{"id":"https://openalex.org/W4362533003","doi":"https://doi.org/10.1158/2767-9764.22545422","title":"Supplementary Fig. S6 from Loss of Vascular Endothelial Glutaminase Inhibits Tumor Growth and Metastasis, and Increases Sensitivity to Chemotherapy","display_name":"Supplementary Fig. S6 from Loss of Vascular Endothelial Glutaminase Inhibits Tumor Growth and Metastasis, and Increases Sensitivity to Chemotherapy","publication_year":2023,"publication_date":"2023-04-04","ids":{"openalex":"https://openalex.org/W4362533003","doi":"https://doi.org/10.1158/2767-9764.22545422"},"language":"en","primary_location":{"id":"doi:10.1158/2767-9764.22545422","doi":"https://doi.org/10.1158/2767-9764.22545422","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2767-9764.22545422","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Fig_S6_from_Loss_of_Vascular_Endothelial_Glutaminase_Inhibits_Tumor_Growth_and_Metastasis_and_Increases_Sensitivity_to_Chemotherapy/22545422/1/files/40008854.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Fig_S6_from_Loss_of_Vascular_Endothelial_Glutaminase_Inhibits_Tumor_Growth_and_Metastasis_and_Increases_Sensitivity_to_Chemotherapy/22545422/1/files/40008854.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036235661","display_name":"Verra M. Ngwa","orcid":"https://orcid.org/0000-0002-8878-4350","observed_orcids":["https://orcid.org/0000-0002-8878-4350"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Verra M. Ngwa","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8878-4350","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031420382","display_name":"Deanna N. Edwards","orcid":"https://orcid.org/0000-0001-5481-5879","observed_orcids":["https://orcid.org/0000-0001-5481-5879"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Deanna N. Edwards","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5481-5879","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091689383","display_name":"Yoonha Hwang","orcid":"https://orcid.org/0000-0001-7420-4477","observed_orcids":["https://orcid.org/0000-0001-7420-4477"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoonha Hwang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7420-4477","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009967532","display_name":"Breelyn A. Karno","orcid":"https://orcid.org/0000-0003-4498-5318","observed_orcids":["https://orcid.org/0000-0003-4498-5318"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Breelyn Karno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082389697","display_name":"Xiaoyong Wang","orcid":"https://orcid.org/0000-0002-9667-2316","observed_orcids":["https://orcid.org/0000-0002-9667-2316"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoyong Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9667-2316","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007111794","display_name":"Chi Wing Yan","orcid":"https://orcid.org/0000-0002-8658-7302","observed_orcids":["https://orcid.org/0000-0002-8658-7302"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chi Yan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8658-7302","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010542605","display_name":"Ann J. Richmond","orcid":"https://orcid.org/0000-0002-9580-900X","observed_orcids":["https://orcid.org/0000-0002-9580-900X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ann Richmond","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9580-900X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004009810","display_name":"Dana M. Brantley\u2010Sieders","orcid":"https://orcid.org/0000-0002-2751-6547","observed_orcids":["https://orcid.org/0000-0002-2751-6547","https://orcid.org/0000-0001-9873-6339"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dana M. Brantley-Sieders","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5020742692","display_name":"Jin Chen","orcid":"https://orcid.org/0000-0002-5557-2079","observed_orcids":["https://orcid.org/0000-0002-5557-2079"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jin Chen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5557-2079","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.5503000020980835,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.5503000020980835,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.3698999881744385,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.0333000011742115,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutaminase","display_name":"glutaminase","score":0.765999972820282},{"id":"https://openalex.org/keywords/gls","display_name":"GLS","score":0.6549999713897705},{"id":"https://openalex.org/keywords/gls2","display_name":"GLS2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.8939999938011169},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.6769999861717224},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/chemosensitivity","display_name":"chemosensitivity","score":0.9409999847412109},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7990000247955322},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.8870000243186951},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.9330000281333923},{"id":"https://openalex.org/keywords/gene-set-enrichment-analysis","display_name":"gene set enrichment analysis","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6223719120025635},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5978567004203796},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5493766665458679},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5470860004425049},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.52914959192276},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42536303400993347},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4146270751953125},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.24760720133781433},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23706945776939392}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/2767-9764.22545422","doi":"https://doi.org/10.1158/2767-9764.22545422","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2767-9764.22545422","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Fig_S6_from_Loss_of_Vascular_Endothelial_Glutaminase_Inhibits_Tumor_Growth_and_Metastasis_and_Increases_Sensitivity_to_Chemotherapy/22545422/1/files/40008854.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/2767-9764.22545422.v1","doi":"https://doi.org/10.1158/2767-9764.22545422.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.22545422.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22545422","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Fig_S6_from_Loss_of_Vascular_Endothelial_Glutaminase_Inhibits_Tumor_Growth_and_Metastasis_and_Increases_Sensitivity_to_Chemotherapy/22545422","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/2767-9764.22545422","doi":"https://doi.org/10.1158/2767-9764.22545422","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2767-9764.22545422","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Fig_S6_from_Loss_of_Vascular_Endothelial_Glutaminase_Inhibits_Tumor_Growth_and_Metastasis_and_Increases_Sensitivity_to_Chemotherapy/22545422/1/files/40008854.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4362533003.pdf","grobid_xml":"https://content.openalex.org/works/W4362533003.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4286424198","https://openalex.org/W3081769843","https://openalex.org/W2768589048","https://openalex.org/W2085114523","https://openalex.org/W2151787127","https://openalex.org/W2981920802","https://openalex.org/W2571420520","https://openalex.org/W7096163392","https://openalex.org/W3093386110","https://openalex.org/W7009570887"],"abstract_inverted_index":{"This":[0],"figure":[1],"shows":[2],"volcano":[3],"plots":[4],"of":[5,27,33],"differentially":[6,15],"expressed":[7],"genes":[8,37],"in":[9,38],"GLSECKO":[10,39],"versus":[11,40],"WT":[12],"endothelial":[13],"cell,":[14],"enriched":[16],"pathways":[17],"up":[18],"and":[19,35],"down,":[20],"Gene":[21],"set":[22],"enrichment":[23],"analysis,":[24],"-log":[25],"FPKM":[26],"Gls,":[28],"Gls2,":[29],"angiogenic":[30,36],"genes,":[31],"qRT-PCR":[32],"leptin":[34],"WT.":[41]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-06T00:00:00"}