{"id":"https://openalex.org/W4362494511","doi":"https://doi.org/10.1158/1535-7163.22504557","title":"Table S2 from Metabolite Profiling Reveals the Glutathione Biosynthetic Pathway as a Therapeutic Target in Triple-Negative Breast Cancer","display_name":"Table S2 from Metabolite Profiling Reveals the Glutathione Biosynthetic Pathway as a Therapeutic Target in Triple-Negative Breast Cancer","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362494511","doi":"https://doi.org/10.1158/1535-7163.22504557"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.22504557","doi":"https://doi.org/10.1158/1535-7163.22504557","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22504557","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1535-7163.22504557","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090301723","display_name":"Alexander Beatty","orcid":"https://orcid.org/0000-0002-6054-4064","observed_orcids":["https://orcid.org/0000-0002-6054-4064"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Beatty","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062583319","display_name":"Lauren S. Fink","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lauren S. Fink","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010636901","display_name":"Tanu Singh","orcid":"https://orcid.org/0000-0002-0388-0758","observed_orcids":["https://orcid.org/0000-0002-0388-0758"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tanu Singh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082515406","display_name":"Alexander Strigun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Strigun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103730750","display_name":"Erik Peter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erik Peter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004849325","display_name":"Christina M. Ferrer","orcid":"https://orcid.org/0009-0006-8651-9154","observed_orcids":["https://orcid.org/0009-0006-8651-9154"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christina M. Ferrer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055625894","display_name":"\u00c9mmanuelle Nicolas","orcid":"https://orcid.org/0000-0002-0368-3519","observed_orcids":["https://orcid.org/0000-0002-0368-3519"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emmanuelle Nicolas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079001775","display_name":"Kathy Qi Cai","orcid":"https://orcid.org/0000-0002-6034-3377","observed_orcids":["https://orcid.org/0000-0002-6034-3377"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kathy Q. Cai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032891625","display_name":"Timothy P. Moran","orcid":"https://orcid.org/0000-0002-6832-9772","observed_orcids":["https://orcid.org/0000-0002-6832-9772"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy P. Moran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013346680","display_name":"Mauricio J. Reginato","orcid":"https://orcid.org/0000-0002-7541-4094","observed_orcids":["https://orcid.org/0000-0002-7541-4094"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mauricio J. Reginato","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031592853","display_name":"Ulrike E.E. Rennefahrt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ulrike Rennefahrt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5030579510","display_name":"Jeffrey R. Peterson","orcid":"https://orcid.org/0000-0002-0604-718X","observed_orcids":["https://orcid.org/0000-0002-0604-718X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey R. Peterson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.7973999977111816,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.7973999977111816,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.03519999980926514,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.03200000151991844,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutathione-synthesis","display_name":"glutathione synthesis","score":0.9520000219345093},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9559999704360962},{"id":"https://openalex.org/keywords/metabolic-profiling","display_name":"metabolite profiling","score":0.9629999995231628},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.7747848033905029},{"id":"https://openalex.org/C2994400308","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolite profiling","level":3,"score":0.6861796975135803},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.6501616835594177},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6004130840301514},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.5455282926559448},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4476564824581146},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.4170716106891632},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4153320789337158},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37123748660087585},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3558914363384247},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.336908221244812},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3170466125011444},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2519495487213135},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1363849937915802},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.13046839833259583},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0799846351146698},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.22504557","doi":"https://doi.org/10.1158/1535-7163.22504557","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22504557","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.22504557","doi":"https://doi.org/10.1158/1535-7163.22504557","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22504557","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4362494526","https://openalex.org/W4362494539","https://openalex.org/W2344977475","https://openalex.org/W2395008282","https://openalex.org/W4362494510","https://openalex.org/W2761134785","https://openalex.org/W2563720283","https://openalex.org/W1222539615","https://openalex.org/W6958527339","https://openalex.org/W3106793781"],"abstract_inverted_index":{"Table":[0],"S2.":[1],"Principal":[2],"component":[3],"analysis":[4],"loadings":[5],"for":[6],"plots":[7],"shown":[8],"in":[9],"Figure":[10,13],"1C":[11],"and":[12],"1D,":[14],"included":[15],"as":[16],"separate":[17],"Excel":[18],"file.":[19]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-04-05T00:00:00"}