{"id":"https://openalex.org/W4362525444","doi":"https://doi.org/10.1158/2643-3230.c.6551112","title":"Data from Distinct Genetically Determined Origins of Myd88/BCL2-Driven Aggressive Lymphoma Rationalize Targeted Therapeutic Intervention Strategies","display_name":"Data from Distinct Genetically Determined Origins of Myd88/BCL2-Driven Aggressive Lymphoma Rationalize Targeted Therapeutic Intervention Strategies","publication_year":2023,"publication_date":"2023-04-04","ids":{"openalex":"https://openalex.org/W4362525444","doi":"https://doi.org/10.1158/2643-3230.c.6551112"},"language":"en","primary_location":{"id":"doi:10.1158/2643-3230.c.6551112","doi":"https://doi.org/10.1158/2643-3230.c.6551112","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2643-3230.c.6551112","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2643-3230.c.6551112","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012506836","display_name":"Ruth Fl\u00fcmann","orcid":"https://orcid.org/0000-0002-7147-7557","observed_orcids":["https://orcid.org/0000-0002-7147-7557"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruth Fl\u00fcmann","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7147-7557","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039171181","display_name":"Julia Hansen","orcid":"https://orcid.org/0000-0001-7828-1269","observed_orcids":["https://orcid.org/0000-0001-7828-1269"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julia Hansen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7828-1269","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016367718","display_name":"Benedikt W. Pelzer","orcid":"https://orcid.org/0000-0002-1892-3650","observed_orcids":["https://orcid.org/0000-0002-1892-3650"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benedikt W. Pelzer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1892-3650","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048948327","display_name":"Pascal Nieper","orcid":"https://orcid.org/0000-0003-0607-3561","observed_orcids":["https://orcid.org/0000-0003-0607-3561"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pascal Nieper","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0607-3561","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049889438","display_name":"Tim Lohmann","orcid":"https://orcid.org/0000-0002-3216-0784","observed_orcids":["https://orcid.org/0000-0002-3216-0784"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tim Lohmann","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3216-0784","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026425216","display_name":"Ilmars Kisis","orcid":"https://orcid.org/0000-0001-6207-3991","observed_orcids":["https://orcid.org/0000-0001-6207-3991"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ilmars Kisis","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6207-3991","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033924154","display_name":"Tobias Ri\u00ebt","orcid":"https://orcid.org/0000-0002-8211-7071","observed_orcids":["https://orcid.org/0000-0002-8211-7071"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tobias Riet","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8211-7071","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061725234","display_name":"Viktoria Kohlhas","orcid":"https://orcid.org/0000-0001-8133-1001","observed_orcids":["https://orcid.org/0000-0001-8133-1001"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Viktoria Kohlhas","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8133-1001","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080354347","display_name":"Phuong\u2010Hien Nguyen","orcid":"https://orcid.org/0000-0002-3249-7264","observed_orcids":["https://orcid.org/0000-0002-3249-7264"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Phuong-Hien Nguyen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3249-7264","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068488866","display_name":"Martin Peifer","orcid":"https://orcid.org/0000-0002-5243-5503","observed_orcids":["https://orcid.org/0000-0002-5243-5503"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin Peifer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5243-5503","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036973535","display_name":"Nima Abedpour","orcid":"https://orcid.org/0000-0002-2933-8035","observed_orcids":["https://orcid.org/0000-0002-2933-8035"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nima Abedpour","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2933-8035","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082867904","display_name":"Graziella Bosco","orcid":"https://orcid.org/0000-0001-6601-4518","observed_orcids":["https://orcid.org/0000-0001-6601-4518"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Graziella Bosco","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6601-4518","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058511375","display_name":"Roman Kurt Thomas","orcid":"https://orcid.org/0000-0001-9132-4876","observed_orcids":["https://orcid.org/0000-0001-9132-4876"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roman K. Thomas","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9132-4876","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026085333","display_name":"Moritz Kochanek","orcid":"https://orcid.org/0000-0001-6879-9996","observed_orcids":["https://orcid.org/0000-0001-6879-9996"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Moritz Kochanek","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6879-9996","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027437406","display_name":"Jacqueline Kn\u00fcfer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jacqueline Kn\u00fcfer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089411144","display_name":"Lorenz Jonigkeit","orcid":"https://orcid.org/0000-0003-1059-8977","observed_orcids":["https://orcid.org/0000-0003-1059-8977"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lorenz Jonigkeit","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1059-8977","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036966030","display_name":"Filippo