{"id":"https://openalex.org/W4362529353","doi":"https://doi.org/10.1158/1541-7786.22514850","title":"Supplementary Figure S2 from Metabolic Profiling of Formalin-Fixed Paraffin-Embedded Tissues Discriminates Normal Colon from Colorectal Cancer","display_name":"Supplementary Figure S2 from Metabolic Profiling of Formalin-Fixed Paraffin-Embedded Tissues Discriminates Normal Colon from Colorectal Cancer","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362529353","doi":"https://doi.org/10.1158/1541-7786.22514850"},"language":"en","primary_location":{"id":"doi:10.1158/1541-7786.22514850","doi":"https://doi.org/10.1158/1541-7786.22514850","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.22514850","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1541-7786.22514850","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103764289","display_name":"Kota Arima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kota Arima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011420562","display_name":"Mai Chan Lau","orcid":"https://orcid.org/0000-0002-7698-4697","observed_orcids":["https://orcid.org/0000-0002-7698-4697"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mai Chan Lau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033150413","display_name":"Melissa M. Zhao","orcid":"https://orcid.org/0000-0002-5190-3635","observed_orcids":["https://orcid.org/0000-0002-5190-3635"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melissa Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037753214","display_name":"Koichiro Haruki","orcid":"https://orcid.org/0000-0002-1686-3228","observed_orcids":["https://orcid.org/0000-0002-1686-3228"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Koichiro Haruki","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1686-3228","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064146636","display_name":"Keisuke Kosumi","orcid":"https://orcid.org/0000-0003-4028-1137","observed_orcids":["https://orcid.org/0000-0003-4028-1137"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keisuke Kosumi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035573322","display_name":"Kosuke Mima","orcid":"https://orcid.org/0000-0002-4385-4984","observed_orcids":["https://orcid.org/0000-0002-4385-4984"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kosuke Mima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103188059","display_name":"Mancang Gu","orcid":"https://orcid.org/0000-0003-3782-0988","observed_orcids":["https://orcid.org/0000-0003-3782-0988"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mancang Gu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078974511","display_name":"Juha P. V\u00e4yrynen","orcid":"https://orcid.org/0000-0002-8683-2996","observed_orcids":["https://orcid.org/0000-0002-8683-2996"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juha P. V\u00e4yrynen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8683-2996","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040066867","display_name":"Tyler S. Twombly","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tyler S. Twombly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101184836","display_name":"Yoshifumi Baba","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshifumi Baba","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086088975","display_name":"Kenji Fujiyoshi","orcid":"https://orcid.org/0000-0002-0310-5807","observed_orcids":["https://orcid.org/0000-0002-0310-5807"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenji Fujiyoshi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0310-5807","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033860416","display_name":"Junko Kishikawa","orcid":"https://orcid.org/0000-0003-0590-6736","observed_orcids":["https://orcid.org/0000-0003-0590-6736"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Junko Kishikawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Chunguang Guo","orcid":"https://orcid.org/0000-0002-2674-6586","observed_orcids":["https://orcid.org/0000-0002-2674-6586"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chunguang Guo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2674-6586","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109472611","display_name":"Hideo Baba","orcid":"https://orcid.org/0000-0002-3183-3115","observed_orcids":["https://orcid.org/0000-0002-3183-3115"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hideo Baba","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036450155","display_name":"William G. Richards","orcid":"https://orcid.org/0000-0003-0990-8317","observed_orcids":["https://orcid.org/0000-0003-0990-8317"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William G. Richards","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068835941","display_name":"Andrew Tan Chan","orcid":"https://orcid.org/0000-0001-7284-6767","observed_orcids":["https://orcid.org/0000-0001-7284-6767","https://orcid.org/0000-0002-3662-5964","https://orcid.org/0000-0002-5436-4219"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew T. Chan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085236177","display_name":"Reiko