{"id":"https://openalex.org/W4362493433","doi":"https://doi.org/10.1158/1535-7163.c.6538788","title":"Data from A Novel Glycogen Synthase Kinase-3 Inhibitor Optimized for Acute Myeloid Leukemia Differentiation Activity","display_name":"Data from A Novel Glycogen Synthase Kinase-3 Inhibitor Optimized for Acute Myeloid Leukemia Differentiation Activity","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362493433","doi":"https://doi.org/10.1158/1535-7163.c.6538788"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.c.6538788","doi":"https://doi.org/10.1158/1535-7163.c.6538788","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6538788","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1535-7163.c.6538788","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Sophia Hu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sophia Hu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101925569","display_name":"Masumi Ueda","orcid":"https://orcid.org/0000-0003-2277-1976","observed_orcids":["https://orcid.org/0000-0003-2277-1976"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masumi Ueda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030099017","display_name":"Lindsay C. Stetson","orcid":"https://orcid.org/0000-0002-4061-3261","observed_orcids":["https://orcid.org/0000-0002-4061-3261"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lindsay Stetson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012867231","display_name":"James John Ignatz-Hoover","orcid":"https://orcid.org/0000-0001-8196-2655","observed_orcids":["https://orcid.org/0000-0001-8196-2655"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Ignatz-Hoover","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019594240","display_name":"Stephen A. Moreton","orcid":"https://orcid.org/0000-0003-1918-800X","observed_orcids":["https://orcid.org/0000-0003-1918-800X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen Moreton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Amit Chakrabarti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amit Chakrabarti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Zhiqiang Xia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhiqiang Xia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003491964","display_name":"Goutam Karan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Goutam Karan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034264716","display_name":"Marcos J. G. De Lima","orcid":"https://orcid.org/0000-0002-8568-4522","observed_orcids":["https://orcid.org/0000-0002-8568-4522"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcos de Lima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040707039","display_name":"Mukesh Agrawal","orcid":"https://orcid.org/0000-0003-4747-9533","observed_orcids":["https://orcid.org/0000-0003-4747-9533"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mukesh K. Agrawal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5005791561","display_name":"David N. Wald","orcid":"https://orcid.org/0000-0002-8695-1178","observed_orcids":["https://orcid.org/0000-0002-8695-1178"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David N. Wald","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.016499999910593033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycogen-synthase-kinase-3","display_name":"glycogen synthase kinase-3","score":0.9300000071525574},{"id":"https://openalex.org/keywords/gsk-3-inhibitors","display_name":"GSK-3 inhibitors","score":0.902999997138977},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9869999885559082},{"id":"https://openalex.org/keywords/kinase-specificity","display_name":"kinase specificity","score":0.6119999885559082},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9959999918937683},{"id":"https://openalex.org/keywords/all-trans-retinoic-acid","display_name":"all-trans retinoic acid","score":0.8190000057220459},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.7171241044998169},{"id":"https://openalex.org/C182996813","wikidata":"https://www.wikidata.org/wiki/Q910847","display_name":"GSK-3","level":3,"score":0.7077182531356812},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.6961602568626404},{"id":"https://openalex.org/C2776601000","wikidata":"https://www.wikidata.org/wiki/Q612108","display_name":"Acute promyelocytic