Betty A. Dicke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049488255","display_name":"Yiyi Yan","orcid":"https://orcid.org/0000-0001-8981-4702","observed_orcids":["https://orcid.org/0000-0001-8981-4702"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yiyi Yan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8981-4702","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5082719040","display_name":"Svetomir N. Markovic","orcid":"https://orcid.org/0000-0002-9238-4325","observed_orcids":["https://orcid.org/0000-0002-9238-4325"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Svetomir N. Markovic","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9238-4325","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8330000042915344},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.7360000014305115},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.9480000138282776},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.6660000085830688},{"id":"https://openalex.org/keywords/spatial-transcriptomics","display_name":"spatial transcriptomics","score":0.5120000243186951},{"id":"https://openalex.org/keywords/cell-classification","display_name":"cell classification","score":0.5680000185966492},{"id":"https://openalex.org/keywords/tumor-infiltrating-immune-cells","display_name":"tumor-infiltrating immune cells","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.7929296493530273},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.7571068406105042},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.6094140410423279},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5046979188919067},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45642775297164917},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4294714331626892},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4120837152004242},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36482399702072144},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3568679094314575},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3492125868797302},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2753433585166931},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22806784510612488},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17765405774116516},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11714467406272888},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10137003660202026},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06409680843353271}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/2767-9764.22544142","doi":"https://doi.org/10.1158/2767-9764.22544142","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.22544142","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_Resolving_the_Heterogeneous_Tumor-Centric_Cellular_Neighborhood_through_Multiplexed_Spatial_Paracrine_Interactions_in_the_Setting_of_Immune_Checkpoint_Blockade/22544142/1/files/40007565.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/2767-9764.22544142.v1","doi":"https://doi.org/10.1158/2767-9764.22544142.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.22544142.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22544142","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_Resolving_the_Heterogeneous_Tumor-Centric_Cellular_Neighborhood_through_Multiplexed_Spatial_Paracrine_Interactions_in_the_Setting_of_Immune_Checkpoint_Blockade/22544142","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/2767-9764.22544142","doi":"https://doi.org/10.1158/2767-9764.22544142","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.22544142","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_Resolving_the_Heterogeneous_Tumor-Centric_Cellular_Neighborhood_through_Multiplexed_Spatial_Paracrine_Interactions_in_the_Setting_of_Immune_Checkpoint_Blockade/22544142/1/files/40007565.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4362540732.pdf","grobid_xml":"https://content.openalex.org/works/W4362540732.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4211061692","https://openalex.org/W7165150926","https://openalex.org/W4362525199","https://openalex.org/W7165173919","https://openalex.org/W7165114421","https://openalex.org/W7165164899","https://openalex.org/W7165206675","https://openalex.org/W7165132511","https://openalex.org/W4404049411","https://openalex.org/W7165194344"],"abstract_inverted_index":{"Phenotypic":[0],"Cell":[1],"Classification":[2],"Tree":[3]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-06T00:00:00"}