{"id":"https://openalex.org/W4362525185","doi":"https://doi.org/10.1158/2326-6066.c.6550566","title":"Data from Loss of LRRC33-Dependent TGF\u03b21 Activation Enhances Antitumor Immunity and Checkpoint Blockade Therapy","display_name":"Data from Loss of LRRC33-Dependent TGF\u03b21 Activation Enhances Antitumor Immunity and Checkpoint Blockade Therapy","publication_year":2023,"publication_date":"2023-04-04","ids":{"openalex":"https://openalex.org/W4362525185","doi":"https://doi.org/10.1158/2326-6066.c.6550566"},"language":"en","primary_location":{"id":"doi:10.1158/2326-6066.c.6550566","doi":"https://doi.org/10.1158/2326-6066.c.6550566","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.c.6550566","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2326-6066.c.6550566","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038007498","display_name":"Aiping Jiang","orcid":"https://orcid.org/0000-0002-8389-2950","observed_orcids":["https://orcid.org/0000-0002-8389-2950"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aiping Jiang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8389-2950","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100510256","display_name":"Qin Yan","orcid":"https://orcid.org/0009-0001-7857-2653","observed_orcids":["https://orcid.org/0009-0001-7857-2653"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Qin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5003615852","display_name":"Timothy A. Springer","orcid":"https://orcid.org/0000-0001-6627-2904","observed_orcids":["https://orcid.org/0000-0001-6627-2904"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy A. Springer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6627-2904","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.014299999922513962,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-infiltrating-myeloid-cells","display_name":"tumor-infiltrating myeloid cells","score":0.8690000176429749},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.925000011920929},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.7689999938011169},{"id":"https://openalex.org/keywords/pd-1-pd-l1-blockade","display_name":"PD-1/PD-L1 blockade","score":0.9559999704360962},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.9739999771118164},{"id":"https://openalex.org/keywords/m1-macrophages","display_name":"M1 macrophages","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.875},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-immunogenicity","display_name":"tumor immunogenicity","score":0.6119999885559082},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8090000152587891},{"id":"https://openalex.org/keywords/b16f10-melanoma","display_name":"B16F10 melanoma","score":0.8539999723434448}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6765754222869873},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.6226617097854614},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.5917702317237854},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5602251291275024},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5551175475120544},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5513305068016052},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.5262538194656372},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.41984888911247253},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40720564126968384},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38313066959381104},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.37594789266586304},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36212486028671265},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35442304611206055},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.24002817273139954},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.15225699543952942},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.054444819688797}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2326-6066.c.6550566","doi":"https://doi.org/10.1158/2326-6066.c.6550566","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.c.6550566","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2326-6066.c.6550566","doi":"https://doi.org/10.1158/2326-6066.c.6550566","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.c.6550566","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4212785863","https://openalex.org/W4414533432","https://openalex.org/W2931391344","https://openalex.org/W2782207381","https://openalex.org/W2602612283","https://openalex.org/W2792146488","https://openalex.org/W4308399179","https://openalex.org/W4392689690","https://openalex.org/W4385783664","https://openalex.org/W4392723007"],"abstract_inverted_index":{"Abstract":[0],"TGF\u03b2":[1,17,21,29],"has":[2],"multiple":[3,85],"roles":[4],"and":[5,10,51,53,59,75,80,107,110,119,138,150],"gene":[6],"products":[7],"(TGF\u03b21,":[8],"-\u03b22,":[9],"-\u03b23),":[11],"which":[12,27],"make":[13],"global":[14],"targeting":[15],"of":[16,20,33,61,68,133,143,146],"undesirable.":[18],"Expression":[19],"requires":[22],"association":[23],"with":[24,47,98],"milieu":[25],"molecules,":[26],"localize":[28],"to":[30],"the":[31,131,140,147],"surface":[32,57],"specific":[34],"cells":[35],"or":[36],"extracellular":[37],"matrices.":[38],"Here,":[39],"we":[40],"found":[41],"that":[42],"LRRC33":[43,90,117,134],"was":[44,54],"specifically":[45],"associated":[46],"TGF\u03b21,":[48],"not":[49],"TGF\u03b22":[50],"TGF\u03b23,":[52],"required":[55],"for":[56],"display":[58],"activation":[60,71],"TGF\u03b21":[62,70],"on":[63],"tumor-infiltrating":[64],"myeloid":[65],"cells.":[66],"Loss":[67],"LRRC33-dependent":[69],"slowed":[72],"tumor":[73,88,126,136],"growth":[74],"metastasis":[76],"by":[77],"enhancing":[78],"innate":[79],"adaptive":[81],"antitumor":[82],"immunity":[83],"in":[84,93,123,135,152],"mouse":[86],"syngeneic":[87],"models.":[89],"loss":[91,118],"resulted":[92],"a":[94],"more":[95,103,111],"immunogenic":[96],"microenvironment,":[97],"decreased":[99],"myeloid-derived":[100],"suppressor":[101],"cells,":[102,109],"active":[104],"CD8+":[105],"T":[106],"NK":[108],"skewing":[112],"toward":[113],"tumor-suppressive":[114],"M1":[115],"macrophages.":[116],"PD-1":[120],"blockade":[121,145],"synergized":[122],"controlling":[124],"B16.F10":[125],"growth.":[127],"Our":[128],"results":[129],"demonstrate":[130],"importance":[132],"biology":[137],"highlight":[139],"therapeutic":[141],"potential":[142],"dual":[144],"LRRC33/TGF\u03b21":[148],"axis":[149],"PD-1/PD-L1":[151],"cancer":[153],"immunotherapy.":[154]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2023-04-06T00:00:00"}
