{"id":"https://openalex.org/W4362491773","doi":"https://doi.org/10.1158/1541-7786.c.6542071","title":"Data from EGFR Signals Downregulate Tumor Suppressors miR-143 and miR-145 in Western Diet\u2013Promoted Murine Colon Cancer: Role of G1 Regulators","display_name":"Data from EGFR Signals Downregulate Tumor Suppressors miR-143 and miR-145 in Western Diet\u2013Promoted Murine Colon Cancer: Role of G1 Regulators","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362491773","doi":"https://doi.org/10.1158/1541-7786.c.6542071"},"language":"en","primary_location":{"id":"doi:10.1158/1541-7786.c.6542071","doi":"https://doi.org/10.1158/1541-7786.c.6542071","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1541-7786.c.6542071","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1541-7786.c.6542071","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100569776","display_name":"Hongyan Zhu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hongyan Zhu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074161692","display_name":"Urszula Dougherty","orcid":"https://orcid.org/0009-0003-9321-6862","observed_orcids":["https://orcid.org/0009-0003-9321-6862"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Urszula Dougherty","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103283683","display_name":"Victoria L. Robinson","orcid":"https://orcid.org/0009-0004-5024-3382","observed_orcids":["https://orcid.org/0009-0004-5024-3382"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Victoria Robinson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035049656","display_name":"Reba Mustafi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reba Mustafi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059142660","display_name":"Joel R. Pekow","orcid":"https://orcid.org/0000-0002-4790-8994","observed_orcids":["https://orcid.org/0000-0002-4790-8994"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joel Pekow","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109534186","display_name":"Sonia S. Kupfer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sonia Kupfer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100639697","display_name":"Yanchun Li","orcid":"https://orcid.org/0000-0003-3781-4166","observed_orcids":["https://orcid.org/0000-0003-3781-4166"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan-Chun Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101841548","display_name":"John A L Hart","orcid":"https://orcid.org/0000-0002-8929-2462","observed_orcids":["https://orcid.org/0000-0002-8929-2462"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Hart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022688838","display_name":"Kathleen H. Goss","orcid":"https://orcid.org/0000-0002-7379-5639","observed_orcids":["https://orcid.org/0000-0002-7379-5639"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kathleen Goss","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016541773","display_name":"Alessandro Fichera","orcid":"https://orcid.org/0000-0003-4205-4413","observed_orcids":["https://orcid.org/0000-0003-4205-4413"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alessandro Fichera","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035169905","display_name":"Loren J. Joseph","orcid":"https://orcid.org/0000-0002-9503-4689","observed_orcids":["https://orcid.org/0000-0002-9503-4689"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Loren Joseph","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5005112247","display_name":"Marc Bissonnette","orcid":"https://orcid.org/0000-0001-8420-4294","observed_orcids":["https://orcid.org/0000-0001-8420-4294"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marc Bissonnette","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/egfr-signaling","display_name":"EGFR signaling","score":0.8600000143051147},{"id":"https://openalex.org/keywords/mir-143","display_name":"miR-143","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mir-145","display_name":"miR-145","score":1.0},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.7260000109672546},{"id":"https://openalex.org/keywords/western-diet","display_name":"Western diet","score":0.9390000104904175},{"id":"https://openalex.org/keywords/tumor-promotion","display_name":"tumor promotion","score":0.5090000033378601},{"id":"https://openalex.org/keywords/colon-carcinogenesis","display_name":"colon carcinogenesis","score":0.8069999814033508},{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.8379999995231628},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cyclin-d2","display_name":"cyclin D2","score":0.9380000233650208},{"id":"https://openalex.org/keywords/cdk6","display_name":"CDK6","score":0.9710000157356262},{"id":"https://openalex.org/keywords/e2f3","display_name":"E2F3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/azoxymethane","display_name":"azoxymethane","score":0.7590000033378601},{"id":"https://openalex.org/keywords/tumor-suppressor-microrna","display_name":"tumor