{"id":"https://openalex.org/W4362528101","doi":"https://doi.org/10.1158/1535-7163.22506658","title":"Supplemental Figure 2 from ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer\u2013Containing Antibody\u2013Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies","display_name":"Supplemental Figure 2 from ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer\u2013Containing Antibody\u2013Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362528101","doi":"https://doi.org/10.1158/1535-7163.22506658"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.22506658","doi":"https://doi.org/10.1158/1535-7163.22506658","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22506658","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1535-7163.22506658","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Michael J. Flynn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael J. Flynn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039617409","display_name":"Francesca Zammarchi","orcid":"https://orcid.org/0000-0001-9457-2170","observed_orcids":["https://orcid.org/0000-0001-9457-2170"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesca Zammarchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036657281","display_name":"Peter C. Tyrer","orcid":"https://orcid.org/0000-0001-8004-5396","observed_orcids":["https://orcid.org/0000-0001-8004-5396"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter C. Tyrer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067431043","display_name":"Ayse U. Akarca","orcid":"https://orcid.org/0000-0003-0629-3927","observed_orcids":["https://orcid.org/0000-0003-0629-3927"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ayse U. Akarca","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077270688","display_name":"Narinder Janghra","orcid":"https://orcid.org/0000-0002-2816-8281","observed_orcids":["https://orcid.org/0000-0002-2816-8281"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Narinder Janghra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054078946","display_name":"Charles E. Britten","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles E. Britten","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111968453","display_name":"Carin E.G. Havenith","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carin E.G. Havenith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089413145","display_name":"Jean-Noel Levy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean-Noel Levy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047010658","display_name":"Arnaud C. Tiberghien","orcid":"https://orcid.org/0000-0002-2936-0515","observed_orcids":["https://orcid.org/0000-0002-2936-0515"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arnaud Tiberghien","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044830291","display_name":"Luke A. Masterson","orcid":"https://orcid.org/0000-0002-5366-4025","observed_orcids":["https://orcid.org/0000-0002-5366-4025"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luke A. Masterson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Conor Barry","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Conor Barry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014171089","display_name":"Fran\u00e7ois D\u2019Hooge","orcid":"https://orcid.org/0000-0003-2531-085X","observed_orcids":["https://orcid.org/0000-0003-2531-085X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francois D'Hooge","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001737873","display_name":"Teresa Marafioti","orcid":"https://orcid.org/0000-0003-1223-6275","observed_orcids":["https://orcid.org/0000-0003-1223-6275"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Teresa Marafioti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039190287","display_name":"Paul W.H.I. Parren","orcid":"https://orcid.org/0000-0002-4365-3859","observed_orcids":["https://orcid.org/0000-0002-4365-3859"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul W.H.I. Parren","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"David G. Williams","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David G. Williams","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051368970","display_name":"Philip W. Howard","orcid":"https://orcid.org/0000-0001-6392-2289","observed_orcids":["https://orcid.org/0000-0001-6392-2289","https://orcid.org/0000-0001-7828-1154"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philip W. Howard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006107477","display_name":"Patrick H. van Berkel","orcid":"https://orcid.org/0000-0002-7315-0347","observed_orcids":["https://orcid.org/0000-0002-7315-0347"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick H. van Berkel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5055669649","display_name":"John Anthony Hartley","orcid":"https://orcid.org/0000-0003-3737-9897","observed_orcids":["https://orcid.org/0000-0003-3737-9897"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John A. Hartley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13105","display_name":"Synthesis and pharmacology of benzodiazepine derivatives","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13105","display_name":"Synthesis and pharmacology of benzodiazepine derivatives","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.03350000083446503,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyrrolobenzodiazepine-dimer","display_name":"pyrrolobenzodiazepine dimer","score":0.9580000042915344},{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cd25","display_name":"CD25","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.9589999914169312},{"id":"https://openalex.org/keywords/mts-assay","display_name":"MTS assay","score":0.7009999752044678},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C2777325958","wikidata":"https://www.wikidata.org/wiki/Q1069596","display_name":"Antibody-drug conjugate","level":4,"score":0.8863621950149536},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.7983644604682922},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.48398923873901367},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.47228413820266724},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4668126106262207},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4390754699707031},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42813628911972046},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38511064648628235},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3066231608390808},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.20069843530654907},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19677752256393433},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1777801811695099},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.22506658","doi":"https://doi.org/10.1158/1535-7163.22506658","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22506658","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.22506658","doi":"https://doi.org/10.1158/1535-7163.22506658","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22506658","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2513682949","https://openalex.org/W4392688337","https://openalex.org/W857936328","https://openalex.org/W2479943337","https://openalex.org/W2922123088","https://openalex.org/W2740746026","https://openalex.org/W2889961083","https://openalex.org/W4229831668","https://openalex.org/W2624175890","https://openalex.org/W7164993936"],"abstract_inverted_index":{"MTS":[0],"assays":[1],"on":[2],"cell":[3],"lines":[4],"after":[5],"treatment":[6],"with":[7],"ADCT-301,":[8],"Non-binding":[9],"ADC":[10],"and":[11],"naked":[12],"antibody,":[13],"HuMax-TAC":[14]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2023-04-06T00:00:00"}
