{"id":"https://openalex.org/W4362490859","doi":"https://doi.org/10.1158/1535-7163.c.6542136","title":"Data from Preclinical Development of MGC018, a Duocarmycin-based Antibody\u2013drug Conjugate Targeting B7-H3 for Solid Cancer","display_name":"Data from Preclinical Development of MGC018, a Duocarmycin-based Antibody\u2013drug Conjugate Targeting B7-H3 for Solid Cancer","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362490859","doi":"https://doi.org/10.1158/1535-7163.c.6542136"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.c.6542136","doi":"https://doi.org/10.1158/1535-7163.c.6542136","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6542136","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1535-7163.c.6542136","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088106933","display_name":"Juniper A. Scribner","orcid":"https://orcid.org/0000-0002-4045-9540","observed_orcids":["https://orcid.org/0000-0002-4045-9540"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juniper A. Scribner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003086828","display_name":"Jennifer G. Brown","orcid":"https://orcid.org/0000-0001-7149-1546","observed_orcids":["https://orcid.org/0000-0001-7149-1546"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer G. Brown","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082960633","display_name":"Thomas Son","orcid":"https://orcid.org/0000-0001-7967-5980","observed_orcids":["https://orcid.org/0000-0001-7967-5980"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Son","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018423973","display_name":"Michael Chiechi","orcid":"https://orcid.org/0000-0003-2558-800X","observed_orcids":["https://orcid.org/0000-0003-2558-800X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Chiechi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085855675","display_name":"Pam Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pam Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101795710","display_name":"Sharad Sharma","orcid":"https://orcid.org/0000-0001-7743-3910","observed_orcids":["https://orcid.org/0000-0001-7743-3910"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sharad Sharma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100344257","display_name":"Hua Li","orcid":"https://orcid.org/0000-0003-1903-836X","observed_orcids":["https://orcid.org/0000-0003-1903-836X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hua Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028719199","display_name":"Anushka De Costa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anushka De Costa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100414028","display_name":"Ying Li","orcid":"https://orcid.org/0000-0001-6664-0084","observed_orcids":["https://orcid.org/0000-0001-6664-0084"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ying Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100378024","display_name":"Yan Chen","orcid":"https://orcid.org/0000-0001-6258-082X","observed_orcids":["https://orcid.org/0000-0001-6258-082X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017159713","display_name":"Ann N. Easton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ann Easton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076399955","display_name":"Nicholas C. Yee-Toy","orcid":"https://orcid.org/0000-0003-1916-6687","observed_orcids":["https://orcid.org/0000-0003-1916-6687"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicholas C. Yee-Toy","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1916-6687","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048842300","display_name":"Francine Z. Chen","orcid":"https://orcid.org/0000-0003-4024-9620","observed_orcids":["https://orcid.org/0000-0003-4024-9620"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francine Z. Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056696051","display_name":"Sergey N. Gorlatov","orcid":"https://orcid.org/0000-0002-1430-8765","observed_orcids":["https://orcid.org/0000-0002-1430-8765"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sergey Gorlatov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049112022","display_name":"Bhaswati Barat","orcid":"https://orcid.org/0000-0003-2725-3684","observed_orcids":["https://orcid.org/0000-0003-2725-3684"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bhaswati Barat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Ling Huang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ling Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041656971","display_name":"Christina R. Wolff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christina R. Wolff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089478475","display_name":"Jeff Hooley","orcid":"https://orcid.org/0000-0003-2754-457X","observed_orcids":["https://orcid.org/0000-0003-2754-457X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeff Hooley","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2754-457X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085084835","display_name":"Tim E. Hotaling","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tim E. Hotaling","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112905343","display_name":"Timur R. Gaynutdinov","orcid":"https://orcid.org/0000-0003-3832-883X","observed_orcids":["https://orcid.org/0000-0003-3832-883X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timur Gaynutdinov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061388073","display_name":"Valentina C. Ciccarone","orcid":"https://orcid.org/0000-0001-5530-7112","observed_orcids":["https://orcid.org/0000-0001-5530-7112"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Valentina Ciccarone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016101772","display_name":"James K. Tamura","orcid":"https://orcid.org/0000-0002-0463-2932","observed_orcids":["https://orcid.org/0000-0002-0463-2932"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Tamura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077925652","display_name":"Scott Koenig","orcid":"https://orcid.org/0000-0001-8181-4230","observed_orcids":["https://orcid.org/0000-0001-8181-4230"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott Koenig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023294934","display_name":"Paul A. Moore","orcid":"https://orcid.org/0000-0001-6057-7539","observed_orcids":["https://orcid.org/0000-0001-6057-7539"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul