{"id":"https://openalex.org/W4362525863","doi":"https://doi.org/10.1158/1535-7163.22496724","title":"Supplementary Figure 4 from A Molecular Screening Approach to Identify and Characterize Inhibitors of Glioblastoma Stem Cells","display_name":"Supplementary Figure 4 from A Molecular Screening Approach to Identify and Characterize Inhibitors of Glioblastoma Stem Cells","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362525863","doi":"https://doi.org/10.1158/1535-7163.22496724"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.22496724","doi":"https://doi.org/10.1158/1535-7163.22496724","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22496724","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_A_Molecular_Screening_Approach_to_Identify_and_Characterize_Inhibitors_of_Glioblastoma_Stem_Cells/22496724/1/files/39954750.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_A_Molecular_Screening_Approach_to_Identify_and_Characterize_Inhibitors_of_Glioblastoma_Stem_Cells/22496724/1/files/39954750.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023378099","display_name":"Koppany Visnyei","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Koppany Visnyei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110967773","display_name":"Hideyuki Onodera","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hideyuki Onodera","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045676945","display_name":"Robert D. Damoiseaux","orcid":"https://orcid.org/0000-0002-7611-7534","observed_orcids":["https://orcid.org/0000-0002-7611-7534"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Damoiseaux","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041677467","display_name":"Kuniyasu Saigusa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kuniyasu Saigusa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084034333","display_name":"Syuzanna Petrosyan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Syuzanna Petrosyan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112905627","display_name":"David DE VRIES","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David De Vries","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071812459","display_name":"Denise Ferrari","orcid":"https://orcid.org/0000-0001-6473-6293","observed_orcids":["https://orcid.org/0000-0001-6473-6293"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Denise Ferrari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Jonathan Saxe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan Saxe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044220421","display_name":"Eduard H. Panosyan","orcid":"https://orcid.org/0000-0003-1701-1251","observed_orcids":["https://orcid.org/0000-0003-1701-1251"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eduard H. Panosyan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048608426","display_name":"Michael D. Masterman-Smith","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Masterman-Smith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037036753","display_name":"Jack Mottahedeh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jack Mottahedeh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056283289","display_name":"Kenneth A. Bradley","orcid":"https://orcid.org/0000-0002-4757-5122","observed_orcids":["https://orcid.org/0000-0002-4757-5122"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenneth A. Bradley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100757495","display_name":"Jing Huang","orcid":"https://orcid.org/0000-0002-9607-7250","observed_orcids":["https://orcid.org/0000-0002-9607-7250"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037586820","display_name":"Chiara Sabatti","orcid":"https://orcid.org/0000-0001-5829-9058","observed_orcids":["https://orcid.org/0000-0001-5829-9058"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chiara Sabatti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037386621","display_name":"Ichiro Nakano","orcid":"https://orcid.org/0000-0002-0916-3207","observed_orcids":["https://orcid.org/0000-0002-0916-3207"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ichiro Nakano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5062310885","display_name":"Harley I. Kornblum","orcid":"https://orcid.org/0000-0002-3779-4540","observed_orcids":["https://orcid.org/0000-0002-3779-4540"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harley I. Kornblum","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.92330002784729,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.92330002784729,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.03280000016093254,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma-stem-cells","display_name":"glioblastoma stem cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/nada","display_name":"Nada","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cannabinoid-receptors","display_name":"cannabinoid