{"id":"https://openalex.org/W4362525376","doi":"https://doi.org/10.1158/2326-6066.c.6550485","title":"Data from Modifications to the Framework Regions Eliminate Chimeric Antigen Receptor Tonic Signaling","display_name":"Data from Modifications to the Framework Regions Eliminate Chimeric Antigen Receptor Tonic Signaling","publication_year":2023,"publication_date":"2023-04-04","ids":{"openalex":"https://openalex.org/W4362525376","doi":"https://doi.org/10.1158/2326-6066.c.6550485"},"language":"en","primary_location":{"id":"doi:10.1158/2326-6066.c.6550485","doi":"https://doi.org/10.1158/2326-6066.c.6550485","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2326-6066.c.6550485","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/2326-6066.c.6550485","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021996903","display_name":"Elisa Landoni","orcid":"https://orcid.org/0009-0005-8450-6256","observed_orcids":["https://orcid.org/0009-0005-8450-6256"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elisa Landoni","raw_affiliation_strings":["Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000073229","display_name":"Giovanni Fuc\u00e0","orcid":"https://orcid.org/0000-0002-1560-2253","observed_orcids":["https://orcid.org/0000-0002-1560-2253"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giovanni Fuc\u00e1","raw_affiliation_strings":["Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024072185","display_name":"Jian Wang","orcid":"https://orcid.org/0000-0001-7768-2802","observed_orcids":["https://orcid.org/0000-0001-7768-2802"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian Wang","raw_affiliation_strings":["Departments of Pharmacology and Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania"],"raw_orcid":"https://orcid.org/0000-0001-7768-2802","affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087789524","display_name":"Venkat R. Chirasani","orcid":"https://orcid.org/0000-0003-1416-0438","observed_orcids":["https://orcid.org/0000-0003-1416-0438"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Venkat R. Chirasani","raw_affiliation_strings":["Departments of Pharmacology and Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010824471","display_name":"Zhiyuan Yao","orcid":"https://orcid.org/0000-0003-4812-9850","observed_orcids":["https://orcid.org/0000-0003-4812-9850"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhiyuan Yao","raw_affiliation_strings":["Depart-ment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"],"raw_orcid":"https://orcid.org/0000-0003-4812-9850","affiliations":[{"raw_affiliation_string":"Depart-ment of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015594479","display_name":"Elena Dukhovlinova","orcid":"https://orcid.org/0000-0002-2094-2543","observed_orcids":["https://orcid.org/0000-0002-2094-2543"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elena Dukhovlinova","raw_affiliation_strings":["Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028669896","display_name":"Soldano Ferrone","orcid":"https://orcid.org/0000-0003-2900-8834","observed_orcids":["https://orcid.org/0000-0003-2900-8834"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Soldano Ferrone","raw_affiliation_strings":["Department of Surgery, Massachusetts General Hospital,","Harvard Medical School, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0003-2900-8834","affiliations":[{"raw_affiliation_string":"Department of Surgery, Massachusetts General Hospital,","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065544223","display_name":"Barbara Savoldo","orcid":"https://orcid.org/0000-0002-7571-3887","observed_orcids":["https://orcid.org/0000-0002-7571-3887"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara Savoldo","raw_affiliation_strings":["Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014352382","display_name":"Lee K. Hong","orcid":"https://orcid.org/0000-0003-0002-8858","observed_orcids":["https://orcid.org/0000-0003-0002-8858"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lee K. Hong","raw_affiliation_strings":["Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058775810","display_name":"Peishun Shou","orcid":"https://orcid.org/0000-0001-7685-7471","observed_orcids":["https://orcid.org/0000-0001-7685-7471"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peishun Shou","raw_affiliation_strings":["Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"],"raw_orcid":"https://orcid.org/0000-0001-7685-7471","affiliations":[{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021928287","display_name":"Silvia Musio","orcid":"https://orcid.org/0000-0002-8051-7389","observed_orcids":["https://orcid.org/0000-0002-8051-7389"]},"institutions":[{"id":"https://openalex.org/I4210164485","display_name":"Fondazione IRCCS Istituto Neurologico Carlo