{"id":"https://openalex.org/W4362525242","doi":"https://doi.org/10.1158/2643-3230.c.6550641","title":"Data from Blockade or Deletion of IFN\u03b3 Reduces Macrophage Activation without Compromising CAR T-cell Function in Hematologic Malignancies","display_name":"Data from Blockade or Deletion of IFN\u03b3 Reduces Macrophage Activation without Compromising CAR T-cell Function in Hematologic Malignancies","publication_year":2023,"publication_date":"2023-04-04","ids":{"openalex":"https://openalex.org/W4362525242","doi":"https://doi.org/10.1158/2643-3230.c.6550641"},"language":"en","primary_location":{"id":"doi:10.1158/2643-3230.c.6550641","doi":"https://doi.org/10.1158/2643-3230.c.6550641","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2643-3230.c.6550641","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2643-3230.c.6550641","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083811774","display_name":"Stefanie R. Bailey","orcid":"https://orcid.org/0000-0002-1175-521X","observed_orcids":["https://orcid.org/0000-0002-1175-521X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefanie R. Bailey","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1175-521X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028007805","display_name":"Sonika Vatsa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sonika Vatsa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062214590","display_name":"Rebecca C. Larson","orcid":"https://orcid.org/0000-0003-0174-061X","observed_orcids":["https://orcid.org/0000-0003-0174-061X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rebecca C. Larson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073324722","display_name":"Amanda A. Bouffard","orcid":"https://orcid.org/0009-0003-1501-4384","observed_orcids":["https://orcid.org/0009-0003-1501-4384"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amanda A. Bouffard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029335246","display_name":"Irene Scarf\u00f2","orcid":"https://orcid.org/0000-0002-5545-3248","observed_orcids":["https://orcid.org/0000-0002-5545-3248"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Irene Scarf\u00f2","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041791638","display_name":"Michael C. Kann","orcid":"https://orcid.org/0000-0002-5917-0296","observed_orcids":["https://orcid.org/0000-0002-5917-0296"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael C. Kann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030394595","display_name":"Trisha R. Berger","orcid":"https://orcid.org/0000-0003-3439-3239","observed_orcids":["https://orcid.org/0000-0003-3439-3239"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Trisha R. Berger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012987786","display_name":"Mark B. Leick","orcid":"https://orcid.org/0000-0003-3111-0221","observed_orcids":["https://orcid.org/0000-0003-3111-0221"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark B. Leick","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3111-0221","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082229490","display_name":"Marc Wehrli","orcid":"https://orcid.org/0000-0001-7915-5862","observed_orcids":["https://orcid.org/0000-0001-7915-5862"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marc Wehrli","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7915-5862","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007761693","display_name":"Andrea Schmidts","orcid":"https://orcid.org/0000-0001-7035-1584","observed_orcids":["https://orcid.org/0000-0001-7035-1584"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrea Schmidts","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014226056","display_name":"Harrison Silva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harrison Silva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017805383","display_name":"Kevin A. Lindell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin A. Lindell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023330706","display_name":"Ashley Demato","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashley Demato","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009794322","display_name":"Kathleen Gallagher","orcid":"https://orcid.org/0009-0004-4818-2082","observed_orcids":["https://orcid.org/0009-0004-4818-2082"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kathleen M.E. Gallagher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064556004","display_name":"Matthew J. Frigault","orcid":"https://orcid.org/0000-0002-6774-5694","observed_orcids":["https://orcid.org/0000-0002-6774-5694"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew J. Frigault","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5029763484","display_name":"Marcela Valderrama Maus","orcid":"https://orcid.org/0000-0002-7578-0393","observed_orcids":["https://orcid.org/0000-0002-7578-0393"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcela V. Maus","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7578-0393","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7820000052452087},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.734000027179718},{"id":"https://openalex.org/keywords/cytokine-release-syndrome","display_name":"cytokine release syndrome","score":0.9259999990463257},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.9860000014305115},{"id":"https://openalex.org/keywords/immune-checkpoint-proteins","display_name":"immune