{"id":"https://openalex.org/W4362487891","doi":"https://doi.org/10.1158/1535-7163.22522995","title":"Supplementary Figure from CD74-NRG1 Fusions Are Oncogenic In Vivo and Induce Therapeutically Tractable ERBB2:ERBB3 Heterodimerization","display_name":"Supplementary Figure from CD74-NRG1 Fusions Are Oncogenic In Vivo and Induce Therapeutically Tractable ERBB2:ERBB3 Heterodimerization","publication_year":2023,"publication_date":"2023-04-03","ids":{"openalex":"https://openalex.org/W4362487891","doi":"https://doi.org/10.1158/1535-7163.22522995"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.22522995","doi":"https://doi.org/10.1158/1535-7163.22522995","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22522995","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1535-7163.22522995","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044635759","display_name":"Lisa Werr","orcid":"https://orcid.org/0000-0002-3697-4136","observed_orcids":["https://orcid.org/0000-0002-3697-4136"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisa Werr","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3697-4136","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067754981","display_name":"Dennis Plenker","orcid":"https://orcid.org/0000-0003-3895-4064","observed_orcids":["https://orcid.org/0000-0003-3895-4064"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dennis Plenker","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3895-4064","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056501180","display_name":"Marcel\u00a0Andre Dammert","orcid":"https://orcid.org/0000-0003-4269-7822","observed_orcids":["https://orcid.org/0000-0003-4269-7822"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcel A. Dammert","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4269-7822","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015051535","display_name":"Carina Lorenz","orcid":"https://orcid.org/0009-0006-7827-8055","observed_orcids":["https://orcid.org/0009-0006-7827-8055"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carina Lorenz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086985238","display_name":"Johannes Br\u00e4gelmann","orcid":"https://orcid.org/0000-0002-1306-2169","observed_orcids":["https://orcid.org/0000-0002-1306-2169"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johannes Br\u00e4gelmann","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1306-2169","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036838488","display_name":"Hannah Lea Tumbrink","orcid":"https://orcid.org/0009-0007-8256-7498","observed_orcids":["https://orcid.org/0009-0007-8256-7498"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hannah L. Tumbrink","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067129030","display_name":"Sebastian Klein","orcid":"https://orcid.org/0000-0002-2188-9377","observed_orcids":["https://orcid.org/0000-0002-2188-9377"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sebastian Klein","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2188-9377","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078156775","display_name":"Anna Schmitt","orcid":"https://orcid.org/0009-0002-7655-1805","observed_orcids":["https://orcid.org/0009-0002-7655-1805"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Schmitt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006712577","display_name":"Reinhard B\u00fcttner","orcid":"https://orcid.org/0000-0001-8806-4786","observed_orcids":["https://orcid.org/0000-0001-8806-4786"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reinhard B\u00fcttner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014839908","display_name":"Thors\ufefften Persigehl","orcid":"https://orcid.org/0000-0001-5928-4405","observed_orcids":["https://orcid.org/0000-0001-5928-4405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thorsten Persigehl","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5928-4405","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079376363","display_name":"Kevan M. Shokat","orcid":"https://orcid.org/0000-0001-8590-7741","observed_orcids":["https://orcid.org/0000-0001-8590-7741"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevan M. Shokat","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8590-7741","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072937215","display_name":"Frank Thomas Wunderlich","orcid":"https://orcid.org/0000-0002-9209-3501","observed_orcids":["https://orcid.org/0000-0002-9209-3501"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Thomas Wunderlich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088495181","display_name":"Alison M. Schram","orcid":"https://orcid.org/0000-0002-6070-2413","observed_orcids":["https://orcid.org/0000-0002-6070-2413"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alison M. Schram","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6070-2413","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068488866","display_name":"Martin Peifer","orcid":"https://orcid.org/0000-0002-5243-5503","observed_orcids":["https://orcid.org/0000-0002-5243-5503"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin Peifer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055111767","display_name":"Martin L. Sos","orcid":"https://orcid.org/0000-0002-2868-100X","observed_orcids":["https://orcid.org/0000-0002-2868-100X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin L. Sos","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2868-100X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030035319","display_name":"Hans Christian Reinhardt","orcid":"https://orcid.org/0000-0001-5706-9349","observed_orcids":["https://orcid.org/0000-0001-5706-9349"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Christian Reinhardt","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5706-9349","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5058511375","display_name":"Roman Kurt Thomas","orcid":"https://orcid.org/0000-0001-9132-4876","observed_orcids":["https://orcid.org/0000-0001-9132-4876"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roman K. Thomas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuregulin-1","display_name":"neuregulin-1","score":0.703000009059906},{"id":"https://openalex.org/keywords/erbb2","display_name":"ERBB2","score":0.796999990940094},{"id":"https://openalex.org/keywords/her3","display_name":"HER3","score":0.9909999966621399},{"id":"https://openalex.org/keywords/receptor-heterodimerization","display_name":"receptor heterodimerization","score":0.7620000243186951},{"id":"https://openalex.org/keywords/oncogenicity","display_name":"oncogenicity","score":0.8389999866485596},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.4269999861717224}],"concepts":[{"id":"https://openalex.org/C115456853","wikidata":"https://www.wikidata.org/wiki/Q17917132","display_name":"ERBB3","level":4,"score":0.7469021677970886},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6523000001907349},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4660450220108032},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43790027499198914},{"id":"https://openalex.org/C119997001","wikidata":"https://www.wikidata.org/wiki/Q21113110","display_name":"CD74","level":5,"score":0.4255378544330597},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37202876806259155},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35946518182754517},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.330577552318573},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22749599814414978},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16789093613624573},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.16349589824676514},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.0956522524356842},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.07442677021026611},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.22522995","doi":"https://doi.org/10.1158/1535-7163.22522995","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22522995","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.22522995","doi":"https://doi.org/10.1158/1535-7163.22522995","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22522995","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4220704529","https://openalex.org/W4362487839","https://openalex.org/W7139472712","https://openalex.org/W2951773142","https://openalex.org/W4282963395","https://openalex.org/W7040199069","https://openalex.org/W2806194188","https://openalex.org/W3107627565","https://openalex.org/W4379283384","https://openalex.org/W3031850375"],"abstract_inverted_index":{"Supplementary":[0],"Figure":[1],"from":[2],"CD74-NRG1":[3],"Fusions":[4],"Are":[5],"Oncogenic":[6],"In":[7],"Vivo":[8],"and":[9],"Induce":[10],"Therapeutically":[11],"Tractable":[12],"ERBB2:ERBB3":[13],"Heterodimerization":[14]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-04-05T00:00:00"}