{"id":"https://openalex.org/W4362525012","doi":"https://doi.org/10.1158/2643-3230.c.6550173","title":"Data from Large-scale Identification of Clonal Hematopoiesis and Mutations Recurrent in Blood Cancers","display_name":"Data from Large-scale Identification of Clonal Hematopoiesis and Mutations Recurrent in Blood Cancers","publication_year":2023,"publication_date":"2023-04-04","ids":{"openalex":"https://openalex.org/W4362525012","doi":"https://doi.org/10.1158/2643-3230.c.6550173"},"language":"en","primary_location":{"id":"doi:10.1158/2643-3230.c.6550173","doi":"https://doi.org/10.1158/2643-3230.c.6550173","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2643-3230.c.6550173","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2643-3230.c.6550173","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088414680","display_name":"Julie Ellen Feusier","orcid":"https://orcid.org/0000-0002-1266-087X","observed_orcids":["https://orcid.org/0000-0002-1266-087X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julie E. Feusier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104263143","display_name":"Sasi Arunachalam","orcid":"https://orcid.org/0000-0002-5282-9377","observed_orcids":["https://orcid.org/0000-0002-5282-9377"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sasi Arunachalam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065547046","display_name":"Tsewang Tashi","orcid":"https://orcid.org/0000-0002-2785-866X","observed_orcids":["https://orcid.org/0000-0002-2785-866X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tsewang Tashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006120003","display_name":"Monika J. Baker","orcid":"https://orcid.org/0000-0002-7430-7588","observed_orcids":["https://orcid.org/0000-0002-7430-7588"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Monika J. Baker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050556235","display_name":"Chad Hilton Vansant-Webb","orcid":"https://orcid.org/0000-0001-8478-9317","observed_orcids":["https://orcid.org/0000-0001-8478-9317"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chad VanSant-Webb","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026743400","display_name":"Amber Ferdig","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amber Ferdig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077351974","display_name":"Bryan E. Welm","orcid":"https://orcid.org/0000-0002-1879-6612","observed_orcids":["https://orcid.org/0000-0002-1879-6612"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bryan E. Welm","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059808119","display_name":"Juan L. Rodr\u00edguez-Flores","orcid":"https://orcid.org/0000-0002-0394-8062","observed_orcids":["https://orcid.org/0000-0002-0394-8062"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juan L. Rodriguez-Flores","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0394-8062","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031117002","display_name":"Christopher Ours","orcid":"https://orcid.org/0000-0002-7831-1621","observed_orcids":["https://orcid.org/0000-0002-7831-1621"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher Ours","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090698697","display_name":"Lynn B. Jorde","orcid":"https://orcid.org/0000-0002-0606-1862","observed_orcids":["https://orcid.org/0000-0002-0606-1862"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lynn B. Jorde","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042381475","display_name":"Josef T. Prchal","orcid":"https://orcid.org/0000-0002-8019-2940","observed_orcids":["https://orcid.org/0000-0002-8019-2940"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Josef T. Prchal","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8019-2940","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5055616906","display_name":"Clinton C. Mason","orcid":"https://orcid.org/0000-0002-9566-4568","observed_orcids":["https://orcid.org/0000-0002-9566-4568"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Clinton C. Mason","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9566-4568","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clonal-hematopoiesis-of-indeterminate-potential","display_name":"clonal hematopoiesis of indeterminate potential","score":0.9980000257492065},{"id":"https://openalex.org/keywords/clonal-mutations","display_name":"clonal mutations","score":0.7870000004768372},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.7770000100135803},{"id":"https://openalex.org/keywords/mutation-hotspots","display_name":"mutational hotspots","score":0.8330000042915344},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.7459999918937683},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.9819999933242798},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.4740000069141388},{"id":"https://openalex.org/keywords/cancer-risk","display_name":"cancer