{"id":"https://openalex.org/W4362492463","doi":"https://doi.org/10.1158/1541-7786.c.6541792","title":"Data from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance","display_name":"Data from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362492463","doi":"https://doi.org/10.1158/1541-7786.c.6541792"},"language":"en","primary_location":{"id":"doi:10.1158/1541-7786.c.6541792","doi":"https://doi.org/10.1158/1541-7786.c.6541792","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1541-7786.c.6541792","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1541-7786.c.6541792","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yang Zhan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yang Zhan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103045488","display_name":"Guanyi Zhang","orcid":"https://orcid.org/0000-0002-7241-2325","observed_orcids":["https://orcid.org/0000-0002-7241-2325"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guanyi Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100351309","display_name":"Xiaojie Wang","orcid":"https://orcid.org/0000-0003-4817-5830","observed_orcids":["https://orcid.org/0000-0003-4817-5830"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaojie Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100905164","display_name":"Yanfeng Qi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yanfeng Qi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110967604","display_name":"Shanshan Bai","orcid":"https://orcid.org/0000-0003-2439-6444","observed_orcids":["https://orcid.org/0000-0003-2439-6444"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shanshan Bai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101614201","display_name":"Dongying Li","orcid":"https://orcid.org/0000-0003-0721-2500","observed_orcids":["https://orcid.org/0000-0003-0721-2500"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dongying Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054190396","display_name":"Tianfang Ma","orcid":"https://orcid.org/0000-0003-4161-882X","observed_orcids":["https://orcid.org/0000-0003-4161-882X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tianfang Ma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073246821","display_name":"Oliver A. Sartor","orcid":"https://orcid.org/0000-0002-8777-7343","observed_orcids":["https://orcid.org/0000-0002-8777-7343"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oliver Sartor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002551784","display_name":"Erik K. Flemington","orcid":"https://orcid.org/0000-0003-0513-5281","observed_orcids":["https://orcid.org/0000-0003-0513-5281"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erik K. Flemington","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100454598","display_name":"Haitao Zhang","orcid":"https://orcid.org/0000-0002-9616-3079","observed_orcids":["https://orcid.org/0000-0002-9616-3079","https://orcid.org/0000-0002-4091-446X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haitao Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009486201","display_name":"Peng Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peng Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100650284","display_name":"Yan Dong","orcid":"https://orcid.org/0000-0002-5630-2724","observed_orcids":["https://orcid.org/0000-0002-5630-2724","https://orcid.org/0009-0007-8195-6440"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Dong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ar-splice-variants","display_name":"androgen receptor splice variants","score":1.0},{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.9390000104904175},{"id":"https://openalex.org/keywords/ar-v7","display_name":"AR-V7","score":0.8579999804496765},{"id":"https://openalex.org/keywords/full-length-androgen-receptor","display_name":"full-length androgen receptor","score":0.9459999799728394},{"id":"https://openalex.org/keywords/nuclear-cytoplasmic-localization","display_name":"nuclear-cytoplasmic localization","score":0.6620000004768372},{"id":"https://openalex.org/keywords/protein-dimerization","display_name":"protein dimerization","score":0.8130000233650208},{"id":"https://openalex.org/keywords/enzalutamide-resistance","display_name":"enzalutamide resistance","score":0.8989999890327454},{"id":"https://openalex.org/keywords/androgen-receptor-signaling","display_name":"androgen receptor signaling","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.9445837736129761},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.9271578788757324},{"id":"https://openalex.org/C2776551883","wikidata":"https://www.wikidata.org/wiki/Q1996756","display_name":"Enzalutamide","level":5,"score":0.7316216230392456},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7249307632446289},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.6397475004196167},{"id":"https://openalex.org/C49805395","wikidata":"https://www.wikidata.org/wiki/Q910966","display_name":"Nuclear localization