{"id":"https://openalex.org/W4362528091","doi":"https://doi.org/10.1158/1535-7163.22506648","title":"Supplementary Materials and Methods from Cyclophosphamide-Mediated Tumor Priming for Enhanced Delivery and Antitumor Activity of HER2-Targeted Liposomal Doxorubicin (MM-302)","display_name":"Supplementary Materials and Methods from Cyclophosphamide-Mediated Tumor Priming for Enhanced Delivery and Antitumor Activity of HER2-Targeted Liposomal Doxorubicin (MM-302)","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362528091","doi":"https://doi.org/10.1158/1535-7163.22506648"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.22506648","doi":"https://doi.org/10.1158/1535-7163.22506648","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22506648","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1535-7163.22506648","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010258163","display_name":"Elena Geretti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elena Geretti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110967781","display_name":"Shannon Curtis Leonard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shannon Curtis Leonard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000501575","display_name":"Nancy Dumont","orcid":"https://orcid.org/0000-0002-6565-0851","observed_orcids":["https://orcid.org/0000-0002-6565-0851"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nancy Dumont","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062646947","display_name":"Helen Lee","orcid":"https://orcid.org/0000-0002-2379-6940","observed_orcids":["https://orcid.org/0000-0002-2379-6940"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helen Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043469140","display_name":"Jinzi Zheng","orcid":"https://orcid.org/0000-0002-7650-3910","observed_orcids":["https://orcid.org/0000-0002-7650-3910"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jinzi Zheng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057874572","display_name":"Raquel De Souza","orcid":"https://orcid.org/0000-0001-5502-6329","observed_orcids":["https://orcid.org/0000-0001-5502-6329"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raquel De Souza","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112086621","display_name":"Daniel F. Gaddy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel F. Gaddy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066151215","display_name":"Christopher W. Espelin","orcid":"https://orcid.org/0000-0002-2099-0609","observed_orcids":["https://orcid.org/0000-0002-2099-0609"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher W. Espelin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008048551","display_name":"David Anthony Jaffray","orcid":"https://orcid.org/0000-0001-7378-7543","observed_orcids":["https://orcid.org/0000-0001-7378-7543"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David A. Jaffray","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059232093","display_name":"Victor M. Moyo","orcid":"https://orcid.org/0000-0001-8470-5347","observed_orcids":["https://orcid.org/0000-0001-8470-5347"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Victor Moyo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008861678","display_name":"Ulrik B. Nielsen","orcid":"https://orcid.org/0000-0002-6475-7606","observed_orcids":["https://orcid.org/0000-0002-6475-7606"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ulrik B. Nielsen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110478756","display_name":"Thomas J. Wickham","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas J. Wickham","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5035474346","display_name":"Bart S. Hendriks","orcid":"https://orcid.org/0000-0002-4219-4945","observed_orcids":["https://orcid.org/0000-0002-4219-4945"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bart S. Hendriks","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.9670000076293945},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.8309999704360962},{"id":"https://openalex.org/keywords/liposomal-doxorubicin","display_name":"liposomal doxorubicin","score":0.9670000076293945},{"id":"https://openalex.org/keywords/liposome-preparation","display_name":"liposome preparation","score":0.8209999799728394},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8880000114440918},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.6660000085830688},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.7733228206634521},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.7716892957687378},{"id":"https://openalex.org/C81444415","wikidata":"https://www.wikidata.org/wiki/Q7243535","display_name":"Priming (agriculture)","level":3,"score":0.569552481174469},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.47345632314682007},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4217653274536133},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4172768294811249},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37577515840530396},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34266650676727295},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3157588243484497},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2726508677005768},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2628821134567261},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.24535295367240906},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2363232672214508},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17385348677635193},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12902286648750305},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12814971804618835},{"id":"https://openalex.org/C100701293","wikidata":"https://www.wikidata.org/wiki/Q193838","display_name":"Germination","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/1535-7163.22506648","doi":"https://doi.org/10.1158/1535-7163.22506648","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22506648","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1535-7163.22506648.v1","doi":"https://doi.org/10.1158/1535-7163.22506648.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22506648.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22506648","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Materials_and_Methods_from_Cyclophosphamide-Mediated_Tumor_Priming_for_Enhanced_Delivery_and_Antitumor_Activity_of_HER2-Targeted_Liposomal_Doxorubicin_MM-302_/22506648","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.22506648","doi":"https://doi.org/10.1158/1535-7163.22506648","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22506648","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4392688411","https://openalex.org/W2331368728","https://openalex.org/W2113506065","https://openalex.org/W375847331","https://openalex.org/W7100361905","https://openalex.org/W7100196643","https://openalex.org/W1584845979","https://openalex.org/W2479692189","https://openalex.org/W2589089516","https://openalex.org/W4236442722"],"abstract_inverted_index":{"Supplementary":[0],"Materials":[1],"and":[2,21],"Methods.":[3],"This":[4],"file":[5],"contains":[6],"information":[7],"on":[8,23],"the":[9,13,24],"reagents,":[10],"methods":[11],"for":[12],"evaluation":[14],"of":[15,19],"cell":[16],"viability,":[17],"preparation":[18],"liposomes":[20],"details":[22],"image":[25],"analysis.":[26]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-06T00:00:00"}