{"id":"https://openalex.org/W4362493971","doi":"https://doi.org/10.1158/1535-7163.22500096","title":"Supplementary Figures 1 through 6 from Chloroquine Targets Pancreatic Cancer Stem Cells via Inhibition of CXCR4 and Hedgehog Signaling","display_name":"Supplementary Figures 1 through 6 from Chloroquine Targets Pancreatic Cancer Stem Cells via Inhibition of CXCR4 and Hedgehog Signaling","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362493971","doi":"https://doi.org/10.1158/1535-7163.22500096"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.22500096","doi":"https://doi.org/10.1158/1535-7163.22500096","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22500096","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1535-7163.22500096","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080784515","display_name":"Anamaria Balic","orcid":"https://orcid.org/0000-0001-6796-1197","observed_orcids":["https://orcid.org/0000-0001-6796-1197"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anamaria Balic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021687758","display_name":"Morten Dr\u00e6by S\u00f8rensen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Morten Dr\u00e6by S\u00f8rensen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052457337","display_name":"Sara Maria David Trabulo","orcid":"https://orcid.org/0000-0002-3178-2119","observed_orcids":["https://orcid.org/0000-0002-3178-2119"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sara Maria Trabulo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031406092","display_name":"Bruno S\u00e1inz","orcid":"https://orcid.org/0000-0003-4829-7651","observed_orcids":["https://orcid.org/0000-0003-4829-7651"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruno Sainz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075654305","display_name":"Michele Cioffi","orcid":"https://orcid.org/0000-0003-4180-5369","observed_orcids":["https://orcid.org/0000-0003-4180-5369"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michele Cioffi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113369248","display_name":"Catarina Reis Vieira","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Catarina R. Vieira","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018016887","display_name":"Irene Miranda\u2010Lorenzo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Irene Miranda-Lorenzo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086660695","display_name":"Manuel M. Hidalgo","orcid":"https://orcid.org/0000-0002-3765-3318","observed_orcids":["https://orcid.org/0000-0002-3765-3318"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manuel Hidalgo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Joerg Kleeff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joerg Kleeff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015386151","display_name":"Mert Erkan","orcid":"https://orcid.org/0000-0002-2753-0234","observed_orcids":["https://orcid.org/0000-0002-2753-0234"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mert Erkan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5058816620","display_name":"Christopher Heeschen","orcid":"https://orcid.org/0000-0002-1158-8554","observed_orcids":["https://orcid.org/0000-0002-1158-8554"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher Heeschen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.34549999237060547,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.34549999237060547,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.3246999979019165,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.2460000067949295,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chloroquine","display_name":"chloroquine","score":1.0},{"id":"https://openalex.org/keywords/pancreatic-cancer-stem-cells","display_name":"pancreatic cancer stem cells","score":0.871999979019165},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cxcr4","display_name":"CXCR4","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hedgehog-signaling","display_name":"Hedgehog signaling","score":0.9020000100135803},{"id":"https://openalex.org/keywords/sonic-hedgehog-signaling","display_name":"Sonic hedgehog signaling","score":0.8199999928474426},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.8560000061988831},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.8080000281333923},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.6639999747276306},{"id":"https://openalex.org/keywords/cancer-stem-cell-targeting","display_name":"cancer stem cell targeting","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C2777425658","wikidata":"https://www.wikidata.org/wiki/Q422438","display_name":"Chloroquine","level":3,"score":0.8380118608474731},{"id":"https://openalex.org/C129470790","wikidata":"https://www.wikidata.org/wiki/Q415718","display_name":"CXCR4","level":4,"score":0.6357131004333496},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5854344964027405},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.5659663081169128},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.5633047819137573},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5437967777252197},{"id":"https://openalex.org/C2778539099","wikidata":"https://www.wikidata.org/wiki/Q6120","display_name":"Hedgehog","level":3,"score":0.5322007536888123},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5137184858322144},{"id":"https://openalex.org/C2776637008","wikidata":"https://www.wikidata.org/wiki/Q14860072","display_name":"Sonic hedgehog","level":3,"score":0.49155959486961365},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.46329793334007263},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4540548622608185},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.4332959055900574},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.409013569355011},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3921242654323578},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36058205366134644},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32589107751846313},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.28072303533554077},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.24328744411468506},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23964324593544006},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21023344993591309},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.13163059949874878},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.1217687726020813},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0892280638217926},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.0},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/1535-7163.22500096","doi":"https://doi.org/10.1158/1535-7163.22500096","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22500096","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1535-7163.22500096.v1","doi":"https://doi.org/10.1158/1535-7163.22500096.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22500096.v1","pdf_url":"https://aacr.figshare.com/ndownloader/files/39959373","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22500096","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figures_1_through_6_from_Chloroquine_Targets_Pancreatic_Cancer_Stem_Cells_via_Inhibition_of_CXCR4_and_Hedgehog_Signaling/22500096","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.22500096","doi":"https://doi.org/10.1158/1535-7163.22500096","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22500096","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4362493971.pdf","grobid_xml":"https://content.openalex.org/works/W4362493971.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7099397338","https://openalex.org/W4362493063","https://openalex.org/W1977153130","https://openalex.org/W2187748631","https://openalex.org/W7144983269","https://openalex.org/W2000712714","https://openalex.org/W3179329273","https://openalex.org/W3030145271","https://openalex.org/W4297536010","https://openalex.org/W2055479629"],"abstract_inverted_index":{"PDF":[0],"-":[1,47],"3180K,":[2],"Figure":[3,12,20,34,45,58],"S1.":[4],"Chloroquine":[5,14,36,48],"does":[6],"not":[7,24],"affect":[8],"differentiated":[9],"cancer":[10,17],"cells.":[11,19,33],"S2.":[13],"eliminates":[15],"pancreatic":[16],"stem":[18],"S3.":[21],"Autophagy":[22],"is":[23],"mediating":[25],"the":[26,55,73],"effect":[27,39,53,63],"of":[28,43,64,72],"chloroquine":[29,65],"on":[30,40,54,66],"primary":[31],"PDAC":[32],"S4.":[35],"has":[37],"no":[38],"cell":[41],"migration":[42],"non-CSCs":[44],"S5":[46],"displays":[49],"negative":[50],"in":[51,61],"vitro":[52],"Shh":[56],"signaling.":[57],"S6.":[59],"Inhibitory":[60],"vivo":[62],"stromal":[67],"hedgehog":[68],"signaling":[69],"and":[70],"expansion":[71],"stroma.":[74]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-04-05T00:00:00"}
