{"id":"https://openalex.org/W4362525447","doi":"https://doi.org/10.1158/2767-9764.c.6550899","title":"Data from Targeting OCT2 with Duloxetine to Prevent Oxaliplatin-induced Peripheral Neurotoxicity","display_name":"Data from Targeting OCT2 with Duloxetine to Prevent Oxaliplatin-induced Peripheral Neurotoxicity","publication_year":2023,"publication_date":"2023-04-04","ids":{"openalex":"https://openalex.org/W4362525447","doi":"https://doi.org/10.1158/2767-9764.c.6550899"},"language":"en","primary_location":{"id":"doi:10.1158/2767-9764.c.6550899","doi":"https://doi.org/10.1158/2767-9764.c.6550899","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.c.6550899","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2767-9764.c.6550899","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000853381","display_name":"Mahesh Raj Nepal","orcid":"https://orcid.org/0000-0001-7259-2699","observed_orcids":["https://orcid.org/0000-0001-7259-2699"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mahesh R. Nepal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067184440","display_name":"Hanieh Taheri","orcid":"https://orcid.org/0000-0003-3236-7870","observed_orcids":["https://orcid.org/0000-0003-3236-7870"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hanieh Taheri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100421368","display_name":"Yang Li","orcid":"https://orcid.org/0000-0001-9055-2332","observed_orcids":["https://orcid.org/0000-0001-9055-2332"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yang Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9055-2332","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101783607","display_name":"Zahra Talebi","orcid":"https://orcid.org/0000-0001-9166-5160","observed_orcids":["https://orcid.org/0000-0001-9166-5160"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zahra Talebi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046631238","display_name":"Muhammad Erfan Uddin","orcid":"https://orcid.org/0000-0002-7160-0455","observed_orcids":["https://orcid.org/0000-0002-7160-0455"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Muhammad Erfan Uddin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7160-0455","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100411405","display_name":"Yan Jin","orcid":"https://orcid.org/0000-0002-7668-4803","observed_orcids":["https://orcid.org/0000-0002-7668-4803"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Jin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044512737","display_name":"Duncan F. DiGiacomo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Duncan F. DiGiacomo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068080699","display_name":"Alice A. Gibson","orcid":"https://orcid.org/0000-0001-5910-5067","observed_orcids":["https://orcid.org/0000-0001-5910-5067"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alice A. Gibson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5910-5067","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086903918","display_name":"Maryam B. Lustberg","orcid":"https://orcid.org/0000-0001-8559-5645","observed_orcids":["https://orcid.org/0000-0001-8559-5645"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maryam B. Lustberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077955893","display_name":"Shuiying Hu","orcid":"https://orcid.org/0000-0002-9806-7734","observed_orcids":["https://orcid.org/0000-0002-9806-7734"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuiying Hu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9806-7734","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5065279964","display_name":"Alex Sparreboom","orcid":"https://orcid.org/0000-0003-2660-6644","observed_orcids":["https://orcid.org/0000-0003-2660-6644"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alex Sparreboom","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2660-6644","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.6244999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.6244999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.3521000146865845,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/duloxetine","display_name":"duloxetine","score":0.9710000157356262},{"id":"https://openalex.org/keywords/oct2","display_name":"OCT2","score":0.8640000224113464},{"id":"https://openalex.org/keywords/organic-cation-transporter-2","display_name":"organic cation transporter 2","score":0.7070000171661377},{"id":"https://openalex.org/keywords/dorsal-root-ganglion-neurons","display_name":"dorsal root ganglion neurons","score":0.9100000262260437},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.7490000128746033},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.6769999861717224},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7070000171661377},{"id":"https://openalex.org/keywords/anticancer-drug-side-effects","display_name":"anticancer drug side effects","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.9688476324081421},{"id":"https://openalex.org/C2780764818","wikidata":"https://www.wikidata.org/wiki/Q411932","display_name":"Duloxetine","level":3,"score":0.817875862121582},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6932865977287292},{"id":"https://openalex.org/C2910564767","wikidata":"https://www.wikidata.org/wiki/Q411932","display_name":"Duloxetine