{"id":"https://openalex.org/W4362495355","doi":"https://doi.org/10.1158/1535-7163.c.6536601","title":"Data from An Autocrine Loop between TGF-\u03b21 and the Transcription Factor Brachyury Controls the Transition of Human Carcinoma Cells into a Mesenchymal Phenotype","display_name":"Data from An Autocrine Loop between TGF-\u03b21 and the Transcription Factor Brachyury Controls the Transition of Human Carcinoma Cells into a Mesenchymal Phenotype","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362495355","doi":"https://doi.org/10.1158/1535-7163.c.6536601"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.c.6536601","doi":"https://doi.org/10.1158/1535-7163.c.6536601","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6536601","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1535-7163.c.6536601","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062766083","display_name":"Cecilia A. Larocca","orcid":"https://orcid.org/0000-0002-6756-261X","observed_orcids":["https://orcid.org/0000-0002-6756-261X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cecilia Larocca","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064960085","display_name":"Joseph R. Cohen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph R. Cohen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103538909","display_name":"Romaine Ingrid Fernando","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Romaine I. Fernando","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Bruce Huang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruce Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070191245","display_name":"Duane H. Hamilton","orcid":"https://orcid.org/0000-0002-9730-8209","observed_orcids":["https://orcid.org/0000-0002-9730-8209"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Duane H. Hamilton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5081826448","display_name":"Claudia Palena","orcid":"https://orcid.org/0000-0002-0445-4486","observed_orcids":["https://orcid.org/0000-0002-0445-4486"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claudia Palena","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.03999999910593033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brachyury","display_name":"Brachyury","score":0.8679999709129333},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9660000205039978},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9800000190734863},{"id":"https://openalex.org/keywords/autocrine-loop","display_name":"autocrine loop","score":0.7179999947547913},{"id":"https://openalex.org/keywords/t-box-transcription-factor","display_name":"T-box transcription factor","score":0.8009999990463257},{"id":"https://openalex.org/keywords/mesenchymal-epithelial-transition","display_name":"mesenchymal-epithelial transition","score":0.9549999833106995},{"id":"https://openalex.org/keywords/chemosensitivity","display_name":"chemosensitivity","score":0.796999990940094},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6309999823570251},{"id":"https://openalex.org/keywords/tgf-beta-inhibitors","display_name":"TGF-\u03b2 inhibitors","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C46122727","wikidata":"https://www.wikidata.org/wiki/Q14885879","display_name":"Brachyury","level":5,"score":0.963533341884613},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.6981914043426514},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6594676971435547},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.5476018190383911},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4989011287689209},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4873281419277191},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4446328282356262},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4412890076637268},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.4299634099006653},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.4262075424194336},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4204457402229309},{"id":"https://openalex.org/C2778229498","wikidata":"https://www.wikidata.org/wiki/Q24785672","display_name":"Transforming growth factor beta","level":3,"score":0.41035425662994385},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3560468554496765},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3526168465614319},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.33448904752731323},{"id":"https://openalex.org/C2780915607","wikidata":"https://www.wikidata.org/wiki/Q323438","display_name":"Mesoderm","level":4,"score":0.13265669345855713},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12118962407112122},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.09949609637260437},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08002492785453796},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05682551860809326}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1535-7163.c.6536601","doi":"https://doi.org/10.1158/1535-7163.c.6536601","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6536601","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1535-7163.c.6536601.v1","doi":"https://doi.org/10.1158/1535-7163.c.6536601.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6536601.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.c.6536601","doi":"https://doi.org/10.1158/1535-7163.c.6536601","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6536601","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2102124205","https://openalex.org/W2043979562","https://openalex.org/W2346608779","https://openalex.org/W2901221147","https://openalex.org/W2313266955","https://openalex.org/W1985947761","https://openalex.org/W4361961291","https://openalex.org/W2167479335","https://openalex.org/W4234824732","https://openalex.org/W2185479911"],"abstract_inverted_index":{"Abstract":[0],"The":[1,91],"epithelial\u2013mesenchymal":[2],"transition":[3],"(EMT)":[4],"is":[5,35,101,118,133],"a":[6,63,80,114,169,181],"process":[7],"associated":[8],"with":[9,18,209],"the":[10,19,43,55,95,141,152,156,198],"metastasis":[11],"of":[12,21,30,45,70,138,151,158,161,165,172,201],"solid":[13],"tumors":[14],"as":[15,17,67],"well":[16],"acquisition":[20],"resistance":[22],"to":[23,41,135,190],"standard":[24],"anticancer":[25,211],"modalities.":[26],"A":[27],"major":[28],"initiator":[29],"EMT":[31,56,105],"in":[32,73,106,124,155,207],"carcinoma":[33,75],"cells":[34,187],"TGF-\u03b2,":[36],"which":[37],"has":[38,88,195],"been":[39,89],"shown":[40,134],"induce":[42],"expression":[44,100],"several":[46],"transcription":[47,65],"factors":[48],"ultimately":[49],"responsible":[50],"for":[51,94,197],"initiating":[52],"and":[53,85,112,122,143,184],"maintaining":[54],"program.":[57],"We":[58],"have":[59],"previously":[60],"identified":[61],"Brachyury,":[62],"T-box":[64],"factor,":[66],"an":[68,146],"inducer":[69],"mesenchymal":[71],"features":[72],"human":[74,108],"cells.":[76,127],"In":[77,128],"this":[78,129],"study,":[79],"potential":[81],"link":[82],"between":[83,120],"Brachyury":[84,99,121,131,178],"TGF-\u03b2":[86,173,205],"signaling":[87,167],"investigated.":[90],"results":[92],"show":[93],"first":[96],"time":[97],"that":[98,113],"enhanced":[102],"during":[103],"TGF-\u03b21\u2013induced":[104],"various":[107],"cancer":[109,186],"cell":[110],"lines,":[111],"positive":[115],"feedback":[116],"loop":[117],"established":[119],"TGF-\u03b21":[123,139,153,166],"mesenchymal-like":[125],"tumor":[126],"context,":[130],"overexpression":[132],"promote":[136],"upregulation":[137],"at":[140],"mRNA":[142],"protein":[144],"levels,":[145],"effect":[147],"mediated":[148],"by":[149,168],"activation":[150],"promoter":[154],"presence":[157],"high":[159],"levels":[160],"Brachyury.":[162],"Furthermore,":[163],"inhibition":[164],"small-molecule":[170],"inhibitor":[171],"receptor":[174],"type":[175],"I":[176],"decreases":[177],"expression,":[179],"induces":[180],"mesenchymal-to-epithelial":[182],"transition,":[183],"renders":[185],"more":[188],"susceptible":[189],"chemotherapy.":[191],"This":[192],"study":[193],"thus":[194],"implications":[196],"future":[199],"development":[200],"clinical":[202],"trials":[203],"using":[204],"inhibitors":[206],"combination":[208],"other":[210],"agents.":[212],"Mol":[213],"Cancer":[214],"Ther;":[215],"12(9);":[216],"1805\u201315.":[217],"\u00a92013":[218],"AACR.":[219]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}