{"id":"https://openalex.org/W4362537475","doi":"https://doi.org/10.1158/1940-6207.22524845","title":"Supplementary Figures from NID2 and HOXA9 Promoter Hypermethylation as Biomarkers for Prevention and Early Detection in Oral Cavity Squamous Cell Carcinoma Tissues and Saliva","display_name":"Supplementary Figures from NID2 and HOXA9 Promoter Hypermethylation as Biomarkers for Prevention and Early Detection in Oral Cavity Squamous Cell Carcinoma Tissues and Saliva","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362537475","doi":"https://doi.org/10.1158/1940-6207.22524845"},"language":"en","primary_location":{"id":"doi:10.1158/1940-6207.22524845","doi":"https://doi.org/10.1158/1940-6207.22524845","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.22524845","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1940-6207.22524845","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048533064","display_name":"Rafael E. Guerrero-Preston","orcid":"https://orcid.org/0000-0002-6639-6488","observed_orcids":["https://orcid.org/0000-0002-6639-6488","https://orcid.org/0000-0002-3069-9583"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Guerrero-Preston","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048648188","display_name":"Ethan Soudry","orcid":"https://orcid.org/0000-0003-4846-7614","observed_orcids":["https://orcid.org/0000-0003-4846-7614"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Soudry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046937996","display_name":"Julio Acero","orcid":"https://orcid.org/0000-0002-0811-1368","observed_orcids":["https://orcid.org/0000-0002-0811-1368"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Acero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050243009","display_name":"M. Orera","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Orera","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103206258","display_name":"Luis Alberto Moreno L\u00f3pez","orcid":"https://orcid.org/0000-0003-1235-7835","observed_orcids":["https://orcid.org/0000-0003-1235-7835"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Moreno-L\u00f3pez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024363455","display_name":"G. Mac\u00eda-Col\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Mac\u00eda-Col\u00f3n","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022131259","display_name":"A. Jaffe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Jaffe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000161292","display_name":"M. Berdasco","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Berdasco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043204404","display_name":"Carmen Ili","orcid":"https://orcid.org/0000-0002-4009-4406","observed_orcids":["https://orcid.org/0000-0002-4009-4406"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Ili-Gangas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078812720","display_name":"P. Brebi-Mieville","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Brebi-Mieville","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113884071","display_name":"Yutao Fu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Fu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047375900","display_name":"C. Engstrom","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Engstrom","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038646454","display_name":"R.A. Irizarry","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R.A. Irizarry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010137759","display_name":"Manel Esteller","orcid":"https://orcid.org/0000-0003-4490-6093","observed_orcids":["https://orcid.org/0000-0003-4490-6093"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Esteller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029012745","display_name":"W. Westra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. Westra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090226949","display_name":"W. Koch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. Koch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088425951","display_name":"J. A. Califano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Califano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5006532610","display_name":"David Sidransky","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Sidransky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.043699998408555984,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.022600000724196434,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nidogen-2","display_name":"NID2","score":0.9589999914169312},{"id":"https://openalex.org/keywords/hoxa9","display_name":"HOXA9","score":0.9990000128746033},{"id":"https://openalex.org/keywords/promoter-hypermethylation","display_name":"promoter hypermethylation","score":0.996999979019165},{"id":"https://openalex.org/keywords/oral-squamous-cell-carcinoma","display_name":"oral squamous cell carcinoma","score":0.8920000195503235},{"id":"https://openalex.org/keywords/salivary-biomarkers","display_name":"salivary biomarkers","score":0.6690000295639038},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.7720000147819519},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.8970000147819519},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9089999794960022}],"concepts":[{"id":"https://openalex.org/C504460877","wikidata":"https://www.wikidata.org/wiki/Q155925","display_name":"Saliva","level":2,"score":0.735877513885498},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.6794184446334839},{"id":"https://openalex.org/C2986629439","wikidata":"https://www.wikidata.org/wiki/Q9635","display_name":"Oral cavity","level":2,"score":0.6561110615730286},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.5357825756072998},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5123502016067505},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45870909094810486},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3226645886898041},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3221522569656372},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2527046799659729},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15392908453941345},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.13956496119499207},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09492364525794983},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07542756199836731}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/1940-6207.22524845","doi":"https://doi.org/10.1158/1940-6207.22524845","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.22524845","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1940-6207.22524845.v1","doi":"https://doi.org/10.1158/1940-6207.22524845.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1940-6207.22524845.v1","pdf_url":"https://aacr.figshare.com/ndownloader/files/39987671","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22524845","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figures_from_NID2_and_HOXA9_Promoter_Hypermethylation_as_Biomarkers_for_Prevention_and_Early_Detection_in_Oral_Cavity_Squamous_Cell_Carcinoma_Tissues_and_Saliva/22524845","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1940-6207.22524845","doi":"https://doi.org/10.1158/1940-6207.22524845","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.22524845","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4362537475.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4392685447","https://openalex.org/W2166286249","https://openalex.org/W3010938966","https://openalex.org/W3158741046","https://openalex.org/W2936797197","https://openalex.org/W4392468195","https://openalex.org/W3051122333","https://openalex.org/W1987727129","https://openalex.org/W6965431163","https://openalex.org/W2166756313"],"abstract_inverted_index":{"Supplementary":[0],"Figures":[1],"from":[2],"NID2":[3],"and":[4,12,22],"HOXA9":[5],"Promoter":[6],"Hypermethylation":[7],"as":[8],"Biomarkers":[9],"for":[10],"Prevention":[11],"Early":[13],"Detection":[14],"in":[15],"Oral":[16],"Cavity":[17],"Squamous":[18],"Cell":[19],"Carcinoma":[20],"Tissues":[21],"Saliva":[23]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-06T00:00:00"}