{"id":"https://openalex.org/W4362490932","doi":"https://doi.org/10.1158/1535-7163.c.6542677","title":"Data from ERK Inhibition Improves Anti\u2013PD-L1 Immune Checkpoint Blockade in Preclinical Pancreatic Ductal Adenocarcinoma","display_name":"Data from ERK Inhibition Improves Anti\u2013PD-L1 Immune Checkpoint Blockade in Preclinical Pancreatic Ductal Adenocarcinoma","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362490932","doi":"https://doi.org/10.1158/1535-7163.c.6542677"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.c.6542677","doi":"https://doi.org/10.1158/1535-7163.c.6542677","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6542677","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1535-7163.c.6542677","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058237659","display_name":"Kelly E. Henry","orcid":"https://orcid.org/0000-0002-8492-9364","observed_orcids":["https://orcid.org/0000-0002-8492-9364"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly E. Henry","raw_affiliation_strings":["Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":"https://orcid.org/0000-0002-8492-9364","affiliations":[{"raw_affiliation_string":"Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044367027","display_name":"Kyeara N. Mack","orcid":"https://orcid.org/0000-0001-5104-0078","observed_orcids":["https://orcid.org/0000-0001-5104-0078"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyeara N. Mack","raw_affiliation_strings":["Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York","Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":"https://orcid.org/0000-0001-5104-0078","affiliations":[{"raw_affiliation_string":"Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009608524","display_name":"Veronica L. Nagle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Veronica L. Nagle","raw_affiliation_strings":["Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York","Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041336539","display_name":"Mike Cornejo","orcid":"https://orcid.org/0000-0001-6719-5373","observed_orcids":["https://orcid.org/0000-0001-6719-5373"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mike Cornejo","raw_affiliation_strings":["Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076043581","display_name":"Adam O. Michel","orcid":"https://orcid.org/0000-0002-2014-965X","observed_orcids":["https://orcid.org/0000-0002-2014-965X","https://orcid.org/0000-0003-2048-3671"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam O. Michel","raw_affiliation_strings":["Laboratory for Comparative Pathology, Memorial Sloan Kettering, Weill Cornell Medicine & The Rockefeller University, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Comparative Pathology, Memorial Sloan Kettering, Weill Cornell Medicine & The Rockefeller University, New York, New York","institution_ids":["https://openalex.org/I4387153466","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004047303","display_name":"Ian L. Fox","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian L. Fox","raw_affiliation_strings":["Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Maria Davydova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Davydova","raw_affiliation_strings":["Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010700298","display_name":"Thomas R. Dilling","orcid":"https://orcid.org/0000-0001-9714-1122","observed_orcids":["https://orcid.org/0000-0001-9714-1122"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas R. Dilling","raw_affiliation_strings":["Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015570478","display_name":"Nagavarakishore Pillarsetty","orcid":"https://orcid.org/0000-0002-1750-7436","observed_orcids":["https://orcid.org/0000-0002-1750-7436"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nagavarakishore Pillarsetty","raw_affiliation_strings":["Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":"https://orcid.org/0000-0002-1750-7436","affiliations":[{"raw_affiliation_string":"Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068928963","display_name":"Jason Stuart Lewis","orcid":"https://orcid.org/0000-0001-7065-4534","observed_orcids":["https://orcid.org/0000-0001-7065-4534"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason S. Lewis","raw_affiliation_strings":["Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York","Departments of Pharmacology and Radiology, Weill Cornell Medical College, New York, New York","Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York","Radiochemistry and Molecular Imaging Probes Core, Memorial Sloan Kettering Cancer Center, New York, New York"],"raw_orcid":"https://orcid.org/0000-0001-7065-4534","affiliations":[{"raw_affiliation_string":"Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Departments of Pharmacology and Radiology, Weill Cornell Medical College, New York, New York","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Radiochemistry and Molecular Imaging Probes Core, Memorial Sloan Kettering Cancer Center, New York, New York","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.02239999920129776,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.7419999837875366},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.921999990940094},{"id":"https://openalex.org/keywords/erk-inhibition","display_name":"ERK inhibition","score":0.9869999885559082},{"id":"https://openalex.org/keywords/mek-inhibition","display_name":"MEK inhibition","score":0.9950000047683716},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8949999809265137},{"id":"https://openalex.org/keywords/positron-emission-tomography","display_name":"positron emission tomography","score":0.656000018119812},{"id":"https://openalex.org/keywords/zirconium-89","display_name":"zirconium-89","score":0.8840000033378601},{"id":"https://openalex.org/keywords/pd-l1-expression","display_name":"PD-L1 expression","score":0.6919999718666077},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9279999732971191},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.7089999914169312},{"id":"https://openalex.org/keywords/syngeneic-mouse-model","display_name":"syngeneic mouse