leukemia","level":4,"score":0.689312756061554},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6660058498382568},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5786644220352173},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4682912230491638},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.46516114473342896},{"id":"https://openalex.org/C41650920","wikidata":"https://www.wikidata.org/wiki/Q14912399","display_name":"CD135","level":4,"score":0.4431532323360443},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4063456356525421},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39711248874664307},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3969705104827881},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3759377896785736},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3596562147140503},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.30603647232055664},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.1775946021080017},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.16212481260299683},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.1431668996810913},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1535-7163.c.6538788","doi":"https://doi.org/10.1158/1535-7163.c.6538788","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6538788","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1535-7163.c.6538788.v1","doi":"https://doi.org/10.1158/1535-7163.c.6538788.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6538788.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.c.6538788","doi":"https://doi.org/10.1158/1535-7163.c.6538788","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6538788","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2388625588","https://openalex.org/W2559715817","https://openalex.org/W4241237045","https://openalex.org/W1968904120","https://openalex.org/W1992861698","https://openalex.org/W2924873869","https://openalex.org/W2574828325","https://openalex.org/W2728963004","https://openalex.org/W3009605512","https://openalex.org/W2790098035"],"abstract_inverted_index":{"Abstract":[0],"Standard":[1],"therapies":[2],"used":[3],"for":[4,137,219],"the":[5,31,44,91,120],"treatment":[6],"of":[7,33,38,47,57,96,122],"acute":[8,59],"myeloid":[9],"leukemia":[10],"(AML)":[11],"are":[12],"cytotoxic":[13],"agents":[14],"that":[15],"target":[16,82],"rapidly":[17],"proliferating":[18],"cells.":[19,98,185],"Unfortunately,":[20,99],"this":[21],"therapeutic":[22,81,213],"approach":[23],"has":[24,75],"limited":[25],"efficacy":[26,166],"and":[27,30,93,173],"significant":[28],"toxicity":[29],"majority":[32],"AML":[34,49,84,114,138,147,170,176],"patients":[35],"still":[36],"die":[37],"their":[39],"disease.":[40],"In":[41],"contrast":[42],"to":[43,90,104,133,145],"poor":[45],"prognosis":[46],"most":[48,51],"patients,":[50],"individuals":[52],"with":[53,160,202,212],"a":[54,80,123,168,208,216],"rare":[55],"subtype":[56],"AML,":[58],"promyelocytic":[60],"leukemia,":[61],"can":[62,88],"be":[63],"cured":[64],"by":[65,190],"differentiation":[66,92,106,115,139,189,217],"therapy":[67],"using":[68],"regimens":[69],"containing":[70],"all-trans":[71],"retinoic":[72],"acid.":[73],"GSK3":[74,101,125,135,157,204,210],"been":[76],"previously":[77],"identified":[78],"as":[79,112,158,200,215],"in":[83,131,155,167],"where":[85],"its":[86,152],"inhibition":[87,136],"lead":[89,103],"growth":[94],"arrest":[95],"leukemic":[97],"existing":[100],"inhibitors":[102],"suboptimal":[105],"activity":[107],"making":[108],"them":[109],"less":[110],"useful":[111],"clinical":[113],"agents.":[116],"Here,":[117],"we":[118],"describe":[119],"discovery":[121],"novel":[124,209],"inhibitor,":[126],"GS87.":[127],"GS87":[128,163,186,206],"was":[129],"discovered":[130],"efforts":[132],"optimize":[134],"activity.":[140],"Despite":[141],"GS87's":[142],"dramatic":[143],"ability":[144],"induce":[146],"differentiation,":[148],"kinase":[149],"profiling":[150],"reveals":[151],"high":[153,165],"specificity":[154],"targeting":[156],"compared":[159,201],"other":[161,203],"kinases.":[162],"demonstrates":[164],"mouse":[169],"model":[171],"system":[172],"unlike":[174],"current":[175],"therapeutics,":[177],"exhibits":[178],"little":[179],"effect":[180],"on":[181],"normal":[182],"bone":[183],"marrow":[184],"induces":[187],"potent":[188],"more":[191],"effectively":[192],"activating":[193],"GSK3-dependent":[194],"signaling":[195,199],"components":[196],"including":[197],"MAPK":[198],"inhibitors.":[205],"is":[207],"inhibitor":[211],"potential":[214],"agent":[218],"non-promyelocytic":[220],"AML.":[221],"Mol":[222],"Cancer":[223],"Ther;":[224],"15(7);":[225],"1485\u201394.":[226],"\u00a92016":[227],"AACR.":[228]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}