{"id":"https://openalex.org/W4362494599","doi":"https://doi.org/10.1158/1535-7163.22504383","title":"Supplementary Tables S1-S3 and Figures S1-S11 from Potent Dual BET Bromodomain-Kinase Inhibitors as Value-Added Multitargeted Chemical Probes and Cancer Therapeutics","display_name":"Supplementary Tables S1-S3 and Figures S1-S11 from Potent Dual BET Bromodomain-Kinase Inhibitors as Value-Added Multitargeted Chemical Probes and Cancer Therapeutics","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362494599","doi":"https://doi.org/10.1158/1535-7163.22504383"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.22504383","doi":"https://doi.org/10.1158/1535-7163.22504383","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22504383","pdf_url":"https://aacr.figshare.com/ndownloader/files/39964092","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/ndownloader/files/39964092","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072503883","display_name":"S.W. Ember","orcid":"https://orcid.org/0009-0004-6051-4625","observed_orcids":["https://orcid.org/0009-0004-6051-4625"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stuart W. Ember","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015343580","display_name":"Que T. Lambert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Que T. Lambert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032252707","display_name":"Norbert Berndt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Norbert Berndt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087134189","display_name":"Steven Gunawan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven Gunawan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008138011","display_name":"Muhammad Ayaz","orcid":"https://orcid.org/0000-0002-4299-2445","observed_orcids":["https://orcid.org/0000-0002-4299-2445","https://orcid.org/0009-0002-2021-3735"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Muhammad Ayaz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017977483","display_name":"Marilena Tauro","orcid":"https://orcid.org/0000-0003-2361-7364","observed_orcids":["https://orcid.org/0000-0003-2361-7364"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marilena Tauro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041357428","display_name":"Jin\u2010Yi Zhu","orcid":"https://orcid.org/0000-0001-5436-4262","observed_orcids":["https://orcid.org/0000-0001-5436-4262"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jin-Yi Zhu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068660492","display_name":"Paula J. C. Cranfill","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paula J. Cranfill","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088889740","display_name":"Patricia Greninger","orcid":"https://orcid.org/0000-0001-9110-7695","observed_orcids":["https://orcid.org/0000-0001-9110-7695"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patricia Greninger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005942374","display_name":"Conor C. Lynch","orcid":"https://orcid.org/0000-0002-4506-6244","observed_orcids":["https://orcid.org/0000-0002-4506-6244"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Conor C. Lynch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060699951","display_name":"Cyril H. Benes","orcid":"https://orcid.org/0000-0002-8751-9707","observed_orcids":["https://orcid.org/0000-0002-8751-9707"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cyril H. Benes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057921101","display_name":"Harshani R. Lawrence","orcid":"https://orcid.org/0000-0002-9263-7775","observed_orcids":["https://orcid.org/0000-0002-9263-7775"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harshani R. Lawrence","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060816904","display_name":"Gary W. Reuther","orcid":"https://orcid.org/0000-0002-2317-931X","observed_orcids":["https://orcid.org/0000-0002-2317-931X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary W. Reuther","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027503793","display_name":"Nicholas J. Lawrence","orcid":"https://orcid.org/0000-0003-1129-2558","observed_orcids":["https://orcid.org/0000-0003-1129-2558"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicholas J. Lawrence","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5024223427","display_name":"E. Sch\u00f6nbrunn","orcid":"https://orcid.org/0000-0002-3589-3510","observed_orcids":["https://orcid.org/0000-0002-3589-3510"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ernst Sch\u00f6nbrunn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bet-inhibitors","display_name":"BET