model","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.8038078546524048},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7122957110404968},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.7040822505950928},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.6396945118904114},{"id":"https://openalex.org/C2781249067","wikidata":"https://www.wikidata.org/wiki/Q17142288","display_name":"MEK inhibitor","level":4,"score":0.5429316759109497},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5218640565872192},{"id":"https://openalex.org/C2781053074","wikidata":"https://www.wikidata.org/wiki/Q21100639","display_name":"PD-L1","level":4,"score":0.5004892349243164},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.48404091596603394},{"id":"https://openalex.org/C2992026798","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic ductal adenocarcinoma","level":4,"score":0.4619683623313904},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.41406887769699097},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.4117487370967865},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.40661367774009705},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.3873295485973358},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3408712148666382},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29596227407455444},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.23731279373168945},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.21070903539657593},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20139479637145996},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17789995670318604},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.09886789321899414}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1535-7163.c.6542677","doi":"https://doi.org/10.1158/1535-7163.c.6542677","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6542677","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1535-7163.c.6542677.v1","doi":"https://doi.org/10.1158/1535-7163.c.6542677.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6542677.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.c.6542677","doi":"https://doi.org/10.1158/1535-7163.c.6542677","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6542677","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1996912024","https://openalex.org/W2002369577","https://openalex.org/W2043991982","https://openalex.org/W2078902726","https://openalex.org/W2130409873","https://openalex.org/W2146616032","https://openalex.org/W2150228337","https://openalex.org/W2151253787","https://openalex.org/W2153091619","https://openalex.org/W2159045665","https://openalex.org/W2165480504","https://openalex.org/W2195541042","https://openalex.org/W2289851792","https://openalex.org/W2435243879","https://openalex.org/W2526479644","https://openalex.org/W2580601893","https://openalex.org/W2605241183","https://openalex.org/W2622499649","https://openalex.org/W2764210227","https://openalex.org/W2772923107","https://openalex.org/W2778152525","https://openalex.org/W2793938850","https://openalex.org/W2796894486","https://openalex.org/W2800046513","https://openalex.org/W2804918531","https://openalex.org/W2807967418","https://openalex.org/W2889415823","https://openalex.org/W2889760268","https://openalex.org/W2897028592","https://openalex.org/W2901272595","https://openalex.org/W2939342954","https://openalex.org/W2941142378","https://openalex.org/W2941560116","https://openalex.org/W2952690424","https://openalex.org/W2988500598","https://openalex.org/W2999889994","https://openalex.org/W2999913708","https://openalex.org/W3029624192","https://openalex.org/W4230457487"],"related_works":["https://openalex.org/W3187166588","https://openalex.org/W4404976015","https://openalex.org/W4401715744","https://openalex.org/W2560628113","https://openalex.org/W2485412821","https://openalex.org/W2487521590","https://openalex.org/W7110517231","https://openalex.org/W2580601893","https://openalex.org/W4385327401","https://openalex.org/W4409626373"],"abstract_inverted_index":{"Abstract":[0],"Patients":[1],"with":[2,46,137],"pancreatic":[3],"ductal":[4],"adenocarcinoma":[5],"(PDAC)":[6],"do":[7],"not":[8],"benefit":[9,158],"from":[10],"immune":[11,122],"checkpoint":[12,123],"blockade":[13],"(ICB)":[14],"along":[15],"the":[16,50,79,102,128,156,182],"PD-1/PD-L1":[17],"axis.":[18],"Variable":[19],"PD-L1":[20,61,88,112],"expression":[21,62,89],"in":[22,63,94,144,185],"PDAC":[23],"indicates":[24,154],"a":[25,41,71,138,145],"potential":[26],"access":[27],"issue":[28],"of":[29,36,78,104,130,141,149],"PD-L1\u2013targeted":[30,37,42],"therapy.":[31,124],"To":[32],"monitor":[33],"target":[34],"engagement":[35],"therapy,":[38],"we":[39,67,99,115],"generated":[40],"PET":[43],"tracer":[44],"labeled":[45],"zirconium-89":[47],"(89Zr).":[48],"As":[49],"MAPK":[51,80],"signaling":[52,81],"pathway":[53],"(MEK":[54],"and":[55,90,133,166,180],"ERK)":[56],"is":[57,108],"known":[58],"to":[59,73,86,110,175],"modulate":[60,87],"other":[64],"tumor":[65],"types,":[66],"used":[68],"[89Zr]Zr-DFO-anti\u2013PD-L1":[69],"as":[70,189],"tool":[72,169],"noninvasively":[74],"assess":[75],"whether":[76],"manipulation":[77],"cascade":[82],"could":[83,117,172],"be":[84,118,160,173],"leveraged":[85,119],"thereby":[91],"immunotherapeutic":[92],"outcomes":[93],"PDAC.":[95,150,190],"In":[96],"this":[97],"study,":[98],"observed":[100],"that":[101,127,155],"inhibition":[103,132],"MEK":[105],"or":[106],"ERK":[107,131],"sufficient":[109],"increase":[111],"expression,":[113],"which":[114],"hypothesized":[116],"for":[120],"anti\u2013PD-L1":[121,134],"We":[125],"found":[126],"combination":[129],"therapy":[135],"corresponded":[136],"significant":[139],"improvement":[140],"overall":[142],"survival":[143,157],"syngeneic":[146],"mouse":[147],"model":[148],"Furthermore,":[151],"IHC":[152],"analysis":[153],"may":[159],"CD8+":[161],"T-cell":[162],"mediated.":[163],"The":[164],"therapeutic":[165,183],"molecular":[167],"imaging":[168],"kit":[170],"developed":[171],"exploited":[174],"better":[176],"structure":[177],"clinical":[178],"trials":[179],"address":[181],"gaps":[184],"challenging":[186],"malignancies":[187],"such":[188]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}