risk","score":0.6060000061988831},{"id":"https://openalex.org/keywords/whole-exome-sequencing","display_name":"exome sequencing","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.6744507551193237},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5512583255767822},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.5452895164489746},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4973657429218292},{"id":"https://openalex.org/C10590036","wikidata":"https://www.wikidata.org/wiki/Q417664","display_name":"Exome","level":5,"score":0.49171262979507446},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4736429750919342},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4465769827365875},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.44512319564819336},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.43637433648109436},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4355001151561737},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.4145034849643707},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40310418605804443},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38766250014305115},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36555224657058716},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34087079763412476}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2643-3230.c.6550173","doi":"https://doi.org/10.1158/2643-3230.c.6550173","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2643-3230.c.6550173","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2643-3230.c.6550173","doi":"https://doi.org/10.1158/2643-3230.c.6550173","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2643-3230.c.6550173","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.800000011920929,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3134287629","https://openalex.org/W4410814418","https://openalex.org/W4234443265","https://openalex.org/W4200482041","https://openalex.org/W3016191191","https://openalex.org/W7157951142","https://openalex.org/W6977670193","https://openalex.org/W4214507730","https://openalex.org/W3032714376","https://openalex.org/W2789900003"],"abstract_inverted_index":{"Abstract":[0],"Clonal":[1],"hematopoiesis":[2],"of":[3,19,39,49,63,75,91,112,131,192],"indeterminate":[4],"potential":[5,200],"(CHIP)":[6],"is":[7],"characterized":[8],"by":[9,33,208],"detectable":[10],"hematopoietic-associated":[11],"gene":[12],"mutations":[13,28,46,115,134,160,184],"in":[14,136,178,188],"a":[15,35,189],"person":[16],"without":[17],"evidence":[18],"hematologic":[20,59,168],"malignancy.":[21,60],"We":[22,84,106,181],"sought":[23],"to":[24,99,117,125,142],"identify":[25],"additional":[26,88],"cancer-presenting":[27],"usable":[29],"for":[30,82,103,149,174,201],"CHIP":[31,113,133,144],"detection":[32,145],"performing":[34],"data":[36,94],"mining":[37],"analysis":[38,90],"48":[40],"somatic":[41],"mutation":[42,72,123],"landscape":[43],"studies":[44],"reporting":[45],"at":[47,78,120,185],"diagnoses":[48],"7,430":[50],"adult":[51],"and":[52,128,146,152,170,210],"pediatric":[53],"patients":[54],"with":[55,114],"leukemia":[56],"or":[57],"other":[58],"Following":[61],"extraction":[62],"20,141":[64],"protein-altering":[65],"mutations,":[66],"we":[67],"identified":[68],"434":[69],"significantly":[70],"recurrent":[71],"hotspots,":[73],"364":[74],"which":[76],"occurred":[77,135],"loci":[79],"confidently":[80],"assessable":[81],"CHIP.":[83],"then":[85],"performed":[86],"an":[87],"large-scale":[89],"whole-exome":[92],"sequencing":[93],"from":[95,194],"4,538":[96],"persons":[97],"belonging":[98],"three":[100],"noncancer":[101,195],"cohorts":[102],"clonal":[104,183],"mutations.":[105],"found":[107],"the":[108],"combined":[109],"cohort":[110],"prevalence":[111],"identical":[116],"those":[118],"reported":[119],"blood":[121,163],"cancer":[122,175],"hotspots":[124,187],"be":[126],"1.8%,":[127],"that":[129,165],"some":[130],"these":[132,186],"children.":[137],"Our":[138],"findings":[139],"may":[140,166],"help":[141],"improve":[143],"precancer":[147,203],"surveillance":[148],"both":[150],"children":[151],"adults.":[153],"Significance:":[154],"This":[155],"study":[156],"identifies":[157],"frequently":[158],"occurring":[159],"across":[161],"several":[162],"cancers":[164],"drive":[167],"malignancies":[169],"signal":[171],"increased":[172],"risk":[173],"when":[176],"detected":[177],"healthy":[179],"persons.":[180],"find":[182],"substantial":[190],"number":[191],"individuals":[193],"cohorts,":[196],"including":[197],"children,":[198],"showcasing":[199],"improved":[202],"surveillance.":[204],"See":[205],"related":[206],"commentary":[207],"Spitzer":[209],"Levine,":[211],"p.":[212],"192.":[213]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-04-06T00:00:00"}