suppressor microRNA","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C2778452354","wikidata":"https://www.wikidata.org/wiki/Q794084","display_name":"Azoxymethane","level":4,"score":0.8599535822868347},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6804152727127075},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6594355702400208},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5976989269256592},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5545361638069153},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5255088806152344},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.4960969388484955},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47050803899765015},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37704217433929443},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3749983310699463},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3626808524131775},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35257983207702637},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30416420102119446},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07266324758529663},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1541-7786.c.6542071","doi":"https://doi.org/10.1158/1541-7786.c.6542071","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1541-7786.c.6542071","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1541-7786.c.6542071.v1","doi":"https://doi.org/10.1158/1541-7786.c.6542071.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.6542071.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1541-7786.c.6542071","doi":"https://doi.org/10.1158/1541-7786.c.6542071","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1541-7786.c.6542071","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2123961393","https://openalex.org/W3142666815","https://openalex.org/W2075818441","https://openalex.org/W1985726110","https://openalex.org/W1985305471","https://openalex.org/W2039906687","https://openalex.org/W1985237658","https://openalex.org/W3116874627","https://openalex.org/W2010602013","https://openalex.org/W2518580496"],"abstract_inverted_index":{"Abstract":[0],"Epidermal":[1],"growth":[2,183],"factor":[3],"receptors":[4],"(EGFR)":[5],"contribute":[6,42],"to":[7,37,43],"colonic":[8,25,45,48,107,143,174,214],"tumorigenesis":[9],"in":[10,74,103,114,117,125,130,139,150,157,170,184,187,213,231],"experimental":[11],"models":[12,233],"of":[13,33,94,203,234,245],"colon":[14,85,162,235],"cancer.":[15,236],"We":[16],"previously":[17],"showed":[18],"that":[19,41],"EGFR":[20,95,164,226],"was":[21,36],"also":[22,155],"required":[23],"for":[24,89],"tumor":[26,242],"promotion":[27],"by":[28,69],"Western":[29,224,238],"diet.":[30,225],"The":[31],"goal":[32],"this":[34],"study":[35],"identify":[38],"EGFR-regulated":[39,247],"microRNAs":[40],"diet-promoted":[44],"tumorigenesis.":[46],"Murine":[47],"tumors":[49,144,215],"from":[50,145,216],"Egfrwt":[51,131,146,217],"and":[52,63,65,73,78,81,91,98,105,109,116,120,128,132,141,160,168,172,178,186,189,197,209,229],"hypomorphic":[53],"Egfrwa2":[54,133,151,220],"mice":[55,147,221],"were":[56,87,101,122,137,154,211],"screened":[57],"using":[58],"micro":[59],"RNA":[60],"(miRNA)":[61],"arrays":[62],"miR-143":[64,90,97,119,167,177,228],"miR-145":[66,99,121,169,179,230],"changes":[67],"confirmed":[68],"Northern,":[70],"real-time":[71],"PCR,":[72],"situ":[75],"analysis.":[76],"Rodent":[77],"human":[79,106,158,171],"sporadic":[80,159],"ulcerative":[82],"colitis":[83],"(UC)-associated":[84],"cancers":[86],"examined":[88,113],"miR-145.":[92],"Effects":[93],"on":[96],"expression":[100],"assessed":[102],"murine":[104,173,232],"cells":[108],"their":[110],"putative":[111,199],"targets":[112,202,207],"vitro":[115,185],"vivo.":[118],"readily":[123],"detected":[124],"normal":[126],"colonocytes":[127],"comparable":[129],"mice.":[134],"These":[135],"miRNAs":[136],"downregulated":[138,190],"azoxymethane":[140],"inflammation-associated":[142],"but":[148,218],"upregulated":[149],"tumors.":[152],"They":[153],"reduced":[156],"UC":[161],"cancers.":[163],"signals":[165],"suppressed":[166],"cells.":[175],"Transfected":[176],"inhibited":[180],"HCT116":[181],"cell":[182],"vivo":[188],"G1":[191],"regulators,":[192],"K-Ras,":[193],"MYC,":[194],"CCND2,":[195],"cdk6,":[196],"E2F3,":[198],"or":[200],"established":[201],"these":[204,246],"miRNAs.":[205,248],"miRNA":[206],"Ras":[208],"MYC":[210],"increased":[212],"not":[219],"fed":[222],"a":[223],"suppresses":[227],"Furthermore,":[237],"diet":[239],"unmasks":[240],"the":[241],"suppressor":[243],"roles":[244],"Mol":[249],"Cancer":[250],"Res;":[251],"9(7);":[252],"960\u201375.":[253],"\u00a92011":[254],"AACR.":[255]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}