{"id":"https://openalex.org/W4362535255","doi":"https://doi.org/10.1158/1535-7163.22508167","title":"Supplementary Figures 1-3 from Induction of MNK Kinase\u2013dependent eIF4E Phosphorylation by Inhibitors Targeting BET Proteins Limits Efficacy of BET Inhibitors","display_name":"Supplementary Figures 1-3 from Induction of MNK Kinase\u2013dependent eIF4E Phosphorylation by Inhibitors Targeting BET Proteins Limits Efficacy of BET Inhibitors","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362535255","doi":"https://doi.org/10.1158/1535-7163.22508167"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.22508167","doi":"https://doi.org/10.1158/1535-7163.22508167","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22508167","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1535-7163.22508167","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039554820","display_name":"Thao D. Pham","orcid":"https://orcid.org/0000-0001-7547-0945","observed_orcids":["https://orcid.org/0000-0001-7547-0945"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thao N.D. Pham","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030426208","display_name":"Krishan Kumar","orcid":"https://orcid.org/0000-0003-4406-2644","observed_orcids":["https://orcid.org/0000-0003-4406-2644"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krishan Kumar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087671497","display_name":"Brian T. DeCant","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian T. DeCant","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100699054","display_name":"Meng Shang","orcid":"https://orcid.org/0000-0002-6962-9064","observed_orcids":["https://orcid.org/0000-0002-6962-9064"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meng Shang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075872836","display_name":"Samad Z. Munshi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samad Z. Munshi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081368898","display_name":"Maria Matsangou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Matsangou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012417250","display_name":"Kazumi Ebine","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazumi Ebine","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5001372566","display_name":"Hidayatullah G. Munshi","orcid":"https://orcid.org/0000-0002-9552-0775","observed_orcids":["https://orcid.org/0000-0002-9552-0775"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hidayatullah G. Munshi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eif4e-phosphorylation","display_name":"eIF4E phosphorylation","score":1.0},{"id":"https://openalex.org/keywords/bet-inhibitors","display_name":"BET inhibitors","score":0.9269999861717224},{"id":"https://openalex.org/keywords/papillary-thyroid-carcinoma","display_name":"papillary thyroid carcinoma","score":0.8489999771118164},{"id":"https://openalex.org/keywords/cytoskeletal-genes","display_name":"cytoskeletal genes","score":0.6320000290870667},{"id":"https://openalex.org/keywords/mnk-inhibitors","display_name":"MNK inhibitors","score":0.8870000243186951},{"id":"https://openalex.org/keywords/otx015","display_name":"OTX015","score":0.9760000109672546},{"id":"https://openalex.org/keywords/arv-825","display_name":"ARV-825","score":0.9919999837875366},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6880000233650208},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5220596790313721},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4693352282047272},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39526456594467163},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.393757164478302},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36212462186813354},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3245616853237152},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.30489879846572876}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/1535-7163.22508167","doi":"https://doi.org/10.1158/1535-7163.22508167","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22508167","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1535-7163.22508167.v1","doi":"https://doi.org/10.1158/1535-7163.22508167.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22508167.v1","pdf_url":"https://aacr.figshare.com/ndownloader/files/39969985","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22508167","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figures_1-3_from_Induction_of_MNK_Kinase_dependent_eIF4E_Phosphorylation_by_Inhibitors_Targeting_BET_Proteins_Limits_Efficacy_of_BET_Inhibitors/22508167","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.22508167","doi":"https://doi.org/10.1158/1535-7163.22508167","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22508167","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4362535255.pdf","grobid_xml":"https://content.openalex.org/works/W4362535255.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4392698281","https://openalex.org/W2900560643","https://openalex.org/W2886252408","https://openalex.org/W4251694087","https://openalex.org/W2088691227","https://openalex.org/W2034713747","https://openalex.org/W7010703298","https://openalex.org/W3143994745","https://openalex.org/W2025565532","https://openalex.org/W2100468603"],"abstract_inverted_index":{"Fig.":[0,11,22],"S1":[1],"-":[2,13,24],"eIF4E":[3],"expression":[4],"and":[5,29],"survival":[6],"data":[7],"for":[8],"papillary":[9],"thyroid.":[10],"S2":[12],"Effect":[14],"of":[15,26],"BET":[16],"inhibitors":[17,28],"on":[18],"genes":[19],"regulating":[20],"cytoskeleton":[21],"S3":[23],"combination":[25],"MNK":[27],"OTX015":[30],"or":[31],"ARV-825":[32]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-06T00:00:00"}