inhibitors","score":0.8610000014305115},{"id":"https://openalex.org/keywords/brd4","display_name":"BRD4","score":0.9110000133514404},{"id":"https://openalex.org/keywords/jq1","display_name":"JQ1","score":0.7379999756813049},{"id":"https://openalex.org/keywords/kinome-profiling","display_name":"kinome profiling","score":0.8090000152587891},{"id":"https://openalex.org/keywords/crystallography","display_name":"crystallography","score":0.4959999918937683},{"id":"https://openalex.org/keywords/mm-1s-cells","display_name":"MM.1S cells","score":0.8019999861717224},{"id":"https://openalex.org/keywords/mv4-11-cells","display_name":"MV4-11 cells","score":0.9350000023841858},{"id":"https://openalex.org/keywords/ruxolitinib","display_name":"ruxolitinib","score":0.8370000123977661},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.7670000195503235},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9879999756813049},{"id":"https://openalex.org/keywords/stat3-phosphorylation","display_name":"STAT3 phosphorylation","score":0.8029999732971191},{"id":"https://openalex.org/keywords/cancer-therapeutics","display_name":"cancer therapeutics","score":0.6140000224113464},{"id":"https://openalex.org/keywords/chemical-probes","display_name":"chemical probes","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C74401373","wikidata":"https://www.wikidata.org/wiki/Q1829843","display_name":"Bromodomain","level":4,"score":0.7644989490509033},{"id":"https://openalex.org/C54174078","wikidata":"https://www.wikidata.org/wiki/Q3197188","display_name":"Kinome","level":3,"score":0.5773559808731079},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5091492533683777},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.44484972953796387},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.41565656661987305},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.386918842792511},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2733299732208252},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2563415765762329},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.11449933052062988},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0910511314868927}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.22504383","doi":"https://doi.org/10.1158/1535-7163.22504383","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22504383","pdf_url":"https://aacr.figshare.com/ndownloader/files/39964092","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.22504383","doi":"https://doi.org/10.1158/1535-7163.22504383","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22504383","pdf_url":"https://aacr.figshare.com/ndownloader/files/39964092","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6299999952316284,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4362494599.pdf","grobid_xml":"https://content.openalex.org/works/W4362494599.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2599917498","https://openalex.org/W4362494912","https://openalex.org/W1982033297","https://openalex.org/W2955921074","https://openalex.org/W3210641718","https://openalex.org/W3206614397","https://openalex.org/W2619826284","https://openalex.org/W2750537303","https://openalex.org/W2183853308","https://openalex.org/W2549779868"],"abstract_inverted_index":{"Table":[0,8,16],"S1:":[1,22],"Crystallographic":[2],"data":[3,20,61,71],"collection":[4],"and":[5,39,104],"refinement":[6],"statistics":[7],"S2:":[9,34],"Inhibitory":[10],"activity":[11],"against":[12],"other":[13,48],"BET":[14],"bromodomains":[15],"S3:":[17,44],"Bromodomain":[18],"profiling":[19,60],"Fig.":[21,33,43,54,66,75,87,97,110,123,134],"Detailed":[23],"binding":[24],"interactions":[25],"of":[26,36,47,58,72,90,102,113,127],"compounds":[27,49],"1":[28],"-":[29],"5":[30],"in":[31,41,51,107],"BRD4-1":[32],"Comparison":[35],"compound":[37],"2":[38],"JQ1":[40],"Brd4-1":[42],"Chemical":[45],"structures":[46],"used":[50],"this":[52],"work.":[53],"S4:":[55],"Statistical":[56],"evaluation":[57],"kinome":[59],"using":[62],"the":[63],"Gini":[64],"coefficient":[65],"S5:":[67],"Original":[68],"flow":[69],"cytometry":[70],"MM1.S":[73,77,108],"cells":[74,78,129],"S6:":[76],"require":[79],"stimulation":[80],"with":[81,131],"IL-6":[82],"to":[83],"detect":[84],"phospho-STAT3":[85],"levels":[86,106],"S7:":[88],"Effect":[89,112],"dual":[91,114],"BRD4-kinase":[92],"inhibitors":[93,116],"on":[94,117],"MV-4-11":[95],"cells.":[96,109],"S8:":[98],"Time":[99],"dependent":[100],"alteration":[101],"c-Myc":[103],"p21Cip1":[105],"S9:":[111],"BET-kinase":[115],"ruxolitinib":[118],"sensitive":[119],"MPN":[120],"cell":[121],"lines":[122],"S10:":[124],"Dose-effect":[125],"analysis":[126],"UKE-1":[128],"treated":[130],"drug":[132],"combinations":[133],"S11:":[135],"Cell":[136],"line":[137],"sensitivity":[138],"by":[139],"tissue":[140],"type":[141]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2023-04-05T00:00:00"}
