{"id":"https://openalex.org/W4362531322","doi":"https://doi.org/10.1158/2159-8290.22529780","title":"Supplementary Figure 4 from Parallel RNA Interference Screens Identify EGFR Activation as an Escape Mechanism in FGFR3-Mutant Cancer","display_name":"Supplementary Figure 4 from Parallel RNA Interference Screens Identify EGFR Activation as an Escape Mechanism in FGFR3-Mutant Cancer","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362531322","doi":"https://doi.org/10.1158/2159-8290.22529780"},"language":"en","primary_location":{"id":"doi:10.1158/2159-8290.22529780","doi":"https://doi.org/10.1158/2159-8290.22529780","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2159-8290.22529780","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_Parallel_RNA_Interference_Screens_Identify_EGFR_Activation_as_an_Escape_Mechanism_in_i_FGFR3_i_-Mutant_Cancer/22529780/1/files/39992897.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_Parallel_RNA_Interference_Screens_Identify_EGFR_Activation_as_an_Escape_Mechanism_in_i_FGFR3_i_-Mutant_Cancer/22529780/1/files/39992897.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048310310","display_name":"Mar\u00eda Teresa Herrera-Abreu","orcid":"https://orcid.org/0000-0002-6953-3919","observed_orcids":["https://orcid.org/0000-0002-6953-3919"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Teresa Herrera-Abreu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031626209","display_name":"Alexander T. Pearson","orcid":"https://orcid.org/0000-0003-2801-7456","observed_orcids":["https://orcid.org/0000-0003-2801-7456"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alex Pearson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037413369","display_name":"James R. Campbell","orcid":"https://orcid.org/0000-0003-0251-4550","observed_orcids":["https://orcid.org/0000-0003-0251-4550"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Campbell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013810423","display_name":"Steven D. Shnyder","orcid":"https://orcid.org/0000-0002-4647-2340","observed_orcids":["https://orcid.org/0000-0002-4647-2340"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steve D. Shnyder","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064065033","display_name":"Margaret A. Knowles","orcid":"https://orcid.org/0000-0002-9363-8657","observed_orcids":["https://orcid.org/0000-0002-9363-8657"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Margaret A. Knowles","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058973407","display_name":"Alan Ashworth","orcid":"https://orcid.org/0000-0003-1446-7878","observed_orcids":["https://orcid.org/0000-0003-1446-7878","https://orcid.org/0009-0008-8974-2233"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alan Ashworth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5060044961","display_name":"Nicholas C. Turner","orcid":"https://orcid.org/0000-0001-8937-0873","observed_orcids":["https://orcid.org/0000-0001-8937-0873"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicholas C. Turner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0340999998152256,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/egfr-activation","display_name":"EGFR activation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/fgfr3-mutation","display_name":"FGFR3 mutation","score":0.972000002861023},{"id":"https://openalex.org/keywords/fgfr-inhibitors","display_name":"FGFR inhibitors","score":0.9419999718666077},{"id":"https://openalex.org/keywords/rnai-screen","display_name":"RNAi screen","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7915278673171997},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6985096335411072},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.684777021408081},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.55455482006073},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.49315327405929565},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4224855601787567},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3881930410861969},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31161484122276306},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.27687835693359375},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18685239553451538},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13510116934776306},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07804948091506958},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/2159-8290.22529780","doi":"https://doi.org/10.1158/2159-8290.22529780","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2159-8290.22529780","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_Parallel_RNA_Interference_Screens_Identify_EGFR_Activation_as_an_Escape_Mechanism_in_i_FGFR3_i_-Mutant_Cancer/22529780/1/files/39992897.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/2159-8290.22529780.v1","doi":"https://doi.org/10.1158/2159-8290.22529780.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.22529780.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22529780","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_Parallel_RNA_Interference_Screens_Identify_EGFR_Activation_as_an_Escape_Mechanism_in_i_FGFR3_i_-Mutant_Cancer/22529780","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/2159-8290.22529780","doi":"https://doi.org/10.1158/2159-8290.22529780","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2159-8290.22529780","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_Parallel_RNA_Interference_Screens_Identify_EGFR_Activation_as_an_Escape_Mechanism_in_i_FGFR3_i_-Mutant_Cancer/22529780/1/files/39992897.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4362531322.pdf","grobid_xml":"https://content.openalex.org/works/W4362531322.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4392721877","https://openalex.org/W2165267819","https://openalex.org/W4292927618","https://openalex.org/W4362622926","https://openalex.org/W2284030464","https://openalex.org/W4362530008","https://openalex.org/W2329055446","https://openalex.org/W1994075309","https://openalex.org/W2413757546","https://openalex.org/W2773199635"],"abstract_inverted_index":{"Supplementary":[0],"Figure":[1],"4":[2],"-":[3],"PDF":[4],"file":[5],"354K,":[6],"Analysis":[7],"of":[8,19],"the":[9],"effects":[10],"on":[11],"combined":[12],"EGFR":[13,20],"and":[14,17],"FGFR3":[15],"inhibition,":[16],"mechanism":[18],"upregulation":[21],"by":[22],"FGFR":[23],"inhibitors":[24]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-06T00:00:00"}