{"id":"https://openalex.org/W4362525167","doi":"https://doi.org/10.1158/2326-6066.c.6550071","title":"Data from STING Signaling in Melanoma Cells Shapes Antigenicity and Can Promote Antitumor T-cell Activity","display_name":"Data from STING Signaling in Melanoma Cells Shapes Antigenicity and Can Promote Antitumor T-cell Activity","publication_year":2023,"publication_date":"2023-04-04","ids":{"openalex":"https://openalex.org/W4362525167","doi":"https://doi.org/10.1158/2326-6066.c.6550071"},"language":"en","primary_location":{"id":"doi:10.1158/2326-6066.c.6550071","doi":"https://doi.org/10.1158/2326-6066.c.6550071","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2326-6066.c.6550071","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/2326-6066.c.6550071","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057006257","display_name":"Rana Falahat","orcid":"https://orcid.org/0000-0001-7489-3807","observed_orcids":["https://orcid.org/0000-0001-7489-3807"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rana Falahat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082896599","display_name":"Patricio Perez-Villarroel","orcid":"https://orcid.org/0000-0003-1997-5994","observed_orcids":["https://orcid.org/0000-0003-1997-5994"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patricio Perez-Villarroel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003759306","display_name":"Adam William Mailloux","orcid":"https://orcid.org/0000-0002-4563-6489","observed_orcids":["https://orcid.org/0000-0002-4563-6489"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adam W. Mailloux","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036699887","display_name":"Genyuan Zhu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Genyuan Zhu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006278901","display_name":"Shari Pilon\u2010Thomas","orcid":"https://orcid.org/0000-0001-7785-3034","observed_orcids":["https://orcid.org/0000-0001-7785-3034"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shari Pilon-Thomas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050436106","display_name":"Glen N. Barber","orcid":"https://orcid.org/0000-0002-4703-0931","observed_orcids":["https://orcid.org/0000-0002-4703-0931"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Glen N. Barber","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5004554374","display_name":"James J. Mul\u00e9","orcid":"https://orcid.org/0000-0001-7354-0516","observed_orcids":["https://orcid.org/0000-0001-7354-0516"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James J. Mul\u00e9","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7354-0516","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.8065999746322632,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.8065999746322632,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.10080000013113022,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.08749999850988388,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sting-signaling","display_name":"STING signaling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/tumor-antigenicity","display_name":"tumor antigenicity","score":0.828000009059906},{"id":"https://openalex.org/keywords/mhc-class-i-expression","display_name":"MHC class I expression","score":0.9139999747276306},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.9909999966621399},{"id":"https://openalex.org/keywords/antitumor-t-cell-responses","display_name":"antitumor T-cell responses","score":0.8569999933242798},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.9100000262260437},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.6320000290870667},{"id":"https://openalex.org/keywords/tumor-cell-intrinsic-signaling","display_name":"tumor cell-intrinsic signaling","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C2779026604","wikidata":"https://www.wikidata.org/wiki/Q4774742","display_name":"Antigenicity","level":3,"score":0.7119909524917603},{"id":"https://openalex.org/C2779300339","wikidata":"https://www.wikidata.org/wiki/Q7617409","display_name":"Sting","level":2,"score":0.6942722797393799},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.637498140335083},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5945392847061157},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5688644647598267},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5333577990531921},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.49892687797546387},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.49519816040992737},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.48988717794418335},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.48269009590148926},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.39555594325065613},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.31259047985076904},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2326-6066.c.6550071","doi":"https://doi.org/10.1158/2326-6066.c.6550071","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2326-6066.c.6550071","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2326-6066.c.6550071","doi":"https://doi.org/10.1158/2326-6066.c.6550071","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2326-6066.c.6550071","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2970843395","https://openalex.org/W4409636103","https://openalex.org/W3152326806","https://openalex.org/W4415898735","https://openalex.org/W3106357129","https://openalex.org/W4361823898","https://openalex.org/W4353087862","https://openalex.org/W2525369565","https://openalex.org/W2492602760","https://openalex.org/W2892055986"],"abstract_inverted_index":{"Abstract":[0],"STING":[1,42,56,72,108,138],"(stimulator":[2],"of":[3,14,39,55,61,71,77,99],"IFN":[4],"genes)":[5],"signaling":[6,43,57,73,109,139],"is":[7],"an":[8],"innate":[9],"immune":[10,116,145],"pathway":[11,110],"for":[12],"induction":[13],"a":[15,59,75],"spontaneous":[16],"antitumor":[17],"T-cell":[18],"response":[19],"against":[20],"certain":[21],"immunogenic":[22],"tumors.":[23],"Although":[24],"antigen-presenting":[25],"cells":[26,113],"are":[27],"known":[28],"to":[29,88,124,150],"be":[30],"involved":[31],"in":[32,52,74,106,135],"this":[33,47],"process,":[34],"insight":[35],"into":[36],"the":[37,53,97,107],"participation":[38],"tumor":[40,136,144],"cell\u2013intrinsic":[41,137],"remains":[44],"weak.":[45],"In":[46],"study,":[48],"we":[49,131],"find":[50],"diversity":[51],"regulation":[54],"across":[58],"panel":[60],"human":[62,78,91],"melanoma":[63,79,92,112],"cell":[64,80],"lines.":[65],"We":[66],"show":[67],"that":[68,133],"intact":[69],"activation":[70],"subset":[76],"lines":[81],"enhances":[82],"both":[83],"their":[84,122],"antigenicity":[85],"and":[86,120],"susceptibility":[87],"lysis":[89],"by":[90,118],"tumor-infiltrating":[93],"lymphocytes":[94],"(TIL)":[95],"through":[96],"augmentation":[98],"MHC":[100],"class":[101],"I":[102],"expression.":[103],"Conversely,":[104],"defects":[105,134],"protect":[111],"from":[114],"increased":[115],"recognition":[117],"TILs":[119],"limit":[121],"sensitivity":[123],"TIL":[125],"lysis.":[126],"Based":[127],"on":[128],"these":[129],"findings,":[130],"propose":[132],"can":[140],"mediate":[141],"not":[142],"only":[143],"evasion":[146],"but":[147],"also":[148],"resistance":[149],"TIL-based":[151],"immunotherapies.":[152]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-04-06T00:00:00"}