{"id":"https://openalex.org/W4362493739","doi":"https://doi.org/10.1158/1535-7163.c.6538723","title":"Data from NQO1-Mediated Tumor-Selective Lethality and Radiosensitization for Head and Neck Cancer","display_name":"Data from NQO1-Mediated Tumor-Selective Lethality and Radiosensitization for Head and Neck Cancer","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362493739","doi":"https://doi.org/10.1158/1535-7163.c.6538723"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.c.6538723","doi":"https://doi.org/10.1158/1535-7163.c.6538723","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6538723","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1535-7163.c.6538723","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041704230","display_name":"Long-Shan Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Long-Shan Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Srilakshmi Reddy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Srilakshmi Reddy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101690704","display_name":"Zhenhua Lin","orcid":"https://orcid.org/0000-0002-5633-2907","observed_orcids":["https://orcid.org/0000-0002-5633-2907"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhen-Hua Lin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039815644","display_name":"Shuangping Liu","orcid":"https://orcid.org/0000-0001-6029-3245","observed_orcids":["https://orcid.org/0000-0001-6029-3245"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuangping Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023786506","display_name":"Hyunsil Park","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hyunsil Park","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012745900","display_name":"Stephen G. Chun","orcid":"https://orcid.org/0000-0002-4324-8044","observed_orcids":["https://orcid.org/0000-0002-4324-8044"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen G. Chun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105789795","display_name":"William G. Bornmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William G. Bornmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074139393","display_name":"Joel D. Thibodeaux","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joel Thibodeaux","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114045838","display_name":"Jingsheng Yan","orcid":"https://orcid.org/0000-0002-3856-8019","observed_orcids":["https://orcid.org/0000-0002-3856-8019"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jingsheng Yan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085285744","display_name":"Gaurab Chakrabarti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gaurab Chakrabarti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101198644","display_name":"Xian-Jin Xie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xian-Jin Xie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000204424","display_name":"Baran D. Sumer","orcid":"https://orcid.org/0000-0002-8371-4388","observed_orcids":["https://orcid.org/0000-0002-8371-4388"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Baran D. Sumer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016606481","display_name":"David A. Boothman","orcid":"https://orcid.org/0000-0001-7474-9020","observed_orcids":["https://orcid.org/0000-0001-7474-9020"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David A. Boothman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068474532","display_name":"John S. Yordy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John S. Yordy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nqo1","display_name":"NQO1","score":0.9819999933242798},{"id":"https://openalex.org/keywords/nad-p-h-quinone-oxidoreductase-1","display_name":"NAD(P)H:quinone oxidoreductase 1","score":0.9309999942779541},{"id":"https://openalex.org/keywords/beta-lapachone","display_name":"\u03b2-lapachone","score":0.9449999928474426},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.8799999952316284},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.9750000238418579},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.9700000286102295},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9959999918937683},{"id":"https://openalex.org/keywords/necroptosis","display_name":"necroptosis","score":0.9610000252723694},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.6880000233650208},{"id":"https://openalex.org/keywords/biomarker-guided-therapy","display_name":"biomarker-guided therapy","score":0.6169999837875366},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.5559999942779541},{"id":"https://openalex.org/keywords/nad-depletion","display_name":"NAD+ depletion","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6835195422172546},{"id":"https://openalex.org/C2778502085","wikidata":"https://www.wikidata.org/wiki/Q7662767","display_name":"Synthetic