{"id":"https://openalex.org/W4362539733","doi":"https://doi.org/10.1158/2326-6066.22537526.v1","title":"Supplementary Fig. S10 from Salmonella-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Coupled with Enzymatic Depletion of Tumor Hyaluronan Induces Complete Regression of Aggressive Pancreatic Tumors","display_name":"Supplementary Fig. S10 from Salmonella-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Coupled with Enzymatic Depletion of Tumor Hyaluronan Induces Complete Regression of Aggressive Pancreatic Tumors","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362539733","doi":"https://doi.org/10.1158/2326-6066.22537526.v1"},"language":"en","primary_location":{"id":"doi:10.1158/2326-6066.22537526.v1","doi":"https://doi.org/10.1158/2326-6066.22537526.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.22537526.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2326-6066.22537526.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075582905","display_name":"Edwin Ramos Manuel","orcid":"https://orcid.org/0000-0002-4602-7060","observed_orcids":["https://orcid.org/0000-0002-4602-7060"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edwin R. Manuel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072814130","display_name":"Jeremy Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeremy Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041131679","display_name":"Massimo D\u2019Apuzzo","orcid":"https://orcid.org/0000-0001-8146-0997","observed_orcids":["https://orcid.org/0000-0001-8146-0997"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Massimo D'Apuzzo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031071719","display_name":"Melanie G. Lampa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melanie G. Lampa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022322002","display_name":"Teodora I. Kaltcheva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Teodora I. Kaltcheva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028896261","display_name":"Curtis B. Thompson","orcid":"https://orcid.org/0009-0004-2649-347X","observed_orcids":["https://orcid.org/0009-0004-2649-347X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Curtis B. Thompson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083991929","display_name":"Thomas G. Ludwig","orcid":"https://orcid.org/0000-0003-4020-6321","observed_orcids":["https://orcid.org/0000-0003-4020-6321","https://orcid.org/0009-0007-7741-9511"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Ludwig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022022603","display_name":"Vincent M. Chung","orcid":"https://orcid.org/0000-0001-9475-808X","observed_orcids":["https://orcid.org/0000-0001-9475-808X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vincent Chung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5022693796","display_name":"Don J. Diamond","orcid":"https://orcid.org/0000-0003-3579-7083","observed_orcids":["https://orcid.org/0000-0003-3579-7083"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Don J. Diamond","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/indoleamine-2-3-dioxygenase","display_name":"indoleamine 2,3-dioxygenase","score":0.9760000109672546},{"id":"https://openalex.org/keywords/pegph20","display_name":"PEGPH20","score":0.8989999890327454},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.6869999766349792},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.8080000281333923},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.8090000152587891},{"id":"https://openalex.org/keywords/shrna-knockdown","display_name":"shRNA knockdown","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C2777527632","wikidata":"https://www.wikidata.org/wiki/Q238382","display_name":"DAPI","level":3,"score":0.9373780488967896},{"id":"https://openalex.org/C83478079","wikidata":"https://www.wikidata.org/wiki/Q908221","display_name":"Indoleamine 2,3-dioxygenase","level":4,"score":0.5893069505691528},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5153145790100098},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46510443091392517},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4308522939682007},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.43057191371917725},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35366448760032654},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35013747215270996},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3463495671749115},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.1043873131275177},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09360465407371521},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2326-6066.22537526.v1","doi":"https://doi.org/10.1158/2326-6066.22537526.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.22537526.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2326-6066.22537526.v1","doi":"https://doi.org/10.1158/2326-6066.22537526.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.22537526.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.4699999988079071,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W1485674412","https://openalex.org/W2360838447","https://openalex.org/W2019516397","https://openalex.org/W2418661930","https://openalex.org/W2167261988","https://openalex.org/W2002586970","https://openalex.org/W2091496351","https://openalex.org/W1921716008"],"abstract_inverted_index":{"Preliminary":[0],"testing":[1],"of":[2,14,42],"PEGPH20/shIDO-ST":[3],"in":[4],"autochthonous":[5,16],"KPC-Brca1":[6,21],"mouse":[7,22],"model.":[8],"PMN":[9],"and":[10,32],"DAPI":[11,39],"immunofluorescence":[12],"staining":[13],"an":[15],"tumor":[17,43,54],"section":[18],"from":[19],"a":[20],"treated":[23],"with":[24,44,52],"PEGPH20/shIDO-ST.":[25],"Tumor":[26],"was":[27],"excised,":[28],"flash":[29],"frozen,":[30],"sectioned,":[31],"stained":[33],"5":[34],"days":[35],"following":[36],"treatment.":[37],"Central":[38],"negative":[40],"region":[41],"neutrophils":[45],"(red)":[46],"is":[47],"depicted":[48],"at":[49,57],"10X":[50],"magnification":[51],"DAPI+":[53],"cells":[55],"(blue)":[56],"upper":[58],"right":[59],"(T).":[60]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2025-10-10T00:00:00"}
