{"id":"https://openalex.org/W4362492494","doi":"https://doi.org/10.1158/1541-7786.22517619","title":"Supplementary Figure 2 from \u03b1-Catulin Marks the Invasion Front of Squamous Cell Carcinoma and Is Important for Tumor Cell Metastasis","display_name":"Supplementary Figure 2 from \u03b1-Catulin Marks the Invasion Front of Squamous Cell Carcinoma and Is Important for Tumor Cell Metastasis","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362492494","doi":"https://doi.org/10.1158/1541-7786.22517619"},"language":"en","primary_location":{"id":"doi:10.1158/1541-7786.22517619","doi":"https://doi.org/10.1158/1541-7786.22517619","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1541-7786.22517619","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_-Catulin_Marks_the_Invasion_Front_of_Squamous_Cell_Carcinoma_and_Is_Important_for_Tumor_Cell_Metastasis/22517619/1/files/39980214.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_-Catulin_Marks_the_Invasion_Front_of_Squamous_Cell_Carcinoma_and_Is_Important_for_Tumor_Cell_Metastasis/22517619/1/files/39980214.pdf","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051115285","display_name":"Christine Do Cao","orcid":"https://orcid.org/0000-0002-1617-0149","observed_orcids":["https://orcid.org/0000-0002-1617-0149"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine Cao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066183857","display_name":"Yibu Chen","orcid":"https://orcid.org/0000-0002-7889-6850","observed_orcids":["https://orcid.org/0000-0002-7889-6850"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yibu Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103282741","display_name":"Rizwan Masood","orcid":"https://orcid.org/0000-0002-0855-4871","observed_orcids":["https://orcid.org/0000-0002-0855-4871"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rizwan Masood","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102752174","display_name":"Uttam K. Sinha","orcid":"https://orcid.org/0000-0003-4208-8904","observed_orcids":["https://orcid.org/0000-0003-4208-8904"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Uttam K. Sinha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5001535983","display_name":"Agnieszka Kobielak","orcid":"https://orcid.org/0000-0002-9293-0787","observed_orcids":["https://orcid.org/0000-0002-9293-0787"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agnieszka Kobielak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.8184000253677368,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.8184000253677368,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.13199999928474426,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.9459999799728394},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.6349999904632568},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9549999833106995},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.9160000085830688},{"id":"https://openalex.org/keywords/gene-knockdown","display_name":"gene knockdown","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9309999942779541},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.7480000257492065},{"id":"https://openalex.org/keywords/invasive-front","display_name":"invasion front","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.6154583096504211},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5829358100891113},{"id":"https://openalex.org/C190232843","wikidata":"https://www.wikidata.org/wiki/Q1950808","display_name":"Small hairpin RNA","level":4,"score":0.5491651296615601},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5425508618354797},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.531563937664032},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.52032470703125},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5072874426841736},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5033461451530457},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.4853586256504059},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.46964165568351746},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4094688892364502},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3802902400493622},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37238195538520813},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3359884023666382},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28433412313461304},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2525208294391632},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.047177672386169434},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1541-7786.22517619","doi":"https://doi.org/10.1158/1541-7786.22517619","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1541-7786.22517619","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_-Catulin_Marks_the_Invasion_Front_of_Squamous_Cell_Carcinoma_and_Is_Important_for_Tumor_Cell_Metastasis/22517619/1/files/39980214.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1541-7786.22517619","doi":"https://doi.org/10.1158/1541-7786.22517619","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1541-7786.22517619","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_2_from_-Catulin_Marks_the_Invasion_Front_of_Squamous_Cell_Carcinoma_and_Is_Important_for_Tumor_Cell_Metastasis/22517619/1/files/39980214.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4362492494.pdf","grobid_xml":"https://content.openalex.org/works/W4362492494.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4362492535","https://openalex.org/W1978526900","https://openalex.org/W2105820147","https://openalex.org/W1970289555","https://openalex.org/W2146264066","https://openalex.org/W6889296761","https://openalex.org/W2178917500","https://openalex.org/W2277961777","https://openalex.org/W4318067375","https://openalex.org/W2367422897"],"abstract_inverted_index":{"PDF":[0],"file":[1],"-":[2],"44K,":[3],"shRNA":[4],"lentiviral":[5],"system":[6],"was":[7,33,53,82],"used":[8],"to":[9,28],"generate":[10],"stable":[11],"MDA-MB-231":[12,24,57],"cell":[13,47,72],"lines":[14],"that":[15],"were":[16,60],"\ufffd-catulin-deficient.":[17],"The":[18],"specific":[19],"knockdown":[20],"of":[21,92],"\ufffd-catulin":[22],"in":[23,55],"cells":[25,59],"(G85)":[26],"compared":[27],"the":[29],"non-silencing":[30],"control":[31],"(GNS)":[32],"confirmed":[34],"by":[35],"RT-PCR":[36],"(A),":[37],"real-time":[38],"qPCR":[39],"(A'),":[40],"and":[41,50,74],"western":[42],"blot":[43],"(B).":[44],"In":[45],"vitro":[46],"migration":[48,73],"(C)":[49],"invasion":[51,77],"(D)":[52],"decreased":[54],"\ufffd-catulin-ablated":[56],"cells;":[58],"visualized":[61],"with":[62],"toluidine":[63],"blue.":[64],"Standard":[65],"error":[66],"bars":[67],"are":[68],"shown":[69],"(n=4":[70],"for":[71,76],"n=4":[75],"assay).":[78],"***":[79],"statistical":[80],"significance":[81],"determined":[83],"using":[84],"t-test":[85],"(p":[86,95],"<":[87],"0.001)":[88],"or":[89],"*":[90],"analysis":[91],"variant":[93],"(ANOVA)":[94],"<0.02)":[96]},"counts_by_year":[],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2023-04-05T00:00:00"}