Hydrochloride","level":4,"score":0.6359217762947083},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.6121554374694824},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5646175742149353},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.55963134765625},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.5141199231147766},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3215067982673645},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3015132546424866},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2564903199672699},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.2326194941997528},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20507380366325378},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2006092071533203},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19603276252746582},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.17087212204933167},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07974329590797424},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2767-9764.c.6550899","doi":"https://doi.org/10.1158/2767-9764.c.6550899","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.c.6550899","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2767-9764.c.6550899","doi":"https://doi.org/10.1158/2767-9764.c.6550899","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.c.6550899","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4296823104","https://openalex.org/W4281729275","https://openalex.org/W4225673949","https://openalex.org/W3207717469","https://openalex.org/W3124126256","https://openalex.org/W3017295529","https://openalex.org/W7140296465","https://openalex.org/W3210338691","https://openalex.org/W4245530369","https://openalex.org/W2109846148"],"abstract_inverted_index":{"Oxaliplatin-induced":[0],"peripheral":[1],"neurotoxicity":[2],"(OIPN)":[3],"is":[4,16],"a":[5,118,145,175,235,306],"debilitating":[6],"side":[7,45],"effect":[8,46],"that":[9,15,51,131,255,294],"afflicts":[10],"approximately":[11],"90%":[12],"of":[13,21,99,103,111,117,126,138,151,160,191,198,219,266,274,289,297,316],"patients":[14,245],"initiated":[17],"by":[18,213,300],"OCT2-dependent":[19],"uptake":[20,195],"oxaliplatin":[22,199,267],"in":[23,42,73,83,123,144,171,183,200,204,207,244],"dorsal":[24],"root":[25],"ganglion":[26],"(DRG)":[27],"neurons.":[28,270],"The":[29,215],"antidepressant":[30],"drug":[31],"duloxetine":[32,52,100,132,157,256,277,301],"has":[33,53,257],"been":[34],"used":[35,59,95],"to":[36,63,66,96,163,174,178,309],"treat":[37],"OIPN,":[38,104],"although":[39],"its":[40,231],"usefulness":[41],"preventing":[43,242],"this":[44],"remains":[47],"unclear.":[48],"We":[49,129,253],"hypothesized":[50],"OCT2-inhibitory":[54,259],"properties":[55,218,260,288],"and":[56,82,91,108,113,149,153,168,196,206,261,286],"can":[57,262,302],"be":[58,303],"as":[60,234,305],"an":[61],"adjunct":[62],"oxaliplatin-based":[64,317],"regimens":[65],"prevent":[67],"OIPN.":[68],"Transport":[69],"studies":[70,239],"were":[71,94,209],"performed":[72],"cells":[74],"stably":[75],"transfected":[76],"with":[77,222,246,250,276],"mouse":[78,85],"or":[79],"human":[80],"OCT2":[81,106],"isolated":[84],"DRG":[86,164,269],"neurons":[87,165],"ex":[88,166],"vivo.":[89],"Wild-type":[90],"OCT2-deficient":[92,184],"mice":[93,173,275],"assess":[97],"effects":[98],"on":[101],"hallmarks":[102],"endogenous":[105],"biomarkers,":[107],"the":[109,114,135,179,188,194,223,283,314],"pharmacokinetics":[110,285],"oxaliplatin,":[112,143],"translational":[115],"feasibility":[116],"duloxetine-oxaliplatin":[119],"combination":[120],"was":[121],"evaluated":[122],"various":[124],"models":[125],"colorectal":[127],"cancer.":[128],"found":[130,254],"potently":[133],"inhibited":[134],"OCT2-mediated":[136,298],"transport":[137,299],"several":[139],"xenobiotic":[140],"substrates,":[141],"including":[142],"reversible,":[146],"concentration-dependent":[147],"manner,":[148],"independent":[150],"species":[152],"cell":[154,202],"context.":[155],"Furthermore,":[156],"restricted":[158],"access":[159],"these":[161],"substrates":[162],"vivo":[167,208],"prevented":[169,278],"OIPN":[170,243,279,311],"wild-type":[172],"degree":[176],"similar":[177],"complete":[180],"protection":[181],"observed":[182,216],"mice,":[185],"without":[186,280,312],"affecting":[187],"plasma":[189,284],"levels":[190],"oxaliplatin.":[192,251,290],"Importantly,":[193],"cytotoxicity":[197],"tumor":[201],"lines":[203],"vitro":[205],"not":[210],"negatively":[211],"influenced":[212],"duloxetine.":[214],"OCT2-targeting":[217],"duloxetine,":[220],"combined":[221],"potential":[224],"for":[225,230,238],"clinical":[226],"translation,":[227],"provide":[228],"support":[229],"further":[232],"exploration":[233],"therapeutic":[236],"candidate":[237],"aimed":[240],"at":[241],"cancer":[247],"requiring":[248],"treatment":[249],"Significance:":[252],"potent":[258],"diminish":[263],"excessive":[264],"accumulation":[265],"into":[268],"In":[271],"addition,":[272],"pretreatment":[273],"significantly":[281],"altering":[282],"antitumor":[287],"These":[291],"results":[292],"suggest":[293],"intentional":[295],"inhibition":[296],"employed":[304],"prevention":[307],"strategy":[308],"ameliorate":[310],"compromising":[313],"effectiveness":[315],"treatment.":[318]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2023-04-06T00:00:00"}