{"id":"https://openalex.org/W4362491981","doi":"https://doi.org/10.1158/1535-7163.22518777.v1","title":"Fig. S2 from Nf1-Mutant Tumors Undergo Transcriptome and Kinome Remodeling after Inhibition of either mTOR or MEK","display_name":"Fig. S2 from Nf1-Mutant Tumors Undergo Transcriptome and Kinome Remodeling after Inhibition of either mTOR or MEK","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362491981","doi":"https://doi.org/10.1158/1535-7163.22518777.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.22518777.v1","doi":"https://doi.org/10.1158/1535-7163.22518777.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22518777.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1535-7163.22518777.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001544400","display_name":"Daniela Pucciarelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniela Pucciarelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067366916","display_name":"Steven P. Angus","orcid":"https://orcid.org/0000-0002-7655-657X","observed_orcids":["https://orcid.org/0000-0002-7655-657X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven P. Angus","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7655-657X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053709403","display_name":"Benjamin J. Huang","orcid":"https://orcid.org/0000-0001-6996-0833","observed_orcids":["https://orcid.org/0000-0001-6996-0833"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benjamin Huang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6996-0833","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012408594","display_name":"Chi Zhang","orcid":"https://orcid.org/0000-0001-9553-0925","observed_orcids":["https://orcid.org/0000-0001-9553-0925"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chi Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9553-0925","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001395999","display_name":"Hiroki J. Nakaoka","orcid":"https://orcid.org/0000-0002-1642-5631","observed_orcids":["https://orcid.org/0000-0002-1642-5631"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroki J. Nakaoka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043295445","display_name":"Ganesh Krishnamurthi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ganesh Krishnamurthi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028835470","display_name":"Sourav Bandyopadhyay","orcid":"https://orcid.org/0000-0003-3120-923X","observed_orcids":["https://orcid.org/0000-0003-3120-923X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sourav Bandyopadhyay","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3120-923X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056688749","display_name":"D. Wade Clapp","orcid":"https://orcid.org/0000-0001-9465-0917","observed_orcids":["https://orcid.org/0000-0001-9465-0917"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Wade Clapp","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023734568","display_name":"Kevin Shannon","orcid":"https://orcid.org/0000-0003-4299-1773","observed_orcids":["https://orcid.org/0000-0003-4299-1773"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin Shannon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047612906","display_name":"Gary L. Johnson","orcid":"https://orcid.org/0000-0003-2867-0551","observed_orcids":["https://orcid.org/0000-0003-2867-0551"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary L. Johnson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2867-0551","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5018329012","display_name":"Jean L. Nakamura","orcid":"https://orcid.org/0000-0002-2097-9223","observed_orcids":["https://orcid.org/0000-0002-2097-9223"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean L. Nakamura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.7836999893188477,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.7836999893188477,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.05959999933838844,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.047600001096725464,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurofibromatosis-type-1","display_name":"neurofibromatosis type 1","score":0.9259999990463257},{"id":"https://openalex.org/keywords/tumor-transcriptome","display_name":"tumor transcriptome","score":0.75},{"id":"https://openalex.org/keywords/mtor-inhibition","display_name":"mTOR inhibition","score":0.9909999966621399},{"id":"https://openalex.org/keywords/mek-inhibition","display_name":"MEK inhibition","score":0.9900000095367432},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C54174078","wikidata":"https://www.wikidata.org/wiki/Q3197188","display_name":"Kinome","level":3,"score":0.9318710565567017},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6847710609436035},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5983734130859375},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5638555288314819},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5485520958900452},{"id":"https://openalex.org/C2781249067","wikidata":"https://www.wikidata.org/wiki/Q17142288","display_name":"MEK inhibitor","level":4,"score":0.5072352886199951},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4241958260536194},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3719026446342468},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3505423069000244},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.34467431902885437},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32932454347610474},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.2454582154750824},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1675252914428711},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.14925771951675415},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14270085096359253},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.10216280817985535}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1535-7163.22518777.v1","doi":"https://doi.org/10.1158/1535-7163.22518777.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22518777.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22518777","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Fig_S2_from_i_Nf1_i_-Mutant_Tumors_Undergo_Transcriptome_and_Kinome_Remodeling_after_Inhibition_of_either_mTOR_or_MEK/22518777","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.22518777.v1","doi":"https://doi.org/10.1158/1535-7163.22518777.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22518777.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4362491780","https://openalex.org/W4362491776","https://openalex.org/W4362491865","https://openalex.org/W4362492141","https://openalex.org/W4362491792","https://openalex.org/W4362491882","https://openalex.org/W4362492044","https://openalex.org/W4362491915","https://openalex.org/W3080424338","https://openalex.org/W4361876344"],"abstract_inverted_index":{"Supplementary":[0],"Figure":[1],"2":[2]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2023-04-05T00:00:00"}