Besta","ror":"https://ror.org/05rbx8m02","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210164485"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Musio","raw_affiliation_strings":["Laboratory of Immunotherapy of Brain Tumors, Unit of Molecular Neuro-Oncology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0002-8051-7389","affiliations":[{"raw_affiliation_string":"Laboratory of Immunotherapy of Brain Tumors, Unit of Molecular Neuro-Oncology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy","institution_ids":["https://openalex.org/I4210164485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080420402","display_name":"Francesco Padelli","orcid":"https://orcid.org/0000-0002-0390-7789","observed_orcids":["https://orcid.org/0000-0002-0390-7789"]},"institutions":[{"id":"https://openalex.org/I4210164485","display_name":"Fondazione IRCCS Istituto Neurologico Carlo Besta","ror":"https://ror.org/05rbx8m02","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210164485"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Padelli","raw_affiliation_strings":["Experimental Imaging and Neuro-Radiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0002-0390-7789","affiliations":[{"raw_affiliation_string":"Experimental Imaging and Neuro-Radiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy","institution_ids":["https://openalex.org/I4210164485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047711662","display_name":"Gaetano Finocchiaro","orcid":"https://orcid.org/0000-0003-3583-4040","observed_orcids":["https://orcid.org/0000-0003-3583-4040","https://orcid.org/0000-0002-3936-2151"]},"institutions":[{"id":"https://openalex.org/I4210164485","display_name":"Fondazione IRCCS Istituto Neurologico Carlo Besta","ror":"https://ror.org/05rbx8m02","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210164485"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gaetano Finocchiaro","raw_affiliation_strings":["Laboratory of Immunotherapy of Brain Tumors, Unit of Molecular Neuro-Oncology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0003-3583-4040","affiliations":[{"raw_affiliation_string":"Laboratory of Immunotherapy of Brain Tumors, Unit of Molecular Neuro-Oncology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy","institution_ids":["https://openalex.org/I4210164485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025326042","display_name":"Miriam Droste","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164280","display_name":"Cell Medica (Switzerland)","ror":"https://ror.org/05jddt560","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210120755","https://openalex.org/I4210164280"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Miriam Droste","raw_affiliation_strings":["Cell Medica Switzerland AG, Zurich-Schlieren, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Medica Switzerland AG, Zurich-Schlieren, Switzerland","institution_ids":["https://openalex.org/I4210164280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013989048","display_name":"Brian A. Kuhlman","orcid":"https://orcid.org/0000-0003-4907-9699","observed_orcids":["https://orcid.org/0000-0003-4907-9699"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Kuhlman","raw_affiliation_strings":["Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018100825","display_name":"Abdijapar T. Shamshiev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164280","display_name":"Cell Medica (Switzerland)","ror":"https://ror.org/05jddt560","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210120755","https://openalex.org/I4210164280"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Abdijapar Shamshiev","raw_affiliation_strings":["Cell Medica Switzerland AG, Zurich-Schlieren, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Medica Switzerland AG, Zurich-Schlieren, Switzerland","institution_ids":["https://openalex.org/I4210164280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036842630","display_name":"Serena Pellegatta","orcid":"https://orcid.org/0000-0001-7804-9486","observed_orcids":["https://orcid.org/0000-0001-7804-9486"]},"institutions":[{"id":"https://openalex.org/I4210164485","display_name":"Fondazione IRCCS Istituto Neurologico Carlo Besta","ror":"https://ror.org/05rbx8m02","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210164485"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Serena Pellegatta","raw_affiliation_strings":["Laboratory of Immunotherapy of Brain Tumors, Unit of Molecular Neuro-Oncology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy"],"raw_orcid":"https://orcid.org/0000-0001-7804-9486","affiliations":[{"raw_affiliation_string":"Laboratory of Immunotherapy of Brain Tumors, Unit of Molecular