sequence","level":3,"score":0.600767195224762},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.49550020694732666},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.492905855178833},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.44199874997138977},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.41953229904174805},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4065520167350769},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3897196054458618},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3895367980003357},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3640725016593933},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33964088559150696},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.1886429786682129},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.17037340998649597},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16196754574775696},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15265464782714844},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1293916404247284},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10846400260925293},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.06789928674697876}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1541-7786.c.6541792","doi":"https://doi.org/10.1158/1541-7786.c.6541792","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1541-7786.c.6541792","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1541-7786.c.6541792","doi":"https://doi.org/10.1158/1541-7786.c.6541792","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1541-7786.c.6541792","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5699999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4361849348","https://openalex.org/W4361849260","https://openalex.org/W2927728931","https://openalex.org/W2069541720","https://openalex.org/W2344231551","https://openalex.org/W2004261902","https://openalex.org/W2954455697","https://openalex.org/W4362492463","https://openalex.org/W4362492483","https://openalex.org/W2525190534"],"abstract_inverted_index":{"Abstract":[0],"Androgen":[1],"receptor":[2],"splice":[3],"variants":[4],"(AR-V)":[5],"are":[6,45],"implicated":[7],"in":[8,19,71,116,187,213,234],"resistance":[9,225],"of":[10,108,121,134,137,147,156,230],"prostate":[11,73],"cancer":[12,74],"to":[13,27,39,60,125,152,160,170,184,227,248],"androgen-directed":[14],"therapies.":[15],"When":[16],"expressed":[17],"alone":[18],"cells,":[20],"some":[21],"AR-Vs":[22,51,67,81,206,233],"(e.g.,":[23,32],"AR-V7)":[24],"localize":[25,37],"primarily":[26],"the":[28,40,43,49,53,65,79,119,122,132,201],"nucleus,":[29],"whereas":[30],"others":[31],"AR-V1,":[33,89,109,177],"AR-V4,":[34],"and":[35,52,82,91,98,102,111,113,139,158,166,169,207,232,237],"AR-V6)":[36],"mainly":[38],"cytoplasm.":[41],"Significantly,":[42],"latter":[44],"often":[46],"coexpressed":[47],"with":[48,78,95],"nucleus-predominant":[50,80],"full-length":[54],"AR":[55,142,164],"(AR-FL).":[56],"An":[57],"important":[58,220],"question":[59],"be":[61],"addressed":[62],"is":[63,86],"whether":[64],"cytoplasmic-localized":[66],"play":[68,209],"a":[69,210],"role":[70,212],"castration-resistant":[72,172,214],"(CRPC)":[75],"through":[76],"interaction":[77],"AR-FL.":[83,99],"Here,":[84],"it":[85,191],"demonstrated":[87],"that":[88,146,200,239],"-V4,":[90,110],"-V6":[92,140,159],"can":[93],"dimerize":[94],"both":[96,162],"AR-V7":[97,101,194],"Consequently,":[100],"androgen-bound":[103],"AR-FL":[104,128,186,208,231],"induced":[105],"nuclear":[106,129,135],"localization":[107,136,150],"-V6,":[112],"these":[114,197,241],"variants,":[115],"turn,":[117],"mitigated":[118],"ability":[120,155],"antiandrogen":[123],"enzalutamide":[124],"inhibit":[126],"androgen-induced":[127],"localization.":[130],"Interestingly,":[131],"impact":[133],"AR-V4":[138,157],"on":[141],"transactivation":[143],"differs":[144],"from":[145],"AR-V1.":[148],"Nuclear":[149],"leads":[151],"an":[153,188],"increased":[154],"transactivate":[161],"canonical":[163],"targets":[165,168],"AR-V\u2013specific":[167],"confer":[171],"cell":[173],"growth.":[174],"However,":[175],"although":[176],"which":[178],"lacks":[179],"inherent":[180],"transcriptional":[181],"activity,":[182],"appears":[183],"activate":[185],"androgen-independent":[189],"manner,":[190],"significantly":[192],"antagonizes":[193],"transactivation.":[195],"Together,":[196],"data":[198],"demonstrate":[199],"complex":[202],"interactions":[203,242],"among":[204],"different":[205],"significant":[211],"disease.":[215],"Implications:":[216],"This":[217],"study":[218],"suggests":[219,238],"consequences":[221],"for":[222],"clinical":[223],"castration":[224],"due":[226],"simultaneous":[228],"expression":[229],"patient":[235],"tumors":[236],"dissecting":[240],"should":[243],"help":[244],"develop":[245],"effective":[246],"strategies":[247],"disrupt":[249],"AR-V":[250],"signaling.":[251],"Mol":[252],"Cancer":[253],"Res;":[254],"15(1);":[255],"59\u201368.":[256],"\u00a92016":[257],"AACR.":[258]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}