Beleggia","orcid":"https://orcid.org/0000-0003-0234-7094","observed_orcids":["https://orcid.org/0000-0003-0234-7094"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Filippo Beleggia","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0234-7094","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002388229","display_name":"Alessandra M. E. Holzem","orcid":"https://orcid.org/0000-0002-3241-3446","observed_orcids":["https://orcid.org/0000-0002-3241-3446"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alessandra Holzem","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3241-3446","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006712577","display_name":"Reinhard B\u00fcttner","orcid":"https://orcid.org/0000-0001-8806-4786","observed_orcids":["https://orcid.org/0000-0001-8806-4786"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reinhard B\u00fcttner","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8806-4786","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003729966","display_name":"Philipp Lohneis","orcid":"https://orcid.org/0000-0002-4797-0018","observed_orcids":["https://orcid.org/0000-0002-4797-0018"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philipp Lohneis","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4797-0018","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003738338","display_name":"J\u00f6rn Meinel","orcid":"https://orcid.org/0000-0003-2224-2580","observed_orcids":["https://orcid.org/0000-0003-2224-2580"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J\u00f6rn Meinel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2224-2580","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016691886","display_name":"Monika Ortmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Monika Ortmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014839908","display_name":"Thors\ufefften Persigehl","orcid":"https://orcid.org/0000-0001-5928-4405","observed_orcids":["https://orcid.org/0000-0001-5928-4405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thorsten Persigehl","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5928-4405","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076077834","display_name":"Michael J. Hallek","orcid":"https://orcid.org/0000-0002-7425-4455","observed_orcids":["https://orcid.org/0000-0002-7425-4455"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Hallek","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7425-4455","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039656907","display_name":"Dinis Pedro Calado","orcid":"https://orcid.org/0000-0001-8239-7184","observed_orcids":["https://orcid.org/0000-0001-8239-7184"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dinis Pedro Calado","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8239-7184","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039167759","display_name":"Markus Martin Chmielewski","orcid":"https://orcid.org/0000-0001-9348-5219","observed_orcids":["https://orcid.org/0000-0001-9348-5219"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Markus Chmielewski","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9348-5219","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067129030","display_name":"Sebastian Klein","orcid":"https://orcid.org/0000-0002-2188-9377","observed_orcids":["https://orcid.org/0000-0002-2188-9377"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sebastian Klein","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2188-9377","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083112108","display_name":"Joachim Rudolf G\u00f6thert","orcid":"https://orcid.org/0000-0001-8957-6732","observed_orcids":["https://orcid.org/0000-0001-8957-6732"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joachim R. G\u00f6thert","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8957-6732","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074215180","display_name":"Bjoern Chapuy","orcid":"https://orcid.org/0000-0002-6485-8773","observed_orcids":["https://orcid.org/0000-0002-6485-8773"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bjoern Chapuy","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6485-8773","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050253682","display_name":"Branko Zevnik","orcid":"https://orcid.org/0000-0001-7845-9522","observed_orcids":["https://orcid.org/0000-0001-7845-9522"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Branko Zevnik","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7845-9522","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072937215","display_name":"Frank Thomas Wunderlich","orcid":"https://orcid.org/0000-0002-9209-3501","observed_orcids":["https://orcid.org/0000-0002-9209-3501"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Thomas Wunderlich","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9209-3501","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040054777","display_name":"Bastian von Tresckow","orcid":"https://orcid.org/0000-0003-1410-4487","observed_orcids":["https://orcid.org/0000-0003-1410-4487"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bastian von Tresckow","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1410-4487","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028710105","display_name":"Ron Daniel Jachimowicz","orcid":"https://orcid.org/0000-0001-9522-7061","observed_orcids":["https://orcid.org/0000-0001-9522-7061"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ron D. Jachimowicz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9522-7061","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019770989","display_name":"Ari M. Melnick","orcid":"https://orcid.org/0000-0002-8074-2287","observed_orcids":["https://orcid.org/0000-0002-8074-2287"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ari M. Melnick","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8074-2287","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030035319","display_name":"Hans Christian Reinhardt","orcid":"https://orcid.org/0000-0001-5706-9349","observed_orcids":["https://orcid.org/0000-0001-5706-9349"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hans Christian