{"id":"https://openalex.org/W4362489757","doi":"https://doi.org/10.1158/1535-7163.22521016","title":"Supplementary Data Figure S2 from ARX788, a Site-specific Anti-HER2 Antibody\u2013Drug Conjugate, Demonstrates Potent and Selective Activity in HER2-low and T-DM1\u2013resistant Breast and Gastric Cancers","display_name":"Supplementary Data Figure S2 from ARX788, a Site-specific Anti-HER2 Antibody\u2013Drug Conjugate, Demonstrates Potent and Selective Activity in HER2-low and T-DM1\u2013resistant Breast and Gastric Cancers","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362489757","doi":"https://doi.org/10.1158/1535-7163.22521016"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.22521016","doi":"https://doi.org/10.1158/1535-7163.22521016","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22521016","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1535-7163.22521016","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034466570","display_name":"Lillian K. Skidmore","orcid":"https://orcid.org/0009-0005-8277-8223","observed_orcids":["https://orcid.org/0009-0005-8277-8223"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lillian Skidmore","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033541676","display_name":"Sukumar Sakamuri","orcid":"https://orcid.org/0000-0002-0068-8621","observed_orcids":["https://orcid.org/0000-0002-0068-8621"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sukumar Sakamuri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031305401","display_name":"Nick A. Knudsen","orcid":"https://orcid.org/0009-0004-7026-0366","observed_orcids":["https://orcid.org/0009-0004-7026-0366"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nick A. Knudsen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054642615","display_name":"Amha Gebre Hewet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amha Gebre Hewet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061158544","display_name":"Snezana Milutinovic","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Snezana Milutinovic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042034836","display_name":"Wisam Barkho","orcid":"https://orcid.org/0009-0004-2247-0684","observed_orcids":["https://orcid.org/0009-0004-2247-0684"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wisam Barkho","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072628042","display_name":"Sandra Lyn Biroc","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandra Lyn Biroc","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074101492","display_name":"Jessica Kirtley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessica Kirtley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057990743","display_name":"Robin Marsden","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robin Marsden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077168600","display_name":"Kristine Storey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kristine Storey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043135074","display_name":"Ianina Lopez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ianina Lopez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005630266","display_name":"Wayne Yu","orcid":"https://orcid.org/0000-0003-2218-1490","observed_orcids":["https://orcid.org/0000-0003-2218-1490"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wayne Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068566594","display_name":"Shiao-Yan Fang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shiao-Yan Fang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102133544","display_name":"Sulan Yao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sulan Yao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002687748","display_name":"Yi Gu","orcid":"https://orcid.org/0000-0002-8917-9857","observed_orcids":["https://orcid.org/0000-0002-8917-9857"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yi Gu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100745509","display_name":"Feng Tian","orcid":"https://orcid.org/0000-0003-3568-1865","observed_orcids":["https://orcid.org/0000-0003-3568-1865"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Feng Tian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.8939999938011169},{"id":"https://openalex.org/keywords/her2-low-breast-cancer","display_name":"HER2-low breast cancer","score":0.8799999952316284},{"id":"https://openalex.org/keywords/mda-mb-435-cells","display_name":"MDA-MB-435 cells","score":0.9900000095367432},{"id":"https://openalex.org/keywords/her2-expression","display_name":"HER2 expression","score":0.6700000166893005},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.843999981880188},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C182516595","wikidata":"https://www.wikidata.org/wiki/Q376660","display_name":"Nat","level":2,"score":0.6086167693138123},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.5173220634460449},{"id":"https://openalex.org/C2777325958","wikidata":"https://www.wikidata.org/wiki/Q1069596","display_name":"Antibody-drug conjugate","level":4,"score":0.4993271827697754},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.46367383003234863},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41438543796539307},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4004024565219879},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3627644181251526},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3483405113220215},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33174651861190796},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22507330775260925},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.18368342518806458},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/1535-7163.22521016","doi":"https://doi.org/10.1158/1535-7163.22521016","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22521016","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1535-7163.22521016.v1","doi":"https://doi.org/10.1158/1535-7163.22521016.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22521016.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Data_Figure_S2_from_ARX788_a_Site-specific_Anti-HER2_Antibody_Drug_Conjugate_Demonstrates_Potent_and_Selective_Activity_in_HER2-low_and_T-DM1_resistant_Breast_and_Gastric_Cancers/22521016/1/files/39983665.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22521016","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Data_Figure_S2_from_ARX788_a_Site-specific_Anti-HER2_Antibody_Drug_Conjugate_Demonstrates_Potent_and_Selective_Activity_in_HER2-low_and_T-DM1_resistant_Breast_and_Gastric_Cancers/22521016","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.22521016","doi":"https://doi.org/10.1158/1535-7163.22521016","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.22521016","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4362489757.pdf","grobid_xml":"https://content.openalex.org/works/W4362489757.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3042830787","https://openalex.org/W4362489844","https://openalex.org/W2997835015","https://openalex.org/W4221003995","https://openalex.org/W4295837140","https://openalex.org/W4220906504","https://openalex.org/W4396590929","https://openalex.org/W7129598485","https://openalex.org/W4281966254","https://openalex.org/W4361954350"],"abstract_inverted_index":{"ARX788":[0,39],"activity":[1],"in":[2],"HER2-transduced":[3],"MDA-MB-435":[4,6,31],"pools.":[5],"cells":[7,32],"transduced":[8],"with":[9,15,38],"HER2":[10,20,25],"were":[11,36],"sorted":[12],"into":[13],"pools":[14,35],"low,":[16],"medium,":[17],"and":[18,22,33,46],"high":[19],"expression":[21,26],"quantified":[23],"for":[24,40],"by":[27],"QiFiKit":[28],"analysis.":[29],"Parental":[30],"the":[34],"treated":[37],"3":[41],"days":[42],"at":[43],"37{degree":[44],"sign}C,":[45],"cell":[47],"viability":[48],"was":[49],"measured.":[50]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}