lethality","level":4,"score":0.5908718705177307},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5410228371620178},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5201654434204102},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.46504485607147217},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4617239832878113},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4579552412033081},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4563186764717102},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.42053407430648804},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37613537907600403},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.3424661159515381},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2995968759059906},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.14984235167503357},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13426217436790466},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11165586113929749},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0808035135269165}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1535-7163.c.6538723","doi":"https://doi.org/10.1158/1535-7163.c.6538723","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6538723","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1535-7163.c.6538723.v1","doi":"https://doi.org/10.1158/1535-7163.c.6538723.v1","is_oa":true,"landing_page_url":"http://doi.org/10.1158/1535-7163.c.6538723.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.c.6538723","doi":"https://doi.org/10.1158/1535-7163.c.6538723","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6538723","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2336123209","https://openalex.org/W2321986047","https://openalex.org/W1974742690","https://openalex.org/W2909437688","https://openalex.org/W4361955132","https://openalex.org/W2026604822","https://openalex.org/W2147495392","https://openalex.org/W1140549219","https://openalex.org/W3006113063","https://openalex.org/W2054253259"],"abstract_inverted_index":{"Abstract":[0],"Ionizing":[1],"radiation":[2],"(IR)":[3],"is":[4,26,33,39],"a":[5,47,73,194,201],"key":[6],"therapeutic":[7,31,75],"regimen":[8],"for":[9,22,138],"many":[10,42],"head":[11],"and":[12,29,44,92,108,125,133,135,141,155,170,173,179],"neck":[13],"cancers":[14],"(HNC).":[15],"However,":[16],"the":[17,86,100],"5-year":[18],"overall":[19],"survival":[20,147,181],"rate":[21],"locally":[23],"advanced":[24],"HNCs":[25,114,192],"approximately":[27],"50%":[28],"better":[30],"efficacy":[32,87,178],"needed.":[34],"NAD(P)H:quinone":[35],"oxidoreductase":[36],"1":[37],"(NQO1)":[38],"overexpressed":[40],"in":[41,77,105,175,182],"cancers,":[43],"\u03b2-lapachone":[45],"(\u03b2-lap),":[46],"unique":[48],"NQO1":[49,104,117,131,206],"bioactivatable":[50],"drug,":[51],"exploits":[52],"this":[53],"enzyme":[54],"to":[55,66,80,98,208,212],"release":[56],"massive":[57],"reactive":[58],"oxygen":[59],"species":[60],"(ROS)":[61],"that":[62,83],"synergize":[63],"with":[64],"IR":[65,156],"kill":[67],"by":[68,143],"programmed":[69],"necrosis.":[70],"\u03b2-Lap":[71],"represents":[72],"novel":[74],"opportunity":[76],"HNC":[78,106,122,186],"leading":[79],"tumor-selective":[81],"lethality":[82,140],"will":[84],"enhance":[85],"of":[88,103,112,130,151,191],"IR.":[89],"Immunohistochemical":[90],"staining":[91],"Western":[93],"blot":[94],"assays":[95],"were":[96,136],"used":[97],"assess":[99],"expression":[101,132,207],"levels":[102,129],"cells":[107],"tumors.":[109],"Forty-five":[110],"percent":[111],"endogenous":[113],"expressed":[115],"elevated":[116,128],"levels.":[118],"In":[119],"addition,":[120],"multiple":[121],"cell":[123,161],"lines":[124],"tumors":[126,210],"demonstrated":[127],"activity":[134],"tested":[137],"anticancer":[139],"radiosensitization":[142,190],"\u03b2-lap":[144,153,189],"using":[145,205],"long-term":[146],"assays.":[148],"The":[149],"combination":[150],"nontoxic":[152],"doses":[154],"significantly":[157],"enhanced":[158],"NQO1-dependent":[159,195],"tumor":[160],"lethality,":[162],"increased":[163],"ROS,":[164],"TUNEL-positive":[165],"cells,":[166],"DNA":[167],"damage,":[168],"NAD+,":[169],"ATP":[171],"consumption,":[172],"resulted":[174],"significant":[176],"antitumor":[177],"prolonged":[180],"two":[183],"xenograft":[184],"murine":[185],"models,":[187],"demonstrating":[188],"through":[193],"mechanism.":[196],"This":[197],"translational":[198],"study":[199],"offers":[200],"potential":[202],"biomarker-driven":[203],"strategy":[204],"select":[209],"susceptible":[211],"\u03b2-lap\u2013induced":[213],"radiosensitization.":[214],"Mol":[215],"Cancer":[216],"Ther;":[217],"15(7);":[218],"1757\u201367.":[219],"\u00a92016":[220],"AACR.":[221]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}