Reinhardt","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5706-9349","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5046660376","display_name":"Gero Knittel","orcid":"https://orcid.org/0000-0001-8395-3701","observed_orcids":["https://orcid.org/0000-0001-8395-3701"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gero Knittel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8395-3701","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.972000002861023},{"id":"https://openalex.org/keywords/myd88-mutation","display_name":"MYD88 mutation","score":0.9039999842643738},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9520000219345093},{"id":"https://openalex.org/keywords/blimp-1","display_name":"Blimp-1","score":0.871999979019165},{"id":"https://openalex.org/keywords/spib","display_name":"Spi-B","score":0.9829999804496765},{"id":"https://openalex.org/keywords/b-cell-receptor-signaling","display_name":"B cell receptor signaling","score":0.8700000047683716},{"id":"https://openalex.org/keywords/relapsed-refractory-lymphoma","display_name":"relapsed/refractory lymphoma","score":0.871999979019165},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.7720000147819519},{"id":"https://openalex.org/keywords/cd19-car-t-cell-therapy","display_name":"CD19 CAR T-cell therapy","score":0.8569999933242798},{"id":"https://openalex.org/keywords/mouse-lymphoma-model","display_name":"mouse lymphoma model","score":0.7020000219345093},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6161397099494934},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4912993311882019},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.4868735373020172},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4805879592895508},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4701445400714874},{"id":"https://openalex.org/C90059517","wikidata":"https://www.wikidata.org/wiki/Q423572","display_name":"Bruton's tyrosine kinase","level":4,"score":0.4314667582511902},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.24893394112586975},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.20530566573143005},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20433646440505981},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20391550660133362},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.137807697057724}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/2643-3230.c.6551112","doi":"https://doi.org/10.1158/2643-3230.c.6551112","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2643-3230.c.6551112","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/2643-3230.c.6551112.v1","doi":"https://doi.org/10.1158/2643-3230.c.6551112.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2643-3230.c.6551112.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2643-3230.c.6551112","doi":"https://doi.org/10.1158/2643-3230.c.6551112","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2643-3230.c.6551112","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4308554161","https://openalex.org/W4362546577","https://openalex.org/W7045593866","https://openalex.org/W7010997053","https://openalex.org/W3217656995","https://openalex.org/W4389429900","https://openalex.org/W4389736542","https://openalex.org/W4416587285","https://openalex.org/W4310125562","https://openalex.org/W2326263722"],"abstract_inverted_index":{"Abstract":[0],"Genomic":[1],"profiling":[2],"revealed":[3,184],"the":[4,18,42,95,176,216],"identity":[5],"of":[6,11,44,122,162,178,188,195],"at":[7],"least":[8],"5":[9],"subtypes":[10],"diffuse":[12],"large":[13],"B-cell":[14],"lymphoma":[15],"(DLBCL),":[16],"including":[17],"MCD/C5":[19],"cluster":[20],"characterized":[21],"by":[22,205],"aberrations":[23,40],"in":[24,105,117,120,150,198,215],"MYD88,":[25],"BCL2,":[26],"PRDM1,":[27],"and/or":[28],"SPIB.":[29],"We":[30,50,192],"generated":[31,171],"mouse":[32,172],"models":[33,183],"harboring":[34],"B":[35,73,77,100],"cell\u2013specific":[36],"Prdm1":[37],"or":[38,64],"Spib":[39],"on":[41],"background":[43],"oncogenic":[45],"Myd88":[46],"and":[47,56,75,89,119,143,160],"Bcl2":[48],"lesions.":[49],"deployed":[51],"whole-exome":[52],"sequencing,":[53],"transcriptome,":[54],"flow-cytometry,":[55],"mass":[57],"cytometry":[58],"analyses":[59],"to":[60,146,166],"demonstrate":[61,109],"that":[62,110],"Prdm1-":[63],"Spib-altered":[65],"lymphomas":[66,80,129],"display":[67],"molecular":[68],"features":[69],"consistent":[70],"with":[71,94],"prememory":[72],"cells":[74],"light-zone":[76,88],"cells,":[78],"whereas":[79],"lacking":[81],"these":[82,163],"alterations":[83],"were":[84,130,144],"enriched":[85],"for":[86,98],"late":[87],"plasmablast-associated":[90],"gene":[91],"sets.":[92],"Consistent":[93],"phenotypic":[96],"evidence":[97],"increased":[99],"cell":[101,148],"receptor":[102],"signaling":[103],"activity":[104,116,187,194],"Prdm1-altered":[106,128],"lymphomas,":[107],"we":[108,170],"combined":[111,189],"BTK/BCL2":[112,190],"inhibition":[113],"displays":[114],"therapeutic":[115],"mice":[118],"five":[121],"six":[123],"relapsed/refractory":[124],"DLBCL":[125,154],"patients.":[126,201],"Moreover,":[127],"immunogenic":[131],"upon":[132],"transplantation":[133],"into":[134],"immuno-competent":[135],"hosts,":[136],"displayed":[137],"an":[138],"actionable":[139],"PD-L1":[140],"surface":[141],"expression,":[142],"sensitive":[145],"antimurine-CD19-CAR-T":[147],"therapy,":[149],"vivo.":[151],"Significance:":[152],"Relapsed/refractory":[153],"remains":[155],"a":[156],"major":[157],"medical":[158],"challenge,":[159],"most":[161],"patients":[164],"succumb":[165],"their":[167],"disease.":[168],"Here,":[169],"models,":[173],"faithfully":[174],"recapitulating":[175],"biology":[177],"MYD88-driven":[179],"human":[180],"DLBCL.":[181],"These":[182],"robust":[185],"preclinical":[186],"inhibition.":[191],"confirmed":[193],"this":[196],"regimen":[197],"pretreated":[199],"non\u2013GCB-DLBCL":[200],"See":[202],"related":[203],"commentary":[204],"Leveille":[206],"et":[207],"al.,":[208],"p.":[209,221],"8.":[210],"This":[211,218],"article":[212],"is":[213],"highlighted":[214],"In":[217],"Issue":[219],"feature,":[220],"1":[222]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-06T00:00:00"}