A. Moore","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009027578","display_name":"Ezio Bonvini","orcid":"https://orcid.org/0000-0001-9054-3137","observed_orcids":["https://orcid.org/0000-0001-9054-3137"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ezio Bonvini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5067757338","display_name":"Deryk T. Loo","orcid":"https://orcid.org/0000-0001-6922-0528","observed_orcids":["https://orcid.org/0000-0001-6922-0528"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Deryk Loo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8701000213623047,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8701000213623047,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.03200000151991844,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.029200000688433647,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/duocarmycin","display_name":"duocarmycin","score":0.9190000295639038},{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.9800000190734863},{"id":"https://openalex.org/keywords/b7-h3","display_name":"B7-H3","score":0.996999979019165},{"id":"https://openalex.org/keywords/bystander-killing","display_name":"bystander killing","score":0.652999997138977},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.8479999899864197},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.847000002861023},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8799999952316284},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9319999814033508},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.921999990940094},{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.7680000066757202},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.6470000147819519},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9269999861717224},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7900000214576721},{"id":"https://openalex.org/keywords/cynomolgus-monkeys","display_name":"Macaca fascicularis","score":0.8009999990463257},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5843008160591125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5823885202407837},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5401759147644043},{"id":"https://openalex.org/C2777325958","wikidata":"https://www.wikidata.org/wiki/Q1069596","display_name":"Antibody-drug conjugate","level":4,"score":0.5294404029846191},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5148895978927612},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.5094333291053772},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5041738748550415},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.4708537459373474},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.46740299463272095},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4648439288139343},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.3610677123069763},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.2981931269168854},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2933949828147888},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2488207221031189}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.c.6542136","doi":"https://doi.org/10.1158/1535-7163.c.6542136","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6542136","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.c.6542136","doi":"https://doi.org/10.1158/1535-7163.c.6542136","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6542136","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3087961054","https://openalex.org/W2739700617","https://openalex.org/W4243376020","https://openalex.org/W4362491390","https://openalex.org/W4362491644","https://openalex.org/W4362490726","https://openalex.org/W4362491673","https://openalex.org/W4362491694","https://openalex.org/W3083441441","https://openalex.org/W4285617512"],"abstract_inverted_index":{"Abstract":[0],"B7-H3,":[1],"also":[2],"referred":[3],"to":[4,91],"as":[5,147,149],"CD276,":[6],"is":[7,19,50,78],"a":[8,177,205],"member":[9],"of":[10,14,35,48,56,69,80,106,122,141,161,172,204,215,220],"the":[11,36,66,81,198,212,218],"B7":[12],"family":[13],"immune":[15],"regulatory":[16],"proteins.":[17],"B7-H3":[18,49],"overexpressed":[20],"on":[21],"many":[22],"solid":[23,221],"cancers,":[24],"including":[25],"prostate":[26],"cancer,":[27,43,146],"renal":[28],"cell":[29,33,41,116],"carcinoma,":[30],"melanoma,":[31],"squamous":[32],"carcinoma":[34],"head":[37,165],"and":[38,44,58,118,144,164,166,180,210],"neck,":[39],"non\u2013small":[40],"lung":[42,145],"breast":[45],"cancer.":[46],"Overexpression":[47],"associated":[51],"with":[52,101,128,194,197],"disease":[53],"severity,":[54],"risk":[55],"recurrence":[57],"reduced":[59,98],"survival.":[60],"In":[61,151],"this":[62],"article,":[63],"we":[64],"report":[65],"preclinical":[67,138],"development":[68,214],"MGC018,":[70,195],"an":[71,92,102],"antibody\u2013drug":[72],"conjugate":[73],"targeted":[74],"against":[75],"B7-H3.":[76,173],"MGC018":[77,109,132,175,216],"comprised":[79],"cleavable":[82],"linker-duocarmycin":[83],"payload,":[84],"valine-citrulline-seco":[85],"duocarmycin":[86],"hydroxybenzamide":[87],"azaindole":[88],"(vc-seco-DUBA),":[89],"conjugated":[90],"anti-B7-H3":[93],"humanized":[94],"IgG1/kappa":[95],"mAb":[96],"through":[97],"interchain":[99],"disulfides,":[100],"average":[103],"drug-to-antibody":[104],"ratio":[105],"approximately":[107],"2.7.":[108],"exhibited":[110,119,176],"cytotoxicity":[111],"toward":[112,157],"B7-H3\u2013positive":[113,129],"human":[114],"tumor":[115,124,130,139],"lines,":[117],"bystander":[120],"killing":[121],"target-negative":[123],"cells":[125],"when":[126],"cocultured":[127],"cells.":[131],"displayed":[133],"potent":[134],"antitumor":[135,153,190],"activity":[136,154,191],"in":[137,183],"models":[140,160],"breast,":[142,162],"ovarian,":[143],"well":[148],"melanoma.":[150],"addition,":[152],"was":[155],"observed":[156,192],"patient-derived":[158],"xenograft":[159],"prostate,":[163],"neck":[167],"cancer":[168],"displaying":[169],"heterogeneous":[170],"expression":[171],"Importantly,":[174],"favorable":[178,207],"pharmacokinetic":[179],"safety":[181,200],"profile":[182],"cynomolgus":[184],"monkeys":[185],"following":[186],"repeat-dose":[187],"administration.":[188],"The":[189],"preclinically":[193],"together":[196],"positive":[199],"profile,":[201],"provides":[202],"evidence":[203],"potentially":[206],"therapeutic":[208],"index":[209],"supports":[211],"continued":[213],"for":[217],"treatment":[219],"cancers.":[222]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2023-04-05T00:00:00"}