Neuro-Oncology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy","institution_ids":["https://openalex.org/I4210164485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033490428","display_name":"Nikolay V. Dokholyan","orcid":"https://orcid.org/0000-0002-8225-4025","observed_orcids":["https://orcid.org/0000-0002-8225-4025"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikolay V. Dokholyan","raw_affiliation_strings":["Departments of Pharmacology and Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania"],"raw_orcid":"https://orcid.org/0000-0002-8225-4025","affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023649972","display_name":"Gianpietro Dotti","orcid":"https://orcid.org/0000-0002-2639-8526","observed_orcids":["https://orcid.org/0000-0002-2639-8526"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gianpietro Dotti","raw_affiliation_strings":["Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5023649972"],"corresponding_institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chimeric-antigen-receptor","display_name":"chimeric antigen receptor","score":0.9390000104904175},{"id":"https://openalex.org/keywords/tonic-signaling","display_name":"tonic signaling","score":0.8270000219345093},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.9279999732971191},{"id":"https://openalex.org/keywords/framework-regions","display_name":"framework regions","score":0.746999979019165},{"id":"https://openalex.org/keywords/cd3","display_name":"CD3","score":0.734000027179718},{"id":"https://openalex.org/keywords/cd28-costimulation","display_name":"CD28 costimulation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/4-1bb-costimulation","display_name":"4-1BB costimulation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/humanization","display_name":"humanization","score":0.7139999866485596},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7990000247955322},{"id":"https://openalex.org/keywords/antitumor-efficacy","display_name":"antitumor efficacy","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C148125776","wikidata":"https://www.wikidata.org/wiki/Q1622348","display_name":"CD28","level":4,"score":0.5783695578575134},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.5345190167427063},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4981577396392822},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4972060024738312},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4946605861186981},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4718204438686371},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.46228671073913574},{"id":"https://openalex.org/C30278631","wikidata":"https://www.wikidata.org/wiki/Q281721","display_name":"Chimera (genetics)","level":3,"score":0.41845810413360596},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3495025932788849},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33599841594696045},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3089298605918884},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.30430108308792114},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2823859453201294},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23688137531280518},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19242224097251892}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/2326-6066.c.6550485","doi":"https://doi.org/10.1158/2326-6066.c.6550485","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2326-6066.c.6550485","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/2326-6066.c.6550485.v1","doi":"https://doi.org/10.1158/2326-6066.c.6550485.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2326-6066.c.6550485.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2326-6066.c.6550485","doi":"https://doi.org/10.1158/2326-6066.c.6550485","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2326-6066.c.6550485","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2099377632","display_name":"STRATEGIES TO COUNTERACT RESISTANCE MECHANISMS IN CAR+ T-CELL-BASED IMMUNOTHERAPY FOR TRIPLE-NEGATIVE BREAST CANCER","funder_award_id":"W81XWH1610500","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G288273860","display_name":"T cell plasticity, fusion proteins and CAR T cell-based immunotherapy of head and neck cancer","funder_award_id":"R01DE028172","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G4119534169","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G5850682332","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6505907193","display_name":"IL-15 TRiKES-based specific immunotherapy of TNBC; resistance mechanisms","funder_award_id":"R03CA216114","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7366156696","display_name":null,"funder_award_id":"CA016086","funder_id":"https://openalex.org/F4320337594","funder_display_name":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill"},{"id":"https://openalex.org/G9000033364","display_name":null,"funder_award_id":"CA016086","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000191530","display_name":null,"funder_award_id":"R01 