{"id":"https://openalex.org/W4362490902","doi":"https://doi.org/10.1158/1541-7786.c.6542152.v1","title":"Data from miR-15 and miR-16 Are Direct Transcriptional Targets of E2F1 that Limit E2F-Induced Proliferation by Targeting Cyclin E","display_name":"Data from miR-15 and miR-16 Are Direct Transcriptional Targets of E2F1 that Limit E2F-Induced Proliferation by Targeting Cyclin E","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362490902","doi":"https://doi.org/10.1158/1541-7786.c.6542152.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1541-7786.c.6542152.v1","doi":"https://doi.org/10.1158/1541-7786.c.6542152.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.6542152.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1541-7786.c.6542152.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014309530","display_name":"Matan Ofir","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matan Ofir","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113500404","display_name":"Dalia Hacohen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dalia Hacohen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5042195436","display_name":"Doron Ginsberg","orcid":"https://orcid.org/0000-0002-1257-4920","observed_orcids":["https://orcid.org/0000-0002-1257-4920"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Doron Ginsberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-15a","display_name":"miR-15a","score":0.9070000052452087},{"id":"https://openalex.org/keywords/mir-16-1","display_name":"miR-16-1","score":0.8579999804496765},{"id":"https://openalex.org/keywords/mir-15b","display_name":"miR-15b","score":0.9980000257492065},{"id":"https://openalex.org/keywords/e2f1","display_name":"E2F1","score":0.921999990940094},{"id":"https://openalex.org/keywords/cyclin-e","display_name":"cyclin E","score":0.8889999985694885},{"id":"https://openalex.org/keywords/retinoblastoma-pathway","display_name":"retinoblastoma pathway","score":0.8529999852180481},{"id":"https://openalex.org/keywords/g1-s-transition","display_name":"G1/S transition","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.75},{"id":"https://openalex.org/keywords/feedforward-loop","display_name":"feed-forward loop","score":0.7960000038146973},{"id":"https://openalex.org/keywords/tumor-suppressor-microrna","display_name":"tumor suppressor microRNA","score":0.8730000257492065}],"concepts":[{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.8562728762626648},{"id":"https://openalex.org/C183022183","wikidata":"https://www.wikidata.org/wiki/Q15333016","display_name":"E2F1","level":4,"score":0.8121184706687927},{"id":"https://openalex.org/C83258922","wikidata":"https://www.wikidata.org/wiki/Q24771933","display_name":"E2F","level":4,"score":0.8107879757881165},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7696805000305176},{"id":"https://openalex.org/C2776577112","wikidata":"https://www.wikidata.org/wiki/Q500695","display_name":"Retinoblastoma","level":3,"score":0.5407384037971497},{"id":"https://openalex.org/C11882975","wikidata":"https://www.wikidata.org/wiki/Q24781041","display_name":"Cyclin D","level":5,"score":0.4846809208393097},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.48019254207611084},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46124476194381714},{"id":"https://openalex.org/C16438837","wikidata":"https://www.wikidata.org/wiki/Q5198260","display_name":"Cyclin A","level":5,"score":0.46047109365463257},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4384879171848297},{"id":"https://openalex.org/C94561458","wikidata":"https://www.wikidata.org/wiki/Q24724860","display_name":"Cyclin E","level":5,"score":0.4283861219882965},{"id":"https://openalex.org/C2776062698","wikidata":"https://www.wikidata.org/wiki/Q21111463","display_name":"Retinoblastoma protein","level":4,"score":0.4116678833961487},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.40814244747161865},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40367591381073},{"id":"https://openalex.org/C120089663","wikidata":"https://www.wikidata.org/wiki/Q59250999","display_name":"Cyclin","level":4,"score":0.38180825114250183},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3609139323234558},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22623643279075623},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13034051656723022}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1541-7786.c.6542152.v1","doi":"https://doi.org/10.1158/1541-7786.c.6542152.