Nishihara","orcid":"https://orcid.org/0000-0002-2579-9141","observed_orcids":["https://orcid.org/0000-0002-2579-9141"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reiko Nishihara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027170448","display_name":"Jeffrey A. Meyerhardt","orcid":"https://orcid.org/0000-0002-1120-0898","observed_orcids":["https://orcid.org/0000-0002-1120-0898"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey A. Meyerhardt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058614093","display_name":"Jonathan Andrew Nowak","orcid":"https://orcid.org/0000-0002-0943-7407","observed_orcids":["https://orcid.org/0000-0002-0943-7407"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan A. Nowak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048568172","display_name":"Marios Giannakis","orcid":"https://orcid.org/0000-0001-9012-6982","observed_orcids":["https://orcid.org/0000-0001-9012-6982"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marios Giannakis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049314303","display_name":"Charles S. Fuchs","orcid":"https://orcid.org/0000-0003-1582-9842","observed_orcids":["https://orcid.org/0000-0003-1582-9842"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles S. Fuchs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5076818447","display_name":"Shuji Ogino","orcid":"https://orcid.org/0000-0002-3909-2323","observed_orcids":["https://orcid.org/0000-0002-3909-2323"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuji Ogino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.8300999999046326,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.8300999999046326,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.036400001496076584,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9259999990463257},{"id":"https://openalex.org/keywords/metabolic-profiling","display_name":"metabolite profiling","score":0.6890000104904175},{"id":"https://openalex.org/keywords/formalin-fixed-paraffin-embedded-tissue","display_name":"formalin-fixed paraffin-embedded tissue","score":0.9509999752044678},{"id":"https://openalex.org/keywords/carbohydrates","display_name":"carbohydrates","score":0.7689999938011169},{"id":"https://openalex.org/keywords/xenobiotics","display_name":"xenobiotics","score":0.9990000128746033},{"id":"https://openalex.org/keywords/energy-metabolites","display_name":"energy metabolites","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-versus-normal-tissue-discrimination","display_name":"tumor versus normal tissue discrimination","score":0.7379999756813049},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.3840000033378601}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7384108901023865},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.6404777765274048},{"id":"https://openalex.org/C115448650","wikidata":"https://www.wikidata.org/wiki/Q409205","display_name":"Xenobiotic","level":3,"score":0.5660028457641602},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47928184270858765},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.44344037771224976},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.345872163772583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3240818381309509},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2879561185836792},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2809160351753235},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20999842882156372},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13263121247291565}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1541-7786.22514850","doi":"https://doi.org/10.1158/1541-7786.22514850","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.22514850","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1541-7786.22514850","doi":"https://doi.org/10.1158/1541-7786.22514850","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.22514850","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3012489703","https://openalex.org/W4392699612","https://openalex.org/W4362485877","https://openalex.org/W4362485873","https://openalex.org/W7148654288","https://openalex.org/W4362483532","https://openalex.org/W4362483436","https://openalex.org/W2527138435","https://openalex.org/W4362485867","https://openalex.org/W4362485754"],"abstract_inverted_index":{"Supplementary":[0],"Figure":[1],"S2.":[2],"Distribution":[3],"of":[4,18,48],"carbohydrates,":[5],"xenobiotics,":[6],"cofactors":[7,26],"and":[8,10,14,27,30,39],"vitamins,":[9],"energy":[11,32],"in":[12],"tumor":[13],"normal.":[15],"(A-D):":[16],"Heatmap":[17],"8":[19],"carbohydrates":[20],"(A),":[21],"7":[22,25,31],"xenobiotics":[23],"(B),":[24],"vitamins":[28],"(C),":[29],"metabolites":[33],"(D)":[34],"sorted":[35],"by":[36],"sample":[37],"types":[38],"then":[40],"tissue":[41],"types.":[42],"Heat-map":[43],"colors":[44],"represent":[45],"z-score":[46],"values":[47],"raw":[49],"detection":[50],"amount.":[51],"FFPE,":[52],"formalin-fixed":[53],"paraffin-embedded;":[54],"N,":[55],"normal;":[56],"T,":[57],"tumor.":[58]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2023-04-06T00:00:00"}