CA193140","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000881502","display_name":"Nanoscale programming of celluar and physiological phenotypes","funder_award_id":"R35GM134864","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000886573","display_name":"Penn State Clinical and Translational Science Institute","funder_award_id":"UL1TR002014","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000898202","display_name":"Computational Design of Protein Structures and Complexes","funder_award_id":"R35GM131923","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G958207224","display_name":null,"funder_award_id":"P30-CA016086","funder_id":"https://openalex.org/F4320337594","funder_display_name":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"},{"id":"https://openalex.org/F4320337594","display_name":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W575621713","https://openalex.org/W1574443686","https://openalex.org/W1619537825","https://openalex.org/W1977949161","https://openalex.org/W1985006546","https://openalex.org/W2003197307","https://openalex.org/W2003539449","https://openalex.org/W2008992691","https://openalex.org/W2010607826","https://openalex.org/W2022228265","https://openalex.org/W2028460943","https://openalex.org/W2044154766","https://openalex.org/W2056261693","https://openalex.org/W2062793526","https://openalex.org/W2065514217","https://openalex.org/W2081298822","https://openalex.org/W2105879190","https://openalex.org/W2106892694","https://openalex.org/W2107696550","https://openalex.org/W2108257090","https://openalex.org/W2113744970","https://openalex.org/W2118780761","https://openalex.org/W2118796952","https://openalex.org/W2144491853","https://openalex.org/W2153550070","https://openalex.org/W2154543415","https://openalex.org/W2161187689","https://openalex.org/W2175144302","https://openalex.org/W2553096714","https://openalex.org/W2567498952","https://openalex.org/W2580377636","https://openalex.org/W2736784601","https://openalex.org/W2743083943","https://openalex.org/W2761657464","https://openalex.org/W2914523419","https://openalex.org/W2970465352","https://openalex.org/W2983312573","https://openalex.org/W3003185702","https://openalex.org/W4211196614","https://openalex.org/W4233454230","https://openalex.org/W4298883371"],"related_works":["https://openalex.org/W3151257693","https://openalex.org/W7110507315","https://openalex.org/W4385720584","https://openalex.org/W3202682482","https://openalex.org/W3091168849","https://openalex.org/W4404903707","https://openalex.org/W4323349483","https://openalex.org/W7000406561","https://openalex.org/W2984295746","https://openalex.org/W4409516759"],"abstract_inverted_index":{"Abstract":[0],"Chimeric":[1],"antigen":[2,121],"receptor":[3],"(CAR)":[4],"tonic":[5,36,114,135],"signaling,":[6],"defined":[7],"as":[8],"spontaneous":[9],"activation":[10],"and":[11,54,123,149],"release":[12],"of":[13,44,80,102,110,116,128,137,146,153],"proinflammatory":[14],"cytokines":[15],"by":[16,40,85,98,142],"CAR-T":[17,129,138,165],"cells,":[18],"is":[19,38,140],"considered":[20],"a":[21,70],"negative":[22],"attribute":[23],"because":[24],"it":[25],"leads":[26],"to":[27,51,159],"impaired":[28],"antitumor":[29,126],"effects.":[30],"Here,":[31],"we":[32,132],"report":[33],"that":[34,94,134,150],"CAR":[35,63,71],"signaling":[37,55,115,136],"caused":[39,84],"the":[41,45,57,62,81,90,103,111,117,125,143,147,154,161],"intrinsic":[42],"instability":[43,145,163],"mAb":[46],"single-chain":[47],"variable":[48],"fragment":[49],"(scFv)":[50],"promote":[52],"self-aggregation":[53],"via":[56],"CD3\u03b6":[58],"chain":[59],"incorporated":[60],"into":[61],"construct.":[64],"This":[65],"phenomenon":[66],"was":[67,83],"detected":[68],"in":[69,164],"encoding":[72],"either":[73,168],"CD28":[74,169],"or":[75,108,170],"4-1BB":[76,171],"costimulatory":[77],"endodomains.":[78],"Instability":[79],"scFv":[82,148,155,162],"specific":[86],"amino":[87,104],"acids":[88,105],"within":[89],"framework":[91],"regions":[92],"(FWR)":[93],"can":[95,156],"be":[96,157],"identified":[97],"computational":[99,151],"modeling.":[100],"Substitutions":[101],"causing":[106],"instability,":[107],"humanization":[109],"FWRs,":[112],"corrected":[113],"CAR,":[118],"without":[119],"modifying":[120],"specificity,":[122],"enhanced":[124],"effects":[127],"cells.":[130],"Overall,":[131],"demonstrated":[133],"cells":[139,166],"determined":[141],"molecular":[144],"analyses":[152],"implemented":[158],"correct":[160],"with":[167],"costimulation.":[172]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-06T00:00:00"}