checkpoint molecules","score":0.8259999752044678},{"id":"https://openalex.org/keywords/car-t-cell-toxicity","display_name":"CAR T-cell toxicity","score":0.6380000114440918},{"id":"https://openalex.org/keywords/lymphoma","display_name":"lymphoma","score":0.6880000233650208},{"id":"https://openalex.org/keywords/antitumor-efficacy","display_name":"antitumor efficacy","score":0.7419999837875366},{"id":"https://openalex.org/keywords/car-t-cell-proliferation","display_name":"CAR-T cell proliferation","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5657200813293457},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.560615599155426},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5585383772850037},{"id":"https://openalex.org/C2780850621","wikidata":"https://www.wikidata.org/wiki/Q3961647","display_name":"Cytokine release syndrome","level":5,"score":0.5428711175918579},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5351516008377075},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5036877989768982},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4929022789001465},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.48503750562667847},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.46493077278137207},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39202699065208435},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36573782563209534},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35926732420921326},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.34500616788864136},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.23195591568946838},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1609078049659729}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2643-3230.c.6550641","doi":"https://doi.org/10.1158/2643-3230.c.6550641","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2643-3230.c.6550641","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2643-3230.c.6550641","doi":"https://doi.org/10.1158/2643-3230.c.6550641","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2643-3230.c.6550641","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4200078655","https://openalex.org/W3215925233","https://openalex.org/W3102999061","https://openalex.org/W7117147123","https://openalex.org/W4409626672","https://openalex.org/W4380079346","https://openalex.org/W7221619042","https://openalex.org/W4415764405","https://openalex.org/W4407977136","https://openalex.org/W2917856590"],"abstract_inverted_index":{"Abstract":[0],"Chimeric":[1],"antigen":[2],"receptor":[3],"(CAR)":[4],"T":[5,30,46,158],"cells":[6,31,108,159,168],"induce":[7],"impressive":[8],"responses":[9,53],"in":[10,51,54,86,89,106,156,198,235],"patients":[11,115],"with":[12,76,116,181,203],"hematologic":[13,55,84,137,166,199],"malignancies":[14,56,85],"but":[15],"can":[16],"also":[17],"trigger":[18],"cytokine":[19,104],"release":[20],"syndrome":[21],"(CRS),":[22],"a":[23,41,98],"systemic":[24],"toxicity":[25,197],"caused":[26],"by":[27,224],"activated":[28],"CAR":[29,45,117,133,157,191],"and":[32,112,139,150,169,174,178],"innate":[33],"immune":[34,72,107],"cells.":[35],"Although":[36],"IFN\u03b3":[37,70,92,128,141,155,187],"production":[38],"serves":[39],"as":[40],"potency":[42],"assay":[43],"for":[44,132,216],"cells,":[47],"its":[48],"biologic":[49],"role":[50],"conferring":[52],"is":[57,129,233],"not":[58,130,161],"established.":[59],"Here":[60],"we":[61],"show":[62,126],"that":[63,127,186],"pharmacologic":[64],"blockade":[65,93,188],"or":[66,88],"genetic":[67],"knockout":[68],"of":[69,209],"reduced":[71,94],"checkpoint":[73],"protein":[74],"expression":[75],"no":[77],"detrimental":[78],"effect":[79],"on":[80],"antitumor":[81,151],"efficacy":[82,135],"against":[83,136,165],"vitro":[87],"vivo.":[90],"Furthermore,":[91],"macrophage":[95],"activation":[96],"to":[97],"greater":[99],"extent":[100],"than":[101],"currently":[102],"used":[103],"antagonists":[105],"from":[109,114],"healthy":[110],"donors":[111],"serum":[113],"T-cell\u2013treated":[118],"lymphoma":[119],"who":[120],"developed":[121],"CRS.":[122,182],"Collectively,":[123],"these":[124],"data":[125],"required":[131],"T-cell":[134,192],"malignancies,":[138],"blocking":[140],"could":[142],"simultaneously":[143],"mitigate":[144],"cytokine-related":[145],"toxicities":[146],"while":[147,194],"preserving":[148],"persistence":[149],"efficacy.":[152],"Significance:":[153],"Blocking":[154],"does":[160],"impair":[162],"their":[163,172],"cytotoxicity":[164],"tumor":[167],"paradoxically":[170],"enhances":[171],"proliferation":[173],"reduces":[175],"macrophage-mediated":[176],"cytokines":[177],"chemokines":[179],"associated":[180],"These":[183],"findings":[184],"suggest":[185],"may":[189],"improve":[190],"function":[193],"reducing":[195],"treatment-related":[196],"malignancies.":[200],"See":[201,221],"interview":[202],"Stefanie":[204],"R.":[205],"Bailey,":[206],"PhD,":[207],"recipient":[208],"the":[210,236],"2023":[211],"Blood":[212],"Cancer":[213],"Discovery":[214],"Award":[215],"Outstanding":[217],"Journal":[218],"Article:":[219],"https://vimeo.com/847433865":[220],"related":[222],"content":[223],"McNerney":[225],"et":[226],"al.,":[227],"p.":[228,241],"90":[229],"(17).":[230],"This":[231,238],"article":[232],"highlighted":[234],"In":[237],"Issue":[239],"feature,":[240],"85":[242]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2023-04-06T00:00:00"}