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.6542152.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1541-7786.c.6542152.v1","doi":"https://doi.org/10.1158/1541-7786.c.6542152.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.6542152.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2119197345","https://openalex.org/W1971917035","https://openalex.org/W1517535303","https://openalex.org/W2074033424","https://openalex.org/W2054551605","https://openalex.org/W2141791387","https://openalex.org/W2170860342","https://openalex.org/W2016578219","https://openalex.org/W2088558156","https://openalex.org/W4392725004"],"abstract_inverted_index":{"Abstract":[0],"microRNAs":[1],"(miR)":[2],"are":[3,19,116],"small":[4],"noncoding":[5],"RNA":[6],"molecules":[7],"that":[8,42,61,97,143,167,177],"have":[9],"recently":[10],"emerged":[11],"as":[12,36,110,112,230],"critical":[13,72],"regulators":[14],"of":[15,75,100,120,125,130,147,157,186,190,199,205,211,234],"gene":[16],"expression":[17,98,129,146,189,201],"and":[18,47,66,107,133,170,181,214,227],"often":[20,85],"deregulated":[21,92],"in":[22,87,91,237],"cancer.":[23],"In":[24,184,220],"particular,":[25],"miRs":[26,53,132],"encoded":[27],"by":[28,55],"the":[29,43,76,101,150,161,165,193,225],"miR-15a,":[30,44,105],"miR-16-1":[31,45,106],"cluster":[32,46,51],"seem":[33],"to":[34],"act":[35],"tumor":[37,77],"suppressors.":[38],"Here,":[39],"we":[40,141],"evidence":[41],"related":[48],"miR-15b,":[49,108],"miR-16-2":[50],"comprise":[52],"regulated":[54],"E2F1,":[56,168],"a":[57,71,152,174],"pivotal":[58,159],"transcription":[59],"factor":[60],"can":[62],"induce":[63],"both":[64,212],"proliferation":[65],"cell":[67],"death.":[68],"E2F1":[69,135],"is":[70,84],"downstream":[73],"target":[74,156],"suppressor":[78],"retinoblastoma":[79],"(RB).":[80],"The":[81],"RB":[82],"pathway":[83],"inactivated":[86],"human":[88],"tumors":[89],"resulting":[90],"E2F":[93,158,179,240],"activity.":[94,241],"We":[95],"show":[96],"levels":[99],"4":[102],"mature":[103],"miRs,":[104],"miR-16-2,":[109],"well":[111],"their":[113,137],"precursor":[114],"pri-miRNAs,":[115],"elevated":[117],"upon":[118],"activation":[119,124],"ectopic":[121,188],"E2F1.":[122],"Moreover,":[123],"endogenous":[126,134],"E2Fs":[127],"upregulates":[128],"these":[131],"binds":[136],"respective":[138],"promoters.":[139],"Importantly,":[140],"corroborate":[142],"miR-15a/b":[144],"inhibits":[145,192],"cyclin":[148,171,206],"E,":[149],"latter":[151],"key":[153],"direct":[154],"transcriptional":[155,232],"for":[160],"G1/S":[162,194,218],"transition,":[163,195],"raising":[164],"possibility":[166],"miR-15,":[169],"E":[172],"constitute":[173],"feed-forward":[175],"loop":[176],"modulates":[178,239],"activity":[180],"cell-cycle":[182],"progression.":[183],"support":[185],"this,":[187],"miR-15":[191,200,213,226],"and,":[196],"conversely,":[197],"inhibition":[198,210],"enhances":[202,216],"E2F1-induced":[203,217],"upregulation":[204],"E1":[207],"levels.":[208],"Furthermore,":[209],"miR-16":[215,228],"transition.":[219],"summary,":[221],"our":[222],"data":[223],"identify":[224],"families":[229],"novel":[231],"targets":[233],"E2F,":[235],"which,":[236],"turn,":[238],"Mol":[242],"Cancer":[243],"Res;":[244],"9(4);":[245],"440\u20137.":[246],"\u00a92011":[247],"AACR.":[248]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-04-05T00:00:00"}