receptors","score":0.7020000219345093},{"id":"https://openalex.org/keywords/trpv1-receptor","display_name":"TRPV1 receptor","score":0.800000011920929},{"id":"https://openalex.org/keywords/dopamine-receptors","display_name":"dopamine receptors","score":0.8629999756813049},{"id":"https://openalex.org/keywords/receptor-antagonists","display_name":"receptor antagonists","score":0.5860000252723694},{"id":"https://openalex.org/keywords/atp-content","display_name":"ATP levels","score":0.7419999837875366},{"id":"https://openalex.org/keywords/molecular-screening","display_name":"molecular screening","score":0.41200000047683716},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6080818772315979},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5688214302062988},{"id":"https://openalex.org/C160145004","wikidata":"https://www.wikidata.org/wiki/Q413209","display_name":"TRPV1","level":4,"score":0.4737183451652527},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.45286059379577637},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.42340075969696045},{"id":"https://openalex.org/C93248783","wikidata":"https://www.wikidata.org/wiki/Q21150595","display_name":"Cannabinoid receptor type 2","level":5,"score":0.4216769337654114},{"id":"https://openalex.org/C148001335","wikidata":"https://www.wikidata.org/wiki/Q421237","display_name":"Cannabinoid receptor","level":4,"score":0.37970203161239624},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36050862073898315},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3459621071815491},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3339330554008484},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23583292961120605},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.218834787607193},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.18324953317642212},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.10147207975387573}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/1535-7163.22496724","doi":"https://doi.org/10.1158/1535-7163.22496724","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22496724","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_A_Molecular_Screening_Approach_to_Identify_and_Characterize_Inhibitors_of_Glioblastoma_Stem_Cells/22496724/1/files/39954750.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1535-7163.22496724.v1","doi":"https://doi.org/10.1158/1535-7163.22496724.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22496724.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22496724","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_A_Molecular_Screening_Approach_to_Identify_and_Characterize_Inhibitors_of_Glioblastoma_Stem_Cells/22496724","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.22496724","doi":"https://doi.org/10.1158/1535-7163.22496724","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22496724","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_A_Molecular_Screening_Approach_to_Identify_and_Characterize_Inhibitors_of_Glioblastoma_Stem_Cells/22496724/1/files/39954750.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4362525863.pdf","grobid_xml":"https://content.openalex.org/works/W4362525863.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4392687497","https://openalex.org/W7100709277","https://openalex.org/W3087346727","https://openalex.org/W4311009660","https://openalex.org/W2165921443","https://openalex.org/W2741162363","https://openalex.org/W2976951111","https://openalex.org/W2562356294","https://openalex.org/W2334697425","https://openalex.org/W1606789163"],"abstract_inverted_index":{"PDF":[0],"File":[1],"-":[2,4,21,63],"(67K)":[3],"Effects":[5],"of":[6,23,58,65,80,111],"OLDA,":[7,47,66,93],"PALDA":[8,48,67,94],"and":[9,83,99],"NADA":[10,96],"are":[11,104],"not":[12,39,87],"mediated":[13],"via":[14],"cannabinoid,":[15],"vanilloid":[16],"or":[17,35,49,68,95],"dopamine":[18],"receptors":[19,85],"A":[20],"Exposure":[22,64],"GSC":[24,70],"-enriched":[25,71],"GBM":[26,72],"157":[27,73],"cells":[28,74],"to":[29,46,78],"CB1,":[30],"CB2,":[31],"TRPV1":[32],"receptor":[33],"agonists":[34],"their":[36],"combination,":[37],"does":[38,86],"reproduce":[40],"the":[41,89,112],"phenotype":[42,90],"seen":[43],"after":[44],"exposure":[45],"NADA.":[50],"Graph":[51],"showing":[52,105],"ATP":[53,106],"level":[54],"expressed":[55,108],"as":[56,109],"%":[57,110],"DMSO":[59,113],"treated":[60,114],"controls.":[61],"B":[62],"NADA-pretreated":[69],"(at":[75],"IC50":[76],"concentration)":[77],"antagonists":[79],"CB,":[81],"TRPV":[82],"D":[84],"rescue":[88],"caused":[91],"by":[92],"(B,":[97],"C":[98],"D,":[100],"respectively).":[101],"The":[102],"graphs":[103],"levels":[107],"controls":[115],"(100%).":[116],"SE":[117],"shown.":[118]